<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12805

Description mediator of RNA polymerase II transcription subunit 25 isoform X4
SequenceMCRIPIYFVLDVVDKSLFDLKRPPDGFVVPILIVSWCGNRRDRDKTASSRMPRTNMAALASAEAARRPARASASRKRTSVGPGTATAAAALAGAARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRNHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLNGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPVDVSQDPRHMVLVRGLVLPVGGSSVPGPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKKEGEGRVFREKWERDYFFVEVKSMPTCLICKKNVSVLKEYNLKRHYESQHSKSYDQYTAQNRDMVLQELKRALRASEALENQE
Length894
PositionUnknown
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.06
Grand average of hydropathy-0.301
Instability index55.51
Isoelectric point9.43
Molecular weight95400.45
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12805
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.89|      21|      25|     683|     705|       4
---------------------------------------------------------------------------
  403-  425 (32.59/ 6.32)	QAASAVGPPFSQA..PAP...PlaPGPP
  688-  713 (32.30/ 9.10)	GASVAAGQPQPQGttQAPtgaP..QGPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     135.19|      31|     111|     136|     166|       5
---------------------------------------------------------------------------
  110-  146 (42.86/16.30)	GL.VADVVFvieGTANLGPYFEELrnhYL...L...PAIEYFNG
  147-  166 (28.19/ 8.48)	GP.PAETDF...GGDYGGTQYSLV....................
  470-  503 (34.02/11.59)	GPsPAQ..L...GAPALGGQQS.V.snKL...LawsGVLEWQEK
  504-  527 (30.12/ 9.51)	PK.PASVDA...NTK.............LtrsL...PCQVYVNH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.35|      32|      66|     651|     682|       6
---------------------------------------------------------------------------
  651-  682 (59.28/18.34)	GAQQALPGLGPILEDQ...ARPPQNLLQLRAPQPQ
  714-  748 (54.07/16.07)	GTAPGPPPSGPILRPQnpgANPQLRSLLLNPPPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.14|      40|      68|     186|     227|       7
---------------------------------------------------------------------------
  186-  227 (64.94/50.35)	SSAYEFVTWLNGIKFMGGGGESCSLIAEGLSTALQLFddFKK
  255-  294 (68.20/45.97)	STTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLL..FEK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.50|      27|      27|      40|      66|       9
---------------------------------------------------------------------------
   40-   66 (46.30/28.05)	RRDRDKTASSRMPRTNMAALASAEAAR
   70-   96 (44.21/26.45)	RASASRKRTSVGPGTATAAAALAGAAR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.88|      17|      59|     295|     311|      10
---------------------------------------------------------------------------
  295-  311 (32.73/13.18)	AAPPAMLEPLQP....PVDVS
  351-  371 (28.16/10.16)	AAPQQALPPVPPqyqvPGNLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.51|      26|      26|     563|     588|      11
---------------------------------------------------------------------------
  563-  588 (45.95/34.84)	VQF.HFTNKDLESLKGLYRIMGNGFAG
  590-  616 (37.56/27.01)	VHFpHTAPCEVRVLMLLYSSKKKIFMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.70|      14|      17|     780|     793|      12
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  780-  793 (27.99/10.95)	PQLGPQLLHPPPAQ
  796-  809 (25.71/ 9.37)	PTQLPQRAPLPVAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.54|      10|      16|       3|      12|      13
---------------------------------------------------------------------------
    3-   12 (18.47/10.84)	RIPIYFVLDV
   22-   31 (20.07/12.51)	RPPDGFVVPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12805 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPLQPKQPVPLPPAASSAAPQQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASAVGPPFSQAPAPPLAPGPPGAPKPPPASQPSLVSTVAPGTGLAPTAQPGTPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGAQQALPGLGPILEDQARPPQNLLQLRAPQPQPQGAVGASVAAGQPQPQGTTQAPTGAPQGPPGTAPGPPPSGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPQLLHPPPAQSWPTQLPQRAPLPVAKRKKEGEG
334
636
482
816










Molecular Recognition Features






MoRF SequenceStartStop




NANANA