<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12806

Description mediator of RNA polymerase II transcription subunit 25 isoform X5
SequenceMCRIPIYFVLDVVDKSLFDLKRPPDGFVVPILIVSWCGNRRDRDKTASSRMPRTNMAALASAEAARRPARASASRKRTSVGPGTATAAAALAGAARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRNHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLNGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPVDVSQDPRHMVLVRGLVLPVGGSSVPGPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMQAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKKEGEGRVFREKWERDYFFVEVKSMPTCLICKKNVSVLKEYNLKRHYESQHSKSYDQYTAQNRDMVLQELKRALRASEALENQE
Length871
PositionUnknown
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.06
Grand average of hydropathy-0.302
Instability index55.03
Isoelectric point9.47
Molecular weight93031.74
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12806
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     899.58|     242|     270|     268|     537|       2
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   68-  266 (177.49/45.14)	....................................................................................PAR....ASASRKRT..SVG...............PGTATAAAAlagAARGMVPGS.EGPARAGGLVADVVFVIE....GTANLGPYFEE..LRNHYLLPaieyfngGPPA.ETDfggDYGGTQYSLVvfNTV....DCAPESyvQCHAPTSSAYEFVTwlNGIK.....FM...................G....GGGESCS..LIAegLSTALQLFDDFKkmreqigqthrvcllicnsppyllPA.VESTT............Y....SG.CTTESL
  268-  537 (399.79/146.29)	QKigergIHFSIVSPRKLPALRLLFEKAAPPAM......LEPLqppvdvsqdprhmvlvRGLvLPVGGSSVPGPLQPKQPVPLPPAA....SSAAPQQALPPVPpqY..........QVPGNLSAAQV...AAQNAVEAAkNQKAGLGPRFSPINPLQQ....AASAVGPPFSQ..APAPPLAP.......GPPG.APK...PPPASQPSLV..STVAPGtGLAPTA..QPGTPSMQAGTVAP..GGVSGPSPAQL...................GAPALGGQQSVSnkLLA..WSGVLEWQEKPK........................PASVDANTKLTR..SLPCQVYVNHGEN.LKTEQW
  539-  800 (322.30/93.10)	QK.....LIMQLIPQQLLTTLGPLFRNSRMVQFhftnkdLESL................KGL.YRIMGNGFAGCVHFPHTAPCEVRVlmllYSSKKKIFMGLIP..YdqsgfvngirQVITNHKQVQ......QQKLE....QQRGLQLR.AP.QPQPQgavgASVAAGQPQPQgtTQAPTGAP......qGPPGtAPG...PPP.SGPILR..PQ.NPG......A..NPQLRSLLLNPPPP..QTGVPPPQASLhhlqppgapallppphqslGQPQLGPQ......LLH............PP........................PAQ.SWPTQLPQraPLPVAKRKKEGEGrVFREKW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12806 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMQAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKKEGEG
334
637
483
793










Molecular Recognition Features






MoRF SequenceStartStop




NANANA