<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12826

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSLLERLHAKFNQNRPWTETVKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVHLDSTGLLCDVKVAHHGENPVSCPELVQHLREKNFDKFSKHLKGLVNLYKLPGDNKLKTKMYLALQSLELDLIKMASMYWQATNASPFDKILHGSVGYLTPRSGGHLMNLKYYISPYDLFEDGTGAPIALHDNNVPRSLGLNVSVTIEGTLAMYKLPIAPLIMGSHPVDNKGTPSFSSVTSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTPPAFVPLYELITQFELSKETDSVPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSMSMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSAIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKDNPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRIPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQSIPHPQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPSTNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDADDFKGYAPQPLSTLGVQVLGGDGGENKFKGSSQADTVDFSIIASASKALGSSDIMEHHSGSQSPLLSTGDLGKEKPQKRVKEGNGSGSSLSGPGLDGKPGKRSRTPSSDGKSKEKLPKRKKADTEGKSPSHSTSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVSSSSSKSHHSHSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSGSGQSKSSAQSVGKPGSSPITKHGLSSSSGGTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGPSSNSSSHTMSSKHMSGGEFQGKREKSDKDKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRERDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSSGILSADRPSRPSPDFLIGEEDDDLMDVALIGN
Length1565
PositionMiddle
OrganismAlligator sinensis (Chinese alligator)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae> Alligator.
Aromaticity0.05
Grand average of hydropathy-0.638
Instability index55.31
Isoelectric point8.94
Molecular weight166129.73
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12826
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1037.58|     164|     164|     958|    1121|       1
---------------------------------------------------------------------------
  497-  652 (112.94/31.28)	........................................................................RRKAE...TiQADTPA..LSLIAETV....EdmvkknlPPAS.....SPGYGMTTG...SN.PmsGTTTP......TNTF..P.GGPITtlfnmsmsmkerhdsVG....HGEDFSKVSqnpiltsllqitgnvgsaIGS...SPTPP........HHTPPPVSS......PASNTKNHPMLMNL..LKDNP.PQDF.STLYGSSPLE
  657-  800 (172.33/52.60)	SSGSPRM.....................EMGPG....GNKQKKKKSRIPA................DK..PKHQTEDdfqR.ELFSMD..VDSQNPIFdvnmT.......ADTLDTPHITPAPS.QCS...TP.P..TTYPQSI.PH.......P.QPSI............................QRM..................VRL...SSSDS........IGADVTDIL......SDIAEEASKLPSTN..EDCPPiGTPVRDS..SSSGHS
  812-  958 (149.84/44.52)	TNNSENP.....................YTDPA.....D.LIADAAVSPNSDS.SN..........HFF.P.....D...G.VDFNPDllNSQSQSGF....G.......EEYFDESSQ....SGDAD...DF.K..GYAPQPL.STLGVQVlgG.DGGEN...............KFKGSSQAD.TVDFS..................IIA...SASKAlgssdimeHHSGSQSPL......LSTGDL.GKEKPQKrvKEG..................
  959- 1121 (283.09/92.35)	.NGSGSS.....................LSGPG....LDGKPGKRSRTPSSDGKSK..........EKL.PKRKKAD...T.EGKSPS..HSTSNRPF....T.......PPASTGGSKSPGSSGRSQ...TP.P..GVATPPI.PKITIQI..P.KGTVT...............VGKPSSHGQYTSSGS..................VSS...SSSKS........HHSHSSSSS......SSSSSTSGKIKSSK..SEGSS.GSKMSSSLYSSQGGS
 1134- 1270 (179.81/55.28)	GKPGSSP.....................ITKHG....LSSSSGGTKMKP..QGKPS..........SLMnPSMSKPN...I....SPS..HS...RP.................SGGSDKLASPMK......PvP..G..TPPS.SK.......A.KSPIS...............SGSGGSH....MSGT..................GSS...SSMKS........SSGMGSSGSmsqkppPSSNSSTA...SSS..SFSSS.GSSMSSS....QNQH
 1271- 1448 (139.57/40.84)	GSSKGKSpsrnkkpsltavidklkhgvvTSGPGgedpMDGQMG.....PSSNSSSHtmsskhmsggEFQ.GKREKSD...K.D.KSKV...SVSGGSV....D.......SSKKTSDSKNVGSTGVAKiiiSK.H..DGGSPSIkAKVTLQK..PgEG...................GGDSLRPQMASSKS..................YGSpliSGSTP........KHERCSPSH......SKSPAYTPQNIDSE..SE...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     228.37|      88|     164|      37|     137|       2
---------------------------------------------------------------------------
   37-  135 (133.34/133.50)	SGGH....QHLVSCLETLQKAlkvSSLP.AMTDrlESIARQNGLGSHLSANGT...................................................................................................................................................................................eCYITSDMFYVEV.HLDSTGLLC...DVKVAHHgenpVSCpELVQHLREK..NFDKF
  200-  247 (45.42/23.78)	SGGHlmnlKYYISPYDLFEDG...TGAPiALHD..NNVPRSLGLNVSVTIEGT............................................................................................................................................................................................................................................
  428-  478 (49.61/23.93)	.....................................................lamyklpiaplimgshpvdnkgtpsfssvtsansvdlpacfflkfprpipvsrafiqklqsctgiplfdtppafvplyelitqfelsketdsvplnhnmrfyaalpgqqhcyflnkdaplpdgrslqgtliskiafqhpgrvplilnlirhqvayntligscvkrtvlkedspgilqfevCPLSDSCFSVSFqHPVNDSLVCvvmDVQDSTH....VNC.KLYKGLSDAliCTDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.70|      14|      83|    1449|    1462|       5
---------------------------------------------------------------------------
 1449- 1462 (23.74/ 8.38)	SGSSIAEKSYQNSP
 1533- 1546 (22.96/ 7.85)	SGILSADRPSRPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.17|      39|      47|     307|     346|       6
---------------------------------------------------------------------------
  307-  333 (41.21/22.01)	.......................QSCTGIPLF..DTP.PAFVPLY.EL.ITQFEL
  335-  383 (50.71/30.54)	KETDSVPLNHNM..rfyaalpgqQHCYFLNK...DAPlPDGRSLQgTL.ISKIAF
  384-  426 (29.24/10.21)	QHPGRVPLILNLirhqvayntliGSCVKRTVLkeDSP...........gILQFE.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12826 with Med1 domain of Kingdom Metazoa
Unable to open file!