<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12821

Description mediator of RNA polymerase II transcription subunit 25 isoform X7
SequenceMCRIPIYFVLDVVDKSLFDLKRPPDGFVVPILIVSWCGNRRDRDKTASSRMPRTNMAALASAEAARRPARASASRKRTSVGPGTATAAAALAGAARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRNHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLNGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPVDVSQDPRHMVLVRGLVLPVGGSSVPGPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMQAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length839
PositionUnknown
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.05
Grand average of hydropathy-0.209
Instability index56.28
Isoelectric point9.28
Molecular weight88273.50
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12821
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.02|      27|      31|     695|     722|       4
---------------------------------------------------------------------------
  679-  704 (33.11/ 6.25)	APQPQPQGAVG.........asvaaGQPQPQGTTQ
  705-  730 (40.69/13.20)	APTGAPQGPPGTA..PGpPP....sG...PILRPQ
  800-  826 (38.23/ 8.64)	LPQRAPL..PGQMllSG.GP.....RGPVPQPGLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.43|      49|     111|     323|     374|       5
---------------------------------------------------------------------------
  282-  327 (37.52/ 6.04)	..........PR................KLPALRLLF.....EKAAPPAMLEPLQPPVDVsqdP........rhmvlvrgLVLPV
  328-  384 (77.51/27.10)	GGSSVpGPlqPK................QPVPLPPAA.....SSAAPQQALPPVPPQYQV...PGNLS.AAQ...vaaqnAVEAA
  404-  466 (49.40/10.90)	AASAV.GP....pfsqapapplapgppgAPKP.PPASqpslvSTVAPGTGL...APTAQ....PGTPSmQAG........TVAP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.13|      21|     111|     136|     166|       6
---------------------------------------------------------------------------
  109-  132 (31.48/26.92)	GGLVADVVFvieGTANLGPYFEEL
  146-  166 (39.65/15.44)	GGPPAETDF...GGDYGGTQYSLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.17|      15|      16|     732|     746|       7
---------------------------------------------------------------------------
  732-  746 (29.18/10.88)	P..GANPQLRSLLLNPP
  748-  764 (25.99/ 8.87)	PqtGVPPPQASLHHLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.50|      27|      27|      40|      66|       8
---------------------------------------------------------------------------
   40-   66 (46.30/30.26)	RRDRDKTASSRMPRTNMAALASAEAAR
   70-   96 (44.21/28.55)	RASASRKRTSVGPGTATAAAALAGAAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.23|      43|     104|     523|     565|      10
---------------------------------------------------------------------------
  523-  565 (79.08/42.08)	QVYVNHGENLKT............EQWPQ......KLIMQ..LIPQQLL................TTLGPLFRN.SRMVQ
  567-  631 (24.35/ 7.87)	HFTNKDLESLKGlyrimgngfagcVHFPHtapcevRVLM........LLysskkkifmglipydqS..G..FVN.G..IR
  632-  672 (55.80/27.53)	QVITNHK...QV............QQ..Q......KLEQQrgMGAQQAL................PGLGPILEDqARPPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12821 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMQAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
334
637
483
837










Molecular Recognition Features






MoRF SequenceStartStop




NANANA