Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLQNVQHQLLQSPARLGLPTPSSPSLQSTTPPPKFSSQVSQPLQPNQQANVLTTTTTSSTLLPLLPPLPRAQSLLVQMSSLTSRLFEVSPNRSHWLSAFRGSFPSFLPSAAPFPQDSFPSSSKEILSVFTSLQTQLFEAVAELQEILDLQDEKQKIAREIRSNDSVILAFANKLKGAERVLDNLVDDYSDYRRPKRAKLENDTEESSVTTVATQLKLSDILSYARRISYTTFAPPEFGGGQAPLRGALPPAPQDEQMRASQLYNFADLDVGLPKTDEGKENILERLIEPLAESNPLANLSAIQGLVPPNIVVPSGWKPGMPVELPTDLPLPPPGWKPGDPIALPPVDSRPLQKVEEAPARPVPPPGLSRMPEPIQVRHVQLDIDDDSSDYSSDEASSDSED |
Length | 401 |
Position | Middle |
Organism | Capsicum annuum (Capsicum pepper) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.424 |
Instability index | 80.62 |
Isoelectric point | 4.77 |
Molecular weight | 43822.87 |
Publications | PubMed=29089032 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP12842 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.11| 18| 18| 313| 330| 1 --------------------------------------------------------------------------- 313- 330 (40.13/19.75) PSGWKPGMPVELP.TD.LPL 332- 351 (31.98/14.39) PPGWKPGDPIALPpVDsRPL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 62.56| 21| 21| 42| 62| 4 --------------------------------------------------------------------------- 42- 62 (34.30/19.32) PL...QPNQQANVLTTTTTSSTLL 63- 86 (28.26/14.72) PLlppLPRAQSLLVQMSSLTSRLF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KVEEAPARPVP 2) PGLSRMPEPIQVRHVQLDI | 353 365 | 363 383 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab