<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12830

Description mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFSGDEHGSARNIVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGNKPLPILAKKVPILSKKEDVFAYLAKYSVPLLRAAWLVKMTCAYYAAISEAKLKKRQATDPNIEWTQILTRYLREQLAKIAEFYHVTTNQGNGSVAVPQEVEQALKQWEYNEKLAFYMFQEGMLERHEYLTWILDVLEKIRPTDDDLLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDSPNLVAAHSPHMIIGSNNPPLAAPSPTTPGPMVSPVQLACSDFFSCPQHRPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSINPGSPLDLLQVAPSSLPMPGGNSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDRQEVAPNDEAVVTLLCEWAVSCKRSGKYRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLTGSSLPVFQNVLLRFLDTQAPSLSDPNSEYEKTEFVNLVLLFSEFIRHDVFSHDAYMCTLISRGDLSITTATRPRSPTGETVDEHYSKDHDMKLEDHSIMEHMGIDSGTTNIFDDVDKNDFKTDFGSEFPIFSPMPAESCENVNSSLDRRISVNSEKTVKRERLKELIFPSSYDLRHLQYATHFPILLLKWFSGGTLTTMNLEISLGCTTSTSEKYRKYDESSSHECNQRMILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFRLVGKRFYNLNSARTKTN
Length1015
PositionKinase
OrganismAlligator sinensis (Chinese alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.09
Grand average of hydropathy-0.317
Instability index51.25
Isoelectric point6.55
Molecular weight116621.64
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12830
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.40|      81|     203|     638|     733|       1
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  638-  733 (117.38/127.95)	PTGETVdehYSKDHDMK.LEDHSIMEHMGidsgtTNIFDDVdkNDFKTDFGSEFP.......IFSPMpaESCENVNSSLDRRISVNSEKTVKRErlkELIFPSS
  846-  934 (123.02/89.48)	PTLETV...FTKLQQLSyFDQHQVTSQIS.....SNVLEQI..TSFASGTSYHLPlahhiqlIFDLM..EPALNINGLIDFAIQLLNELSVVEA...ELLLKSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.40|      21|     320|     276|     298|       7
---------------------------------------------------------------------------
  276-  298 (30.97/25.09)	LMLQYSeEFVQSAYLSRRlAYFC
  599-  619 (40.43/23.27)	LVLLFS.EFIRHDVFSHD.AYMC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12830 with Med12 domain of Kingdom Metazoa
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