<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12808
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSRNNVLVSSPLSFIPQRVAPGSPTREEKQLEASLDALLNQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADVAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGASGLQQVQMAGAPNQQQTMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRLEALQESTGQGDAIW |
Length | 306 |
Position | Head |
Organism | Mesocricetus auratus (Golden hamster) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea>
Cricetidae> Cricetinae> Mesocricetus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.514 |
Instability index | 48.84 |
Isoelectric point | 6.14 |
Molecular weight | 33227.14 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP12808
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.12| 24| 27| 82| 107| 1
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82- 107 (32.85/30.00) LNKVLKHeKTPLFRNQViIP..LVLSPD
112- 137 (38.27/24.65) LMRQTEG.RVPVFSHEV.VPdhLRTKPD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 86.49| 28| 36| 197| 232| 2
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201- 232 (49.35/37.73) TNALVAAvafgKGLSNWRPSGS........SG..PGQPGQPG
234- 271 (37.14/13.34) GTILAGA....SGLQQVQMAGApnqqqtmlSGvqMAQAGQPG
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