<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12801

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASASDPMNALQSLTGGPTPGTAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQHLQQQQQHLIKLHHQSQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQAPQLPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIMSPVVCSRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGAVHLICKLDDKDLPSVPPLEISVPADYPAQSPMWIDHQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length700
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.04
Grand average of hydropathy-0.719
Instability index90.90
Isoelectric point9.20
Molecular weight77265.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12801
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     310.30|      60|      61|     142|     201|       1
---------------------------------------------------------------------------
  176-  238 (79.70/13.53)	ALQQQQQQQQQQQQQ....QFQA....QQNAM....QQ......................qfqAVVQ....QQHLQQQQqhlIKL.........HHQSQQQ.iQQQQL...QRM
  239-  301 (98.30/18.39)	AQLQLQQQQQQQQQQ....ALQAqppmQQPPM....QQ.......................ppPPPSQALPQ...QLQQ...MHH.........PQHHQPP..PQAQQ...SPV
  302-  376 (77.99/13.08)	AQNQAPQLPPQSQSQplvsQAQA....LPGPMlyaaQQ...............qlkfvsqsslTMLSSPSPGQQVQTPQ...SMP.........PPPQPSP..QPGSQ......
  435-  532 (54.32/ 6.89)	GSSQAEEQQYLDKLK....QLSK....YIEPL....RRminkidknedrkkdlskmkslldilTDPSKRCPLKTLQKCE...IALeklkndmavPTPPPPPvlPTKQQdlcQP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.50|      25|      26|     100|     124|       2
---------------------------------------------------------------------------
   81-   94 (22.34/ 9.01)	...PMNALQSLT..........GGPTP
  100-  124 (53.56/34.38)	GMPPRGPGQSLGGMG..GLGAMGQPMP
  127-  149 (36.60/20.60)	GQPP..PGTS..GMAphGMAVVSTATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.39|      16|      19|     389|     405|       3
---------------------------------------------------------------------------
  389-  405 (29.94/14.33)	PSSFlPSPSPQPSQSPV
  410-  425 (31.45/11.82)	PQNF.SVPSPGPLNTPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.20|      18|      22|     594|     611|       4
---------------------------------------------------------------------------
  594-  611 (32.82/17.26)	VARLDPKFLVNLDPSHCS
  619-  636 (32.38/16.94)	ICKLDDKDLPSVPPLEIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     658|     668|       6
---------------------------------------------------------------------------
  658-  668 (23.12/14.35)	NPFLQSVHR.CM
  686-  697 (18.67/10.21)	NTWAQSIHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.60|      10|      22|     536|     545|       7
---------------------------------------------------------------------------
  536-  545 (17.81/ 9.13)	AVLA....NIRSPV
  557-  570 (14.79/ 6.40)	AMMAihgpPIMSPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12801 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASASDPMNALQSLTGGPTPGTAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
2) QQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQAPQLPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
70
248
148
450










Molecular Recognition Features






MoRF SequenceStartStop




NANANA