<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12811

Description mediator of RNA polymerase II transcription subunit 25 isoform X3
SequenceMCRIPIYFVLDVVDKSLFDLKRPPDGFVVPILIVSWCGNRRDRDKTASSRMPRTNMAALASAEAARRPARASASRKRTSVGPGTATAAAALAGAARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRNHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLNGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPVDVSQDPRHMVLVRGLVLPVGGSSVPGPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMQAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKKEGEGRVFREKWERDYFFVEVKSMPTCLICKKNVSVLKEYNLKRHYESQHSKSYDQYTAQNRDMVLQELKRALRASEALENQE
Length895
PositionUnknown
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.06
Grand average of hydropathy-0.304
Instability index55.24
Isoelectric point9.43
Molecular weight95528.58
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12811
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.44|      22|      25|     421|     445|       2
---------------------------------------------------------------------------
  425-  452 (23.31/ 7.72)	PG.APKPPPASqPsLVSTVAPGtglAPtA
  714-  736 (37.13/ 6.36)	PGtAPGPPPSG.P.ILRPQNPG...AN.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.05|      22|      25|     661|     685|       3
---------------------------------------------------------------------------
  346-  367 (35.85/ 7.17)	PA.ASSAAPQQA.LPPVPPQYQVP
  662-  685 (33.20/14.66)	PIlEDQARPPQNlLQLRAPQPQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.68|      22|      55|     397|     418|       4
---------------------------------------------------------------------------
   90-  106 (24.90/ 7.24)	ALAG..........AARGMVPG.SEGPA.
  397-  418 (40.84/16.88)	PINPLQQ.......AASAVGPPFSQAPAP
  480-  507 (30.94/10.89)	PALGGQQsvsnkllAWSGV.LEWQEKPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.25|      27|      29|     282|     310|       5
---------------------------------------------------------------------------
  282-  308 (50.96/25.97)	PRKLPALRLLFEKAAPPAMLEPLQP..PV
  314-  342 (42.29/15.60)	PRHMVLVRGLVLPVGGSSVPGPLQPkqPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.75|      42|      70|     539|     588|       7
---------------------------------------------------------------------------
  539-  588 (62.34/67.38)	QKLIMQLIP.QQ..LLTTLGPLFRNSRMVQfhftNKDLESLKGlyriMGNGFA
  612-  656 (65.41/46.69)	KKIFMGLIPyDQsgFVNGIRQVITNHKQVQ....QQKLEQQRG....MGAQQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.13|      21|     111|     136|     166|       8
---------------------------------------------------------------------------
  109-  132 (31.48/28.37)	GGLVADVVFvieGTANLGPYFEEL
  146-  166 (39.65/16.17)	GGPPAETDF...GGDYGGTQYSLV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.76|      19|      23|      40|      62|      11
---------------------------------------------------------------------------
   40-   58 (35.03/24.42)	RRDRDKTAS....SRMPRTNMAA
   66-   88 (27.73/ 9.67)	RRPARASASrkrtSVGPGTATAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.70|      14|      17|     781|     794|      19
---------------------------------------------------------------------------
  781-  794 (27.99/10.64)	PQLGPQLLHPPPAQ
  797-  810 (25.71/ 9.12)	PTQLPQRAPLPVAK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12811 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMQAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKKEGEG
334
637
483
817










Molecular Recognition Features






MoRF SequenceStartStop




NANANA