<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12817

Description mediator of RNA polymerase II transcription subunit 25 isoform X1
SequenceMCRIPIYFVLDVVDKSLFDLKRPPDGFVVPILIVSWCGNRRDRDKTASSRMPRTNMAALASAEAARRPARASASRKRTSVGPGTATAAAALAGAARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRNHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLNGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPVDVSQDPRHMVLVRGLVLPVGGSSVPGPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMQAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLSSQLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKKEGEGRVFREKWERDYFFVEVKSMPTCLICKKNVSVLKEYNLKRHYESQHSKSYDQYTAQNRDMVLQELKRALRASEALENQE
Length898
PositionUnknown
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.06
Grand average of hydropathy-0.309
Instability index55.51
Isoelectric point9.43
Molecular weight95830.86
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12817
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     144.94|      26|      27|     415|     440|       3
---------------------------------------------------------------------------
  352-  383 (34.25/ 7.94)	A...............................PQQALPP.V....PPQYQVPgnlsaaQVAA.QNAVEA
  384-  440 (38.78/10.08)	AknqkaglgprfspinplqqaasavgppfsqaPAPPLAP.G....PPGAPKP......PPAS.QPSLVS
  443-  470 (33.92/ 7.79)	A...............................PGTGLAPtA....QPGTPSM......QAGTvAPGGVS
  697-  723 (37.98/ 9.70)	A................................GQPQPQ.GttqaPTGAPQG......PPGT.APG..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     151.33|      26|      59|     724|     749|       5
---------------------------------------------------------------------------
  297-  326 (31.03/ 9.04)	PPA...MLEPlqppvdvsQDPRHMVLVRGLVL..P
  670-  685 (28.12/ 7.49)	P........P........QNLSSQLQLRA...PQP
  724-  749 (50.19/19.26)	PPSGP.ILRP........QNPGANPQLRSLLLNPP
  784-  808 (41.98/14.88)	PQLGPqLLHP..........PPAQSWPTQLPQRAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.86|      24|      25|     557|     580|       7
---------------------------------------------------------------------------
  557-  580 (41.65/26.68)	LFRNSRMVQF.HFTNKDLESLKGLY
  586-  608 (33.88/20.43)	GF..AGCVHFpHTAPCEVRVLMLLY
  633-  651 (25.33/13.56)	VITNHKQVQ.....QQKLEQQRGM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.13|      21|     111|     136|     166|       8
---------------------------------------------------------------------------
  109-  132 (31.48/30.12)	GGLVADVVFvieGTANLGPYFEEL
  146-  166 (39.65/17.29)	GGPPAETDF...GGDYGGTQYSLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.09|      49|      72|     173|     222|       9
---------------------------------------------------------------------------
  173-  222 (83.80/57.62)	CAPESYVqCHAPTSSAYEFVTWLNGIKFMGGGGESCSLIAEGLSTALQLF
  243-  291 (85.29/54.17)	CNSPPYL.LPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.62|      23|      31|      49|      77|      10
---------------------------------------------------------------------------
   49-   71 (42.78/32.05)	SRMPRTNMAALASAEAAR.......RPARA
   79-  108 (34.84/13.60)	SVGPGTATAAAALAGAARgmvpgseGPARA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12817 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMQAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLSSQLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKKEGEG
334
637
483
820










Molecular Recognition Features






MoRF SequenceStartStop




NANANA