<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12882

Description cyclin-dependent kinase E-1-like
SequenceMGDGNNNSGRGIAANNTPSSNSEKPEWLQQYNLLGKIGEGTYGLVFLARIKSPTNRGKCIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLVNVHINHADMSLYLAFDYAEYDLYEIIKLHRDKVNHAMNQYTVKSLLWQLLNGLNYLHGNWIIHRDLKPSNILVMGEGEEQGVVKIADFGLARIYQAPLKPLSENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGAEAKSTPNPFQLDQLDKIFKILGHPTLEKWPTLASLPHWQSDVQHIQSHKYENAGLHSVVHLSPKSPAFDLLSRMLEYDPRKRITAAQALEHEYFRIEPLPGRNALVPSQPGEKIVNYPTRPVDQNTDFEGTTSIQQPSQPVSSGNVAGGMGAHVGRNGSVNRPMPPPPMQRMPQGIMAYNFPSQAGVGGGINPGGMPMQRNLAAQAHQQQQLRRKDPGMGMTGYPPQQKSRRM
Length480
PositionKinase
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.08
Grand average of hydropathy-0.443
Instability index39.92
Isoelectric point9.25
Molecular weight53392.51
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12882
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.79|      26|      28|     391|     418|       1
---------------------------------------------------------------------------
  391-  418 (43.21/31.30)	GNVAGGMGAHVGRNGSVNrPmPPPPMQR
  422-  447 (50.59/27.81)	GIMAYNFPSQAGVGGGIN.P.GGMPMQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.22|      17|      28|      92|     109|       2
---------------------------------------------------------------------------
   92-  109 (25.83/20.24)	NVVKLVNVHINHAdMSLY
  121-  137 (31.39/19.54)	EIIKLHRDKVNHA.MNQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.09|      22|      28|     212|     238|       5
---------------------------------------------------------------------------
  212-  234 (37.47/23.70)	PeLLLG..AKHYTSAVDMWAVGCIF
  242-  265 (33.62/20.97)	P.LFQGaeAKSTPNPFQLDQLDKIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.08|      24|      37|     303|     327|       8
---------------------------------------------------------------------------
  303-  327 (38.25/32.42)	HSVVHLSPkSPAFDLL......SRMLEYDPR
  338-  367 (36.83/25.68)	HEYFRIEP.LPGRNALvpsqpgEKIVNYPTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12882 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALVPSQPGEKIVNYPTRPVDQNTDFEGTTSIQQPSQPVSSGNVAGGMGAHVGRNGSVNRPMPPPPMQRMPQGIMAYNFPSQAGVGGGINPGGMPMQRNLAAQAHQQQQLRRKDPGMGMTGYPPQQKSRRM
351
480










Molecular Recognition Features






MoRF SequenceStartStop




1) IAIKKF
2) QQLRRKD
3) TGYPPQQKSR
60
457
469
65
463
478