<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12814

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMAAPDPGRWGECGPRQPGRLGARGGQEPGAVLGAVGMMDLAYVCEWERWTKSTYCPSLPLACAWSCRNLIAFTTDLRNDDQDLTRMIHILDTEHPWEVHSISSGHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSQVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVAAADGSSASPVKFYKVCVSVVSEKCRIDTEILPSLFMRCTTDPNRKDRFPAITHLKFLARDMSEQVLLCASSQTSSLVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFQDGSVHMVHRLSLQTMAVFYSSTPRSLDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSLGHPLEPKLALQHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVERLHEEYTRQKPALQQVLSTRILAMKASLCKLSPCTVARVCDYHTKLFLMAITSTLKSLLRPHFLNTPDKSPGDRLAEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLVSLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEGLVDECCLLPSQLLVPSLDWLPASDGLVSRLQPKQPLRLRFGRAPTLPSNTSTLQLDGLARAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNKATAVKQWEQRWIKNCLCGGLWRRVPSAVPESPRRAPLSCA
Length876
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.07
Grand average of hydropathy-0.029
Instability index51.53
Isoelectric point8.39
Molecular weight96657.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12814
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.44|      47|     187|     108|     156|       1
---------------------------------------------------------------------------
  108-  154 (84.82/54.86)	AITCLEW...DQSGSRL.L..SADADGQIKCWSM.ADHL..AN.SWESSV....GSQVEGD
  158-  203 (43.50/29.96)	...ALSW...LHNGVKLaL..HVEKSGAS...SF.GEKF..SRvKFSPSLtlfgGKPMEG.
  304-  356 (56.12/32.11)	AITHLKFlarDMSEQVL.LcaSSQTSSLVECWSLrKEGLpvNN.IFQ.QI.....SPVVGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.95|      32|      37|     745|     781|       2
---------------------------------------------------------------------------
  745-  781 (56.11/39.21)	PSQLLVPSLDWLPASDGlvsrlQPK.QPL.RLRFGRAPT
  783-  816 (51.84/27.10)	PSNTSTLQLDGLARAPG.....QPKiDHLrRLHLGAYPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.64|      51|      96|     439|     493|       3
---------------------------------------------------------------------------
  439-  493 (85.00/66.12)	DEPALKRPRTTgpavHFKAMQLSWTSLALVGI....DNHGKLSMLRISPSLGHPLEPKL
  538-  592 (82.64/54.20)	QKPALQQVLST....RILAMKASLCKLSPCTVarvcDYHTKLFLMAITSTLKSLLRPHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.19|      17|     140|     223|     267|       4
---------------------------------------------------------------------------
  205-  221 (27.43/29.67)	IAVTVSGLVTV........SLLKPS
  243-  267 (23.76/13.84)	IAFTGGGNIVVaaadgssaSPVKFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.72|      19|     795|      45|      63|       6
---------------------------------------------------------------------------
   45-   63 (42.05/23.05)	EWE.RWTKSTYCPSL...............PLACA
  842-  876 (28.67/13.44)	QWEqRWIKNCLCGGLwrrvpsavpesprraPLSCA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12814 with Med16 domain of Kingdom Metazoa
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