<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12875

Description ATP-dependent DNA helicase Q-like 4A isoform X1
SequenceMPDQNDSVESQKCYDKLPNVNWLRHFDAHDKFACQNKFLCTNFLFSLEGQKPQGTMFARLTSRQIQNSQIFQHTQVEKAWQILSSLPASCRTYLKPGTSAPVKTSTDEISHNRRGRSTLVELSGMKRSEHMHVHPNSSETESKVNGFGRCMTSSFPSNNANTMESGNNLRGNSGITTSMFSHSNSKVSGGSLKNQTFHGVQQEQSADVLANEIDDDDLLKLLNLGFILMQSIGHIDCIKDIDVDQIVSEHYQSTCTPQPSVSKFLPITPSVDKNAFAGQETCLPPELCSNCSHGCKLGHCPEAASHVQEMKDMLIAVSNELLDNATNLSLEQIEKLRQDRLQLNKLIQQLEKYLSDVERQKSNFSASTATLSFQYGTPQTTSLRTNPIQFDTQVHSRNEPNGYDNWNSPTVPFSSVNSIGVPSGPIEREPYIPQIIDINYIEGSNDQKWSSRDFPWTRKLEANNKKVFGNHSFRPNQREVINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMHLLQANIPAAYLSANMDWSEQQEILTELTSDYCKYKLLYVTPEKVAKSDVLLRHLNILNSRDLLARIVIDEAHCVSQWGHDFRPDYQGLGILKQKFPKTPVLALTATATASVKEDVVQALGLINCIIFRQSFNRPNLWYSVIPKTKKCVEDIDKLIKENHFDECGIIYCLSRMDCEKVAEKLQEYGHKAAFYHGNMDPAQRAFIQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCLLYYSYSDYIRVKHMISQGAAEQSPLITGHSRFNNSGRILETNTENLLRMVGYCENDVDCRRLLQLLHFGEKFNSTHCQKTCDNCCKTRSSVDKDVTNIAKQLVELIKLTGQQFSSSHILEVFRGSLSQFVKKHRHETLSLHGVGKHLAKGEASRIIHHLVVEEYLLEDVKKSDIYGSVSSVLKVNESKVKNLFSGSQAIIIRFPSTVKVGKLSKPEVTPAKGSLTTSGKLSPPIVDTPAQSQSIVDLNLSAKLYSALRMLRTILVKEAGEGVMAYHIFGNATLQHISKRVPRTKEELLEINGIGKAKILKYGDRLLETIEATIKEHYKADKISSGSSNDSNDSAKRRRNTNANIDNDDDFSRSTGRSKKRTVERQDKDGNSDNNHQYPADENDLDFDDLDYVYDVESKENRPQVEVNINGRVLPSWPRT
Length1222
PositionUnknown
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.07
Grand average of hydropathy-0.495
Instability index46.57
Isoelectric point7.54
Molecular weight137268.70
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
chromosome	GO:0005694	IBA:GO_Central
cytoplasm	GO:0005737	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IBA:GO_Central
ATP binding	GO:0005524	IEA:UniProtKB-KW
four-way junction helicase activity	GO:0009378	IBA:GO_Central
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
DNA duplex unwinding	GO:0032508	IBA:GO_Central
DNA recombination	GO:0006310	IBA:GO_Central
DNA repair	GO:0006281	IBA:GO_Central
DNA unwinding involved in DNA replication	GO:0006268	IBA:GO_Central
double-strand break repair via homologous recombination	GO:0000724	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12875
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.34|      24|     134|     451|     476|       1
---------------------------------------------------------------------------
  451-  476 (37.92/34.52)	SRDFpWTRKL..EANNKKVFGnHSFRPN
  590-  615 (42.42/27.25)	SRDL.LARIVidEAHCVSQWG.HDFRPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.93|      41|     134|     912|     986|       2
---------------------------------------------------------------------------
  753-  804 (59.45/23.80)	GMGINKPDVRFVIHHSLpksIEGYHQEcgragrDGQRSSclLYYSYSDYIRV
  937-  977 (68.48/ 8.69)	GKHLAKGEASRIIHHLV...VEEYLLE......DVKKSD..IYGSVSSVLKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.52|      55|     140|     685|     745|       4
---------------------------------------------------------------------------
  688-  745 (93.01/61.32)	ENHFDECGiiYCLSRMDCEKVAeKLQEYGHKAAFYHGNMDPAQRAFIQKQWSKDEINI
  837-  891 (100.52/51.33)	ENLLRMVG..YCENDVDCRRLL.QLLHFGEKFNSTHCQKTCDNCCKTRSSVDKDVTNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.14|      53|     275|      84|     138|       5
---------------------------------------------------------------------------
   84-  138 (84.15/53.48)	SSLPASCRTY.LKPGTSAPVKTSTDEISHNRRGRSTlVELSGMKRSEHMHVhPNSS
  362-  415 (91.99/50.40)	SNFSASTATLsFQYGTPQTTSLRTNPIQFDTQVHSR.NEPNGYDNWNSPTV.PFSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12875 with Med34 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APVKTSTDEISHNRRGRSTLVELSGMKRSEHMHVHPNSSETESKVNGFGRCM
2) DLDYVYDVESKENRPQVEVNINGRVLPSWPRT
3) SSFPSNNANTMESGNNLRGNSGITTSMFSHSNSKVS
4) YKADKISSGSSNDSNDSAKRRRNTNANIDNDDDFSRSTGRSKKRTVERQDKDGNSDNNHQYPADENDLD
100
1191
153
1120
151
1222
188
1188










Molecular Recognition Features






MoRF SequenceStartStop




NANANA