<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12823
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MTWWLGVITAGWAPAAAPVERSMEPEHGAGSLPRPGRVGGRRDSGKLISTNALMEKLRLKYAQTPWSETLKLVRICMDKPVQGSSAVTADRPLFSCLEKIQKTLNAKSLAAMMNQLECLSKQKGLNSYISPNGTSCYITSDMFYVEVQLEKDGKVIDVKLAHPGEAPVICEDLLQHLRMKDYAAFGKILEDLSNLYQIPGNSDMKAKAYLALQSLEKDLCSMSLLYSTRDVNRVTEVLHGKVGHLVPRTGGTPMNIEFYISPYQALEEELNPGSHICGTKLFVTVGGSDTTHKLPISPLIEDSQTEDGGRLLRLEEKPIQNRKPVFLTLSDELGMDLPACFFLKFHQPSPISSSSINKIEKLTGIPIVAPTLAPLYELIVQFTLNGKYKEDCSINNSYFIVSLPDCPKHSYFINKGTEKSGITGALVSKIPFTHPKFMPAIIDILRHQMVYNTLISSCVSENSINKDYSELLYFEVSPVKDTSFSISFQHPVGVNLACVVINVLSCKEIKCSLHINPQDATLNCSNDFITRVVERCLSVPLVMRAIFKNAVNLEADGRTQNMEVVREQNPEVTCEQSASCNNIKENMSASSTHNATVTNMQNLTVTIKESFSTTNLQISSTIIEENSSTASQHSSDGIEGRQAGCRNTASFI |
Length | 599 |
Position | Middle |
Organism | Alligator sinensis (Chinese alligator) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Archelosauria> Archosauria> Crocodylia> Alligatoridae> Alligatorinae>
Alligator.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.166 |
Instability index | 45.56 |
Isoelectric point | 6.34 |
Molecular weight | 71919.74 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP12823
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 309.36| 104| 246| 14| 137| 1
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19- 137 (151.84/158.45) VERSMEP.EHGAGSlPRPGRVGGRRDSGKLiSTNALMEKlrlkyAQT.PWSETLKLVR..ICMDKPV..QGSSAVTADRPlfSCL.EKIQKTLNAKSlaAMMNQLECLSkqkGLnSYISPNGTSCY
266- 376 (157.52/105.70) LEEELNPgSHICGT.KLFVTVGGSDTTHKL.PISPLIED.....SQTeDGGRLLRLEEkpIQNRKPVflTLSDELGMDLP..ACFfLKFHQPSPISS..SSINKIEKLT...GI.PIVAPTLAPLY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.73| 11| 37| 583| 593| 2
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583- 593 (20.02/14.68) IKENMSASSTH
623- 633 (19.71/14.33) IEENSSTASQH
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