<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12803

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLISEEHLHMAQSSPAPFQVLVSPYGLNGTLTGHAYKMSDPATRKLIEEWQYFYPMVLRKKEESREEAELGYDDDFPVAVEVIVGGVRMIYPSAFVLIAQNDIPVPQTATSVGGHVTVGQQGLGNVKDPSNCGMPLTPPTSPEQVAIGESGGVQSAASHLSSQDGGMITMHSPKRSRKIPPKLHNHMVHRVWKECILNRAQAKRSQVSTPTREEEPAHNPAAWDFVDPTQRVSCSCSRHKLLKRCTIGPSRTPTVSQPGFSAGPPSSSSLPPPASSKHKTAERQEKGDKLQKRPLVPFHHRPSVAEELCMEQDASGQKLGLAGIDASLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALYGSGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYSGIRPSYTESSDKWWQGFRLPPSEDTEFRPPELQGDRFDTKLDVNPESTALQRLLAQPNKRFKIWQDEQPQVQPLPFLDPSPLSQQPGDTLGEVNDPYTFEDGDIKYIFTANKKCKQGPEKDTLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKVPAVGTEERPPGKEGRAAGPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGVNSETVTALGMMESPVVSMVPTHFSEFRMEVEDGLGSPKPEEIKDFSYVHKVPQFQPFVGSSMFAPLKTLPSHCLLPLKTPDACLFRPSWAVPPKMEQLPMPPAAASIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNVFKDRNFDSCCICACNMNIKGADVGLYIPDSSKEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSSFLPQMEGARKSPEPPISLLLLLQNQHTQPFASLSFLDYISSNSRHALPCVSWTYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHCWPHSNVLDTSMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKEFLTISPFSLPFWERLLLEPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTLAQKLTEELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSGLLMPPKHQSPPAEAQGQATPGNAGSLPSNAGSVAPPAGSAFNPTSNSSANPAASSSSASSGPSGSSTASAPGITQMNTTSSSGFSGGVGGQNPSAGGSSADRAPGNVACGDTEPGQSSTQPSQDGQDSVTDRERIGIPTEPDSADSHAYPPAVVIYMVDPFTYTAEEDSSSGNFWLLSLMRCYTEMLDHLPEHMRSSFILQIVPCQYMLQTMKDEHVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTEPGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRTLPVSVSVRSRKSKVSARKIGLQKLWEWCLGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQARNQCPLFLKASLHHHISVAQTDELLPARNSQRAPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNML
Length2217
PositionMiddle
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.07
Grand average of hydropathy-0.395
Instability index58.09
Isoelectric point5.77
Molecular weight243136.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12803
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.79|      20|      21|    1565|    1585|       1
---------------------------------------------------------------------------
 1002- 1038 (23.04/ 6.20)	PSvgsladpdylntpqmntPVTLNSTAP.ASNSGAGVL
 1549- 1583 (24.74/10.32)	PS...nagsvappagsafnPTSNSSANPaASSSSASSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.86|      26|      28|    2075|    2102|       2
---------------------------------------------------------------------------
 2075- 2102 (37.05/32.79)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2105- 2133 (44.81/28.49)	G.YFV.STAKAENLpqwFWSSCPQARNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.28|      28|      28|    1124|    1151|       3
---------------------------------------------------------------------------
 1124- 1151 (54.86/40.18)	KDRNFDSCCICACNMNIK.GADVGLYIPD
 1154- 1182 (48.42/34.45)	KEDQYRCTCGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.53|      17|      21|    1608|    1628|       4
---------------------------------------------------------------------------
 1608- 1624 (32.05/25.06)	GGVGGQNPSAGG..SSADR
 1636- 1654 (27.49/ 8.65)	PGQSSTQPSQDGqdSVTDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.02|      19|      21|     651|     669|       5
---------------------------------------------------------------------------
  651-  669 (31.40/16.74)	LQGDRFDTKLDVNPESTAL
  675-  693 (35.62/19.99)	QPNKRFKIWQDEQPQVQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.60|      16|      21|    1704|    1723|       6
---------------------------------------------------------------------------
 1713- 1734 (21.55/24.06)	PEHMrssFILQ.....ivpCQY.MLQTM
 1736- 1760 (19.06/16.85)	DEHV...FYIQylksmafsVYCqCRRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.22|      10|      30|    2026|    2039|       7
---------------------------------------------------------------------------
 2026- 2039 (15.63/14.41)	SPNNDdmfvDLPFP
 2057- 2066 (20.59/ 7.82)	SPNSS....PVPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.88|      33|     543|     430|     463|       8
---------------------------------------------------------------------------
  430-  463 (57.67/25.70)	LLKRCTIgPSRTPTVS..QPGFSAGPPSSSSLP.PPA
  956-  990 (55.05/20.83)	LPSHCLL.PLKTPDAClfRPSW.AVPPKMEQLPmPPA
 1082- 1106 (36.15/10.98)	........PASTPSTT..RPLNSVEPATMQPI..PEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.72|      42|     547|     695|     744|       9
---------------------------------------------------------------------------
  703-  744 (71.74/49.49)	QQPGDTLGEVNDPYTFEDGDIKYIFTANKKCKQGPEKDTLKK
  841-  882 (74.98/37.01)	ERPPGKEGRAAGPYPPTVADLQRMFPTPPSLEQHPAFSPVMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.83|      16|      16|    1224|    1239|      12
---------------------------------------------------------------------------
 1224- 1239 (27.34/19.67)	SLLLLL..QNQHTQPFAS
 1241- 1258 (24.49/16.60)	SFLDYIssNSRHALPCVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1266|     156|     189|      15
---------------------------------------------------------------------------
  156-  189 (52.23/44.17)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1425- 1456 (59.04/40.00)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.19|      12|      23|     543|     554|      16
---------------------------------------------------------------------------
  543-  554 (25.15/10.57)	NPMDSPHSPISP
  569-  580 (23.04/ 8.97)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.77|      11|      16|     603|     614|      20
---------------------------------------------------------------------------
  603-  614 (15.91/11.63)	GQRlPLMAEVSE
  620-  630 (20.86/10.58)	GIR.PSYTESSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12803 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CTIGPSRTPTVSQPGFSAGPPSSSSLPPPASSKHKTAERQEKGDKLQKRPLVPFHHRPSVAEELCMEQDASGQKLGLAGIDASLEV
2) FKIWQDEQPQVQPLPFLDPSPLSQQPGDTLGEVNDP
3) FRLPPSEDTEFRPPELQGDRFDTKLDVNPESTALQR
4) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) KMEQLPMPPAAASIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
6) KQGPEKDTLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKVPAVGTEERPPGKEGRAAGPYPPTVADLQRMFPTPPSLEQHPAFSPVMNY
7) SGLLMPPKHQSPPAEAQGQATPGNAGSLPSNAGSVAPPAGSAFNPTSNSSANPAASSSSASSGPSGSSTASAPGITQMNTTSSSGFSGGVGGQNPSAGGSSADRAPGNVACGDTEPGQSSTQPSQDGQDSVTDRERIGIPTEPDSA
8) SSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALY
9) TATSVGGHVTVGQQGLGNVKDPSNCGMPLTPPTSPEQVAIGESGGVQSAASHLSSQDGGMITMHSPKRSRKIPPKLH
434
680
636
2047
981
734
1521
521
297
519
715
671
2095
1101
883
1666
583
373










Molecular Recognition Features






MoRF SequenceStartStop




1) KRFKIWQ
678
684