<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12809

Description mediator of RNA polymerase II transcription subunit 14 isoform X2
SequenceMAPVQLDNHQLIPPGGGGSSGSASAPAPQPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELLVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQEMKAILRNFNANENSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQTTLEDMEKCVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVSTADREDSPVMALLLQQFKDNIQDLISYTKTGKQTRTGTKHKLSDDPCPVECKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHNTINQSPSMIHTQSPGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARLPGMSPANPSLHSPIPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1407
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.07
Grand average of hydropathy-0.180
Instability index50.66
Isoelectric point8.76
Molecular weight156405.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12809
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.46|      30|      30|      65|      94|       1
---------------------------------------------------------------------------
   65-   94 (47.54/33.28)	LVLTDLLPRKSDVERKIEIVQFASRTRQLF
   98-  127 (49.92/35.32)	LALVKWANDAGKVEKCAMISSFLDQQAILF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.11|      22|      29|    1329|    1357|       2
---------------------------------------------------------------------------
  982- 1009 (40.38/19.35)	PPS...PIGGDMMDSlisqlqPPQQQPFPKQ
 1333- 1357 (36.73/24.49)	PVSiivPIIYDMASG......TTQQADIPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      14|      29|     166|     179|       4
---------------------------------------------------------------------------
  166-  179 (26.30/12.76)	RLPTCIRDKII....PPD
  192-  209 (19.19/ 7.47)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      29|     357|     368|       5
---------------------------------------------------------------------------
  357-  368 (20.47/12.54)	IKIDENDVSKPL
  388-  399 (20.28/12.35)	MKIDHLSIEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.57|      19|      30|    1107|    1125|       6
---------------------------------------------------------------------------
 1106- 1124 (38.11/19.10)	TMPTNM............PPPRKLP..QRSWAA
 1125- 1157 (20.45/ 6.67)	SIPTILthsalnilllpsPTPGLVPglAGSYLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.63|      26|      34|    1010|    1041|       7
---------------------------------------------------------------------------
 1011- 1041 (41.94/32.03)	GTSGAYPlTSPPTSYHNTINQSPSMihtqSP
 1057- 1082 (50.69/21.34)	GRAGNWP.GSPQVSGPSPAARLPGM....SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.74|      20|      36|     291|     310|       8
---------------------------------------------------------------------------
  291-  310 (38.62/25.76)	YNCLHCFCLSL.QLEVLHSQT
  327-  347 (29.12/17.51)	YHAGKCLSLSVwNQQVLGRKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      36|    1200|    1214|       9
---------------------------------------------------------------------------
 1200- 1214 (21.47/18.23)	LKCRVALSP.KTNqTL
 1238- 1252 (22.14/12.84)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.85|      28|      34|     507|     538|      10
---------------------------------------------------------------------------
  507-  538 (42.20/33.77)	IKHLPT..ITTETLQLSNYSTHpignLSKNKLFI
  540-  569 (45.65/26.04)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.07|      12|      34|     441|     452|      11
---------------------------------------------------------------------------
  441-  452 (23.64/15.04)	LEPCGNSECLHI
  476-  487 (22.43/13.90)	MEKCVNDDMKRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.67|      30|     444|     128|     162|      13
---------------------------------------------------------------------------
  128-  162 (47.42/37.44)	VDTADRlaslaRDALVHA.RLPSF..AIPYAIDVLTTG
  571-  603 (44.25/25.18)	VSTADR.....EDSPVMAlLLQQFkdNIQDLISYTKTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.92|      22|      24|    1282|    1305|      19
---------------------------------------------------------------------------
 1282- 1305 (33.84/28.37)	ATQLKWNVQFCLTIPPSAPpIaPP
 1309- 1330 (37.08/20.74)	AVVLKSKMLFFLQLTQKTS.V.PP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12809 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHNTINQSPSMIHTQSPGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARLPGMSPANPSLHSPIPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
968
1123










Molecular Recognition Features






MoRF SequenceStartStop




NANANA