<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12812

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQPTSSLPTAPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKQGTAPPSTEERKKKSTKGKKRSQPATKSEDYGMGPGRSGPYGVTVPPDLLHHGNPGSISHLNYRQNSLGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQPQPQQPHQQQQQTAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2090
PositionKinase
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.06
Grand average of hydropathy-0.548
Instability index58.56
Isoelectric point6.78
Molecular weight246949.70
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12812
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     264.43|      18|      18|    2056|    2073|       1
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 2056- 2073 (42.71/15.55)	QQQQQQQQQQQQQQQ.......QQQ
 2077- 2094 (42.71/15.55)	QQQQQQQQQQQQQQQ.......QQQ
 2095- 2114 (35.78/11.83)	QQQQQQQQQQQQQQY.....hiRQQ
 2115- 2132 (37.68/12.85)	QQQQILRQQQQQQQQ.......QQQ
 2133- 2150 (41.05/14.66)	QQQQQQQQQQQPQPQ.......QPH
 2151- 2168 (34.21/10.99)	QQQQQTAPPQPQPQS.......QPQ
 2169- 2193 (30.28/ 8.88)	FQRQGLQQTQQQQQTaalvrqlQQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     650.77|     208|     231|     179|     409|       2
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  179-  409 (335.19/238.69)	NTAdpFTEWTQI....ITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLAlQLDGVSSHSShviSAQPTSSLPTAPAPQPPTSSTPSTPfSDLLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH.......YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PE
  411-  646 (315.58/175.21)	NSA..FTQQVRAklreIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERCG.ESEAADEKGS...VASGSLSAPSAPIFQDVLLQFLDTQ.APMLTDPRsesERVEFFNL......VLLFCE..LIRHdvfshnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     517.15|     100|     226|    1722|    1821|       3
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  682-  722 (33.06/ 9.24)	.................KPDFSLFSP...TMPCEGKG....SPS.PEKPDVE..KEV......KPPPKE....KIEGT.........................................................
 1640- 1713 (63.25/25.31)	............................LPLPKQNRDvitcEPQ.GSLIDTKgnKIA......GFDSIF....KKEGL.........QVSTKQK..ISPW.DLFE..G.LKP....S..TAPlswawFG.TVRVD
 1722- 1821 (177.86/86.33)	QQRLLLYHTHLRP....RPRAYYLEP..LPLPPEDEE....PPA.PALLEPE..KKA......PEPPKT....DKQGTAPPSTEERKKKSTKGKKRSQPA.TKSEDYG.MGP....G.RSGP.....YGVTVPPD
 1838- 1948 (125.26/58.33)	QNSLGLY.TQNQPlpagGPRVDPYRPvrLPMQKLPTR....PTY.PGVL.PT..TMTtvmglePSSYKTsvyrQQQPTVPQG..QRLRQQLQAKIQSQGMlGQSSVHQ.MTP.......SSS.....YGLQTSQG
 1959- 2055 (117.72/54.32)	QQ.....HTG........PAGTMVPPsySSQPYQSTH....PSTnPTLVDPT..RHL......QQRPSG....YVHQQAP..TYGHGLTSTQ.RFSHQTL.QQTPMMGtMTPlsaqGvQAGV.....RSTSILPE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     569.91|     194|     226|     746|     970|       4
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  746-  970 (277.39/257.05)	SCSHeCNQRLVVLFGvgkqrdDarhAIKKITKDIlkVLNRKGTAETDQLAP...IVPL.NPGDLTFLGGEDGQKRRRNRPEAFPTaedIFAKFQH..LSHYDQHQVTaQVSrnVL.EQITSFALGMSYH.LPLVQHV.......QFIFDLMEYSLSISGLiDFAIQLLNELSVVEAELLLKSSDLVgsyttsLCLCIVAVLRhyHACLilnqDQMAQVFEGL.CGVVKHGMN.......RSDG........SSAER
  982- 1206 (292.52/190.15)	SCSH.LKSKFGELFS......D...FCSKVKNTI..YCNVEPSESNMRWAPefmIDTLeNPAAHTFTYTGLGKSLSENPANRYSF...VCNALMHvcVGHHDPDRVN.DIA..ILcAELTGYCKSLSAEwLGVLKALccssnngTCGFNDLLCNVDVSDL.SFHDSLATFVAILIARQCLLLEDLI......RCAAIPSLLN..AACS....EQDSEPGARLtCRILLHLFKtpqlnpcQSDGnkptvgirSSCDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     471.77|     154|     198|    1234|    1399|       5
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 1234- 1399 (242.80/144.30)	AELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLcedSNDLQDPVLSSAQAQRLMQliCYPHRLLdnedgENPQRQRIKRILKNLD......QWTMRQSSLELQLMIKQT....PNNEMNS....LLENIAKATIEVFQQSAETGS
 1434- 1606 (228.98/113.43)	AKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASL...HSQVHQIVINWRENQYLDD..CKPKQLM.....HEALKLRLNLVGGMFDtvqrstQQTTEWAQLLLEIIISGTvdmqSNNELFTtvldMLSVLINGTLAADMSSISQGS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12812 with Med12 domain of Kingdom Metazoa
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