<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12886

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSSLVSRTAEESFTSLKELVEKSKSSDQSDTEKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAVEVLLTGSYERLPKCIEDVGMQSSLTEDQQKPALKKLDTLVRSKLLEVSLPKEISEVKVADGTALIRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERSGLVKLEQMRRHVLGDDLERRMSTAENPFATLYSVLHELCVALVMDTVIRQVQALRLGRWKDAIRFELISDGGSGGSSQLNQDNDSDSAAQRTPGLKLVYWLDFDKNSGASDTGSCPYIKIEPGPDLQIKCQHSTFVIDPLTGKEASFFLDQSCIDVEKLLLRAISCNRYTRLLEIQKELMKNVHIFRDANDVVLLSQSDEPDSEHRKEDAKLDNKEHEGQELLRVRAYGSSYFTLGINIRNGRFLLQSSQNILSSSALLEGEETLNQGTMTAVDVFSSLRSKSIIHLFAAIGRFLGLEVYEHGFAAVKVPKNLVNGSSVLIMGFPESESSYFLLMELDKDFKPLFKLLETQPDPSGKGHSFNDLNNVLRIKKIDINQMQMLEDETNLSILDWRKLLPSLPNVGGPDQISEHDVLNLDGSMQVPGGPSSSFSSIVDEVFEIEKGTSATQFPSQKISSFSSSPASHLTSVPMNLHSVKAGTPSPKWEAGLQVSQHNNVAKPSGRSTSAKKLSASKSEQDLASLRSPHSVDNGVLDEDQLRLPNDTSKDTLSASRSSRLLSPPRPTLPRVIAQNAKPNGPRSSSAGNLTAAVRFSGSSPLASPPVSQAAETKIFHGPSHDASKHDQNPRKCKISNLLSLIPSLQYIEADAGFSKRRKTSDVACTQQPTSQVLKSSEIISKSETYSYGNLIAEANKGNVPSGIYVSALLHVVRHSSLCIKHAKLTSQMEELDIPYVEEVGLRNASSNIWFRLPCSQGDSWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSTSTPWGSGIRIANTSHVDSHIRYDPDGVVLSYQSVEADSIKKLVADIRRLSNARTFALGMWKLLGVRADDKPEEGNANSDVKAPAGGKGPTEAVDKLSEHMRRSFRIEAVGLLSLWFCFGSGVLARFVVEWESDKEGCTMHVSPDQLWPHTKFLEDFIDGAEVASLLDCIRLTAGPLHALAAATRPARASPAPGVSGPSGVISSVPKQPGYSPLQGLLPSSSTTNVNQAAAAVPAGNTASASASSIGNHSIHGAAMLAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPSTPPRGGSYVGGSLPCPQFRPFIMEHVAQELNGLDSSFTSGQQTVGPANSNNPNLSSGPQLSANGSRVNLPTSAAMSRAANQVAGLNRVGNSLPGSPNLAVVSSGLPIRRPPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPVVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNNANSQEELTQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLALTQSGDIAPAQKPRIELCLENHTGVNVGDASESSSATKSNIYYDRPHNSVDFALTVVLDPALIPHINTAGGAAWLPYCVSVRLRYSFGENPNVSFLGMEGSHGGRACWLRLDEWEKCKQRVARTVEVSGSSPADATQGRLRIVADNVQRAXHLCLQGLSNGVSKLDKNPTNSFFIISSFKSKLSLLI
Length1806
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.06
Grand average of hydropathy-0.235
Instability index45.50
Isoelectric point7.58
Molecular weight196958.35
Publications
PubMed=25893780

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP12886
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.22|      34|      36|     727|     762|       1
---------------------------------------------------------------------------
  744-  780 (51.41/32.20)	SVDNGVLDEDQLRLPNDTSkdtLSASRSSRLLSPPR.P
  781-  818 (44.80/26.74)	TLPRVIAQNAKPNGPRSSSagnLTAAVRFSGSSPLAsP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.10|      15|     917|     829|     843|       2
---------------------------------------------------------------------------
  829-  843 (31.12/19.43)	FHGPSHDASKHDQNP
 1774- 1788 (26.98/15.75)	LQGLSNGVSKLDKNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.27|      18|     917|     702|     720|       3
---------------------------------------------------------------------------
  702-  720 (29.17/26.81)	WEAGLQVSQHNNVAkPSGR
 1614- 1631 (32.09/23.67)	WKKGLALTQSGDIA.PAQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     228.34|      72|     917|     434|     587|       4
---------------------------------------------------------------------------
  441-  512 (120.16/167.89)	LRVRAYGSSYFTLGINIRNGRFL..LQ..SSQNILSSSALLEGEETLNQGTMTAVD..VFS..SLRSKSIIHLFAAIGRF
  979- 1058 (108.18/35.33)	LRLGRPGSMYWDVKINDQHFRDLweLQkgSTSTPWGSGIRIANTSHVDSHIRYDPDgvVLSyqSVEADSIKKLVADIRRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.54|      34|     917|     200|     235|       5
---------------------------------------------------------------------------
  200-  235 (55.85/53.69)	GHLSLWRIL...HLELLVGERSGlvKLEQMRRHVLGDDL
 1119- 1155 (59.69/49.72)	GLLSLWFCFgsgVLARFVVEWES..DKEGCTMHVSPDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.85|      19|      20|    1375|    1393|       6
---------------------------------------------------------------------------
 1375- 1393 (33.48/20.03)	PNLSSGPQLSANGSRV..NLP
 1396- 1416 (26.38/14.06)	AAMSRAANQVAGLNRVgnSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.82|      27|     710|     615|     650|       7
---------------------------------------------------------------------------
  615-  650 (46.22/42.15)	PSLPNVGGPdqisehdvlNLDGSMQVP..............GGPSSSFSS
 1322- 1362 (45.60/24.51)	PSTPPRGGS.........YVGGSLPCPqfrpfimehvaqelNGLDSSFTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.55|      17|      19|    1198|    1215|       8
---------------------------------------------------------------------------
 1198- 1215 (25.98/18.89)	SPAPGVSgPSGVISSVPK
 1220- 1236 (29.58/16.31)	SPLQGLL.PSSSTTNVNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.85|      48|     575|     349|     403|      10
---------------------------------------------------------------------------
  349-  403 (72.03/62.02)	QHSTFVIdpltgKEASFFLDQSCID...VEKLLLRAISCNRYTRLLEIQKELMKnvHI
  927-  977 (82.82/52.24)	RHSSLCI.....KHAKLTSQMEELDipyVEEVGLRNASSNIWFRLPCSQGDSWQ..HI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.96|      15|      24|    1463|    1486|      11
---------------------------------------------------------------------------
 1463- 1478 (22.10/28.99)	WVPVVaLKKVLRGILK
 1488- 1502 (24.86/ 6.98)	QLPEL.LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.65|      11|    1355|     143|     153|      15
---------------------------------------------------------------------------
  143-  153 (19.68/13.41)	LTEDQQKPALK
 1509- 1519 (19.97/13.74)	LNLDQEQPALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.70|      22|    1355|      98|     119|      16
---------------------------------------------------------------------------
   98-  119 (40.16/23.36)	LFFMHEGLQQARAPVYDVPSAV
 1421- 1442 (39.54/22.89)	LAVVSSGLPIRRPPGSGVPAHV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12886 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLDSSFTSGQQTVGPANSNNPNLSSGPQLSAN
2) LTSVPMNLHSVKAGTPSPKWEAGLQVSQHNNVAKPSGRSTSAKKLSASKSEQDLASLRSPHSVDNGVLDEDQLRLPNDTSKDTLSASRSSRLLSPPRPTLPRVIAQNAKPNGPRSSSAGNLTAAVRFSGSSPLASPPVSQAAETKIFHGPSHDASKHDQNP
1355
683
1386
843










Molecular Recognition Features






MoRF SequenceStartStop




1) LKRISLKMLTMENRSQSTVPKTRNKSIP
2) SQGQPIPISLQ
53
94
80
104