<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12859

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMAEKQLIVAVEGTAAMGPYWQIILSDYLEKIIRCFCSNEFAGQKNTTSNVELSLVAFNTHGSYCACLVQRSGWTKDVDIFLQWLSAIPFSGGGFNDAAIAEGLSEALMSFDVAQMFPIAANGNQTHQIADGQRHCILVAASNPYPLPTPVYRPQTQNLEQSENMESQTESRLSDAETVAKSFPQCSVSLSVICPKQLSKLKAIYSAGNRNPRASDPPVDNVRNPQFLVLISENFMEGCAALSRSGVPSLAPNQSPVKMDMASVTSVAGTSPTSVPSVNGSIMSRQPVSVGNVPTATVKVEPATITSMANGPAFPHIPSVPRAPFQAVPTLQTSSPLTTTEEVMRSSDNVQEIKPSVGGMTQPLRPVPPAAANVNILNNLSQARVMNSAALSGGTSIGLQSMGQTPVAMHMSNMISSGMTSSVPLAQTVFSSGQSAMTSLPGSGAVTGTTQVPPNSNLNSFASATSNVAGNSNIGISQPMCNVQGAVSMGQSVPGSMSQGNHSGAQLVQTGVAMSQSMSGLGPSTVSSGTGTLIPTPGLSQQVQSGMQTIGVNNNSAASMPLSQQTSSALQSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASETLASDWPQTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLGQLQEKKLCAVIQLPSQTLMLSVSDKAYRLIGMLFPGDMVVFKPQISSQHQQQQQQMQPLLQQQQMPQQQQQQQQQLPQLQQQQQLPQLQQQQQQQPQQQQPLPHLQQQQLPQLQQQQQQQQQLSQMQQQQMPQLQQQPQLAQMPQQQQQMVGSGINSAYVQGPGRSQLVSQGQVSSQAPSNMPGGGFMS
Length842
PositionUnknown
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.05
Grand average of hydropathy-0.323
Instability index65.48
Isoelectric point8.00
Molecular weight90162.91
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12859
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     174.40|      24|      24|     720|     743|       1
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  708-  727 (36.42/ 8.71)	QMQPLLQQQQMPQ..........qQQQQQQ
  728-  753 (48.25/13.61)	QLPQLQQQQQLPQLQQ...qqQQ.QPQQQQ
  754-  774 (46.43/12.86)	PLPHLQQQQ.LPQL.......QQ.QQQQQQ
  775-  802 (43.30/11.56)	QLSQM.QQQQMPQLQQqpqlaQM.PQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.75|      24|      24|     375|     398|       2
---------------------------------------------------------------------------
  375-  398 (40.11/16.81)	ILNNLSQ........ARVMNSAA....LSGGTSIGL
  534-  569 (22.64/ 6.26)	PTPGLSQqvqsgmqtIGVNNNSAasmpLSQQTSSAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.77|      19|      24|     482|     503|       3
---------------------------------------------------------------------------
  425-  447 (26.42/ 8.77)	AQTVFSSGQsamtSLPGS...GAVTG
  482-  503 (31.35/17.99)	VQGAVSMGQ....SVPGSmsqGNHSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     158.44|      28|      28|     252|     279|       4
---------------------------------------------------------------------------
  214-  240 (31.91/11.86)	.S...DPPVDN...VRNPQFLVLISENFMEGCAA
  241-  271 (40.24/16.84)	LSrsgVPSLAP...NQSPVKMDMASVTSVAGTSP
  272-  293 (27.15/ 9.00)	TS...VPSVNGsimSRQPV.....SVGNV....P
  314-  335 (24.15/ 7.21)	PH...IPSVPR.apFQ........AVPTLQTSSP
  337-  362 (34.99/13.70)	TT...TEEVMR...SSDNVQEIKPSVGGM..TQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.98|      15|      27|      88|     102|       5
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   88-  102 (27.51/18.98)	PFSGGGFNDAAIAEG
  117-  131 (27.47/18.93)	PIAANGNQTHQIADG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.44|      10|      15|     448|     457|       6
---------------------------------------------------------------------------
  448-  457 (19.32/11.42)	TTQVPPNSNL
  464-  473 (17.12/ 9.08)	TSNVAGNSNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.59|      20|     127|     677|     701|       7
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  631-  669 (22.89/11.00)	NKQY..VG...KADFLVFRAmnqhgflgqlqekklcaviQLPSQ
  677-  701 (27.70/30.74)	DKAYrlIGmlfPGDMVVFKP...................QISSQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12859 with Med25 domain of Kingdom Viridiplantae
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