<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12873

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSSLVSRTAEEPFTSLKELVEKSKSSGQSDTEKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAVEVLLTGSYERLPKCIEDVGMQSSLTEDQQKPALKKLDTLVRSKLLEVSLPKEISEVKVADGTALIRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERSGLVKLEQMRRHVLGDDLERRMSTAENPFATLYSVLHELCVALVMDTVIRQVQALRLGRWKDAIRFELISDGGSGGSSQLNQDNESDSAAQRTPGLKLVYWLDFDKNSGASDTGSCPYIKIEPGPDLQIKCQHSTFVIDPLTGKEASFFLDQSCIDVEKLLLRAISCNRYTRLLEIQKELMKNVHICRDASDVVLLSQADEPDSEHRKEDAKLDNKEHGGQELLRVRAYGSSYFTLGINIRNGRFLLQSSQNILSSSALLEGEETLNQGTMTAVDVFSSLRSKSIIHLFAAIGRFLGLEVYEHGFAAVKVPKNLVNGSSVLIMGFPESESSYFLLMELDKDFKPLFKLLETQPDPSGKGHSFNDLNNVLRIKKIDINQMQMLEDETNLSILDWRKLLPSLPNVGGPDQISEHDVFNLDGSIQVPGGSSSSFSSIVDEVFEIEKGTSATQFPSQKISSFSSSPASHLTSVPMNLHSVKAGTPSPKWEAGLQVSQHNNVAKSSGSASHYDGSLYPSSGLKGSYNSASFGSFSSGTGRSTSAKKLSASKSEQDLASLRSPHSVDNGVLDEDQLRLLNDTSKDTLSASRSSRLLSPPRPTLPRVIAQNAKPNGPRSSSAGNLTAAVRFSGSSPLASPPVSQAAETTICHGPSHDASKHDQNPRKRKISNLLSLIPSLQYIEPDAGFSKRRKTSDVACTQQPTSQVLKSSEIISKSETYSYGNLIAEANKGNVPSGIYVSALLHVVRHSSLCIKHAKLTSQMEELDIPYVEEVGLRNASSNIWFRLPCSQGDSWRHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSTSTPWGSGIRIANTSHVDSHIRYDPDGVVLSYQSVEADSIKKLVADIRRLSNARTFALGMWKLLGVRADDKPEEGNANSDLKAPSGGKGPSEAVDKLSEHMRRSFRIEAVGLLSLWFCFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFIDGAEVASLLDCIRLTAGPLHALAAATRPARASPAPGVSGPSGVISSVPKQPGYSPLQGLLPSSSTTNVNQAAAAVPAGNTASASASSIGNHSIHGAAMLAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPSTPPRGGSYVGGSLPCPQFRPFIMEHVAQELNGLDSSFTSGQQTVGPANSNNPNLSSGPQLSANGSRVNLPTSAAMSRAANQVAGLNRVGNSLPGSPNLAVVSSGLPIRRPPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPVVALKKVLRGILKYLGVLWLFAQLPALLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNNANSQEELTQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLALTQSGDIAPAQKPRIELCLENHTGVNVGDASESSSATKSNIHYDRPHNSVDFALTVVLDPALIPHINTAGGAAWLPYCVSVRLRYSFGENPNVSFLGMEGSHGGRACWLRLDEWEKCKQRVARTVEVSGSSPADATQGRLRIVADNVQRAXHLCLQGLSHGVSKMDKNPTNSFLIISSFNF
Length1832
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.06
Grand average of hydropathy-0.236
Instability index46.27
Isoelectric point8.00
Molecular weight199173.51
Publications
PubMed=25893780

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP12873
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.38|      32|     224|    1466|    1497|       2
---------------------------------------------------------------------------
 1466- 1497 (61.89/33.07)	PGSGVPAHVR.....GELNTAIIGLGDDGGYGG..GWVP
 1697- 1727 (53.02/27.29)	PHNSVDFALT.....VVLDPALIPHINTAG.GA..AWLP
 1731- 1759 (20.47/ 6.11)	.......SVRlrysfGE.NPNVSFLGMEGSHGGraCW..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.87|      36|     224|     132|     172|       3
---------------------------------------------------------------------------
  132-  167 (60.09/37.26)	KC......IEDV.GMQSSLTEDQ.....QKPALKKLDTLVRSKLLEVS
  347-  394 (45.77/25.16)	KCqhstfvIDPLtGKEASFFLDQscidvEKLLLRAISCNRYTRLLEIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.34|      36|     224|     914|     952|       4
---------------------------------------------------------------------------
  914-  950 (54.01/46.76)	PTSQVLKSSEIISKSETYSYgNLIAEANKGNVPSGIY
  960-  995 (61.33/40.48)	HSSLCIKHAKLTSQMEELDI.PYVEEVGLRNASSNIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.14|      29|     224|    1030|    1060|       7
---------------------------------------------------------------------------
  630-  653 (35.87/12.62)	DVFNLD.GSIQVPGGSSSSF...SSIVD..
  655-  682 (35.94/15.20)	.VFEIEKGTSATQFPSQ.KISSfSSSPASH
 1032- 1060 (54.33/30.06)	DLWELQKGSTSTPWGSGIRIAN.TSHVDSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.14|      13|     220|    1226|    1240|       9
---------------------------------------------------------------------------
 1226- 1239 (19.99/17.90)	PARASPAPGVSgPS
 1248- 1260 (25.15/10.17)	QPGYSPLQGLL.PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.20|      15|      36|     759|     774|      12
---------------------------------------------------------------------------
  759-  774 (21.52/17.01)	LSASKSEQDLASLRsP
  798-  812 (27.68/17.13)	LSASRSSRLLSPPR.P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12873 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLDSSFTSGQQTVGPANSNNPNLSSGPQLSAN
2) RSTSAKKLSASKSEQDLASLRSPHSVDNGVLDEDQLRLLNDTSKDTLSASRSSRLLSPPRPTLPRVIAQNAKPNGPRSSSAGNLTAAVRFSGSSPLASPPVSQAAETTICHGPSHDASKHDQNPRKRKI
3) VPMNLHSVKAGTPSPKWEAGLQVSQHNNVAKSSGSASH
1387
752
686
1418
880
723










Molecular Recognition Features






MoRF SequenceStartStop




NANANA