<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12858

Description mediator of RNA polymerase II transcription subunit 23-like isoform X1
SequenceMDQTQRSVAAAANSRTYQFHPARAAITDLFNLYLGVRNSRQKADDSVREPPNKTQKRVLALNRELPPRNEQFLLDFEQLQTQFGDQDQLQSVTESVLISLVIQCCSHAPRAEFLLFALRSLCSIGYVNWDTFLPSLLSSVASAEGPVSQGSQGVPSVSSSVSQSGMMPSTSVIANASNFQSANAASTLTSVHVIGSPAQSTIEPSSGATLSPVKLSNIACSGQPSTTRMDSSIRDNAISNLRQLCCKIILTGLECNLKPVTQAEIFHHMLNWLVNWDQRQHGNEECDGKSWRLEKALIEWLHSCLDVIWLLVEEDKCRVPFYELLRSGLQFIENIPDDEALFTLILEIHRRRDMMAMHMQMLDQHLHCPTFGTHRILSQTTPNVSVEGVANLRYSPITYPSVLGEPLHGEDLAASIQRGSLDWERALRCIRHAIRSTPSPDWWKRVLVVAPFYRGSVPTPGAVFTCDMICEATIDRIVELLKLTNSEINCWQEWLVFSDIFFFLMKSGCIDFVDFIDKLGSRLSASDHHILNTNHVTWLLAQIIRVEHVMTALNTDSRKVETTRKILSFHREDRSSDPNNPQSILLDFISSCQNLRIWSLNTSTREYLNNEQLQKGKQIDEWWRQVSKGERMMDYMSMDDKSIGMFWVVSYTMAQPACETVMNWLSSGGVTELLPGANVQPNERFMVMREVSPLPISLLSGFSMNLYLKLVFQMEESLFAGQVVPSIAMVETYTRLLLIAPHSLFRSHFSHLAQRNASLLSKPAVTLLVLEIVNYRLLPLYRYQGKCKPLMYDVTKIISALKGKRGDHRVFRLAENLCINLILSLRDFFSVKREGKGPTEFTETLNRITIITLAITIKTRGIADADHLLYLQTMLEQILATSQHTWSEKTLRFFPSILRDLLMTRTDKRGLAIQEWLQSETTVINQCTQLLSSSAEPNYVMTYINHSFPQHRQYLCAGAWILMQGHPENINSGNLARVLREFSPEDVTSNIYTMVDVLLHHIHIELQHGHSLQDLLLKTCANLAFFVWTHELIPLDILLLALIDRDDDPHALRIVISLLDRQELQQRVKLYCMNRGPPEHWLYTGIFKRSDLQKALGNHLSWKERYPTFFDDIVARLLPVIPLVVYRLIENDAIESADRILGMYSLFLAYHPLRFTFVRDILAYFYGHLPGKLIVRILNVLDLSKIPFSESFPQHISSSNPAICPPLEYFATLLLALVNNVIPPLNSNSRTGSMGDASNNSVRGPHNKTPATPQSGPANASEGQKAFYQIQDPGTYTQLVLETAVIEILSLPISASQIVSSLVQIVVNIQPTLIQSSNGLHGASSGAVQGSVLPTSPSGGSTDSAGRSTPSVSGINTSSFVSRSGYTCQQLSCLFIQACGLLLAQLPPEFHLQLYMEASRIIKESWWLTDGKRSLSELDSAVSYALLDPTWASQDNTSTAIGNIVALLHSFFSNLPQEWLEGTHVIIQQLRPVTSVAMLRIAFRIMGPLLPRLVTAHNLFNKILSLLLNTLVDVFGKNTQPPVPVEASEITDLIDYLHHIIHYEGQAGPVQANSKPRPEVLSICGRAAESLRPDVQHLLSHLKPDVNSSIYAATHPKIAQNPSS
Length1604
PositionTail
OrganismGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.08
Grand average of hydropathy-0.051
Instability index48.89
Isoelectric point6.45
Molecular weight179967.59
Publications
PubMed=25893780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12858
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.28|      42|     544|     914|    1009|       1
---------------------------------------------------------------------------
  914-  935 (21.38/134.78)	QEWLQSeTTVINQCTQLLSSSA..........................................................................
  989- 1009 (27.59/32.93)	......................epnyvmtyinhsfpqhrqylcagawilmqghpeninsgnlarvlrefspedvtSNIYTMVDVLLHHIHIELQHG
 1457- 1548 (54.31/ 0.00)	QEWLEG.THVIIQQLRPVTSVA...mlriafrimgpllprlvtahnlfnkilslllntlvdvfgkntqppvpveaSEITDLIDYLHHIIHYEGQAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.39|      15|      15|    1192|    1206|       2
---------------------------------------------------------------------------
 1192- 1206 (29.20/19.11)	FPQHISSSNPAICPP
 1210- 1224 (24.19/14.41)	FATLLLALVNNVIPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.76|      12|      15|    1035|    1047|       3
---------------------------------------------------------------------------
 1035- 1047 (15.25/15.36)	LDIlLLALIDRDD
 1052- 1063 (19.51/13.45)	LRI.VISLLDRQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.92|      17|      17|     422|     438|       5
---------------------------------------------------------------------------
  422-  438 (32.23/18.29)	DWERALRCIRHAIR.STP
  441-  458 (28.69/15.51)	DWWKRVLVVAPFYRgSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.27|      12|      15|     959|     970|       6
---------------------------------------------------------------------------
  959-  970 (23.81/16.81)	AWILMQGHPENI
  976-  987 (20.46/13.20)	ARVLREFSPEDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.32|      12|      15|    1147|    1161|       7
---------------------------------------------------------------------------
 1147- 1159 (18.64/21.67)	FLAYHPLRFtFVR
 1165- 1176 (22.68/10.27)	FYGHLPGKL.IVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.01|      18|      20|     169|     188|       8
---------------------------------------------------------------------------
  170-  187 (29.36/15.59)	TSVIANASNFQSA...NAAST
  189-  209 (25.65/12.24)	TSVHVIGSPAQSTiepSSGAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.12|      17|     221|     886|     902|       9
---------------------------------------------------------------------------
  886-  902 (31.50/21.84)	WSEKTLRFFPSILRDLL
 1102- 1118 (32.63/22.92)	WKERYPTFFDDIVARLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.32|       8|     121|     118|     144|      11
---------------------------------------------------------------------------
  118-  130 (10.92/16.05)	LRSLcsigyVNWD
  270-  277 (18.40/ 7.53)	LNWL.....VNWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.43|      12|      17|    1319|    1334|      16
---------------------------------------------------------------------------
 1319- 1334 (12.02/16.74)	GlhGASSGAvqGSVLP
 1339- 1350 (22.41/11.37)	G..GSTDSA..GRSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.25|      15|     181|     321|     335|      21
---------------------------------------------------------------------------
  321-  335 (27.12/16.83)	FYELLRSG.LQFIENI
  501-  516 (24.12/14.13)	FFFLMKSGcIDFVDFI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12858 with Med23 domain of Kingdom Viridiplantae
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