<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12799

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLISEEHLHMAQSSPAPFQVLVSPYGLNGTLTGHAYKMSDPATRKLIEEWQYFYPMVLRKKEESREEAELGYDDDFPVAVEVIVGGVRMIYPSAFVLIAQNDIPVPQTATSVGGHVTVGQQGLGNVKDPSNCGMPLTPPTSPEQVAIGESGGVQSAASHLSSQDGGMITMHSPKRSRKIPPKLHNHMVHRVWKECILNRAQAKRSQVSTPTREEEPAHNPAAWDFVDPTQRVSCSCSRHKLLKRCTIGPSRTPTVSQPGFSAGPPSSSSLPPPASSKHKTAERQEKGDKLQKRPLVPFHHRPSVAEELCMEQDASGQKLGLAGIDASLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALYGSGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYSGIRPSYTESSDKWWQGFRLPPSEDTEFRPPELQGDRFDTKLDVNPESTALQRLLAQPNKRFKIWQDEQPQVQPLPFLDPSPLSQQPGDTLGEVNDPYTFEDGDIKYIFTANKKCKQGPEKDTLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKVPAVGTEERPPGKEGRAAGPYPPIADLQRMFPTPPSLEQHPAFSPVMNYKDGVNSETVTALGMMESPVVSMVPTHFSEFRMEVEDGLGSPKPEEIKDFSYVHKVPQFQPFVGSSMFAPLKTLPSHCLLPLKTPDACLFRPSWAVPPKMEQLPMPPAAASIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNVFKDRNFDSCCICACNMNIKGADVGLYIPDSSKEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSSFLPQMEGARKSPEPPISLLLLLQNQHTQPFASLSFLDYISSNSRHALPCVSWTYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHCWPHSNVLDTSMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKEFLTISPFSLPFWERLLLEPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTLAQKLTEELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSGLLMPPKHQSPPAEAQGQATPGNAGSLPSNAGSVAPPAGSAFNPTSNSSANPAASSSSASSGPSGSSTASAPGITQMNTTSSSGFSGGVGGQNPSAGGSSADRAPGNVACGDTEPGQSSTQPSQDGQDSVTDRERIGIPTEPDSADSHAYPPAVVIYMVDPFTYTAEEDSSSGNFWLLSLMRCYTEMLDHLPEHMRSSFILQIVPCQYMLQTMKDEHVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTEPGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRTLPVSVSVRSRKSKVSARKIGLQKLWEWCLGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQARNQCPLFLKASLHHHISVAQTDELLPARNSQRAPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNML
Length2216
PositionMiddle
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.07
Grand average of hydropathy-0.395
Instability index58.11
Isoelectric point5.77
Molecular weight243049.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12799
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.86|      26|      28|    2074|    2101|       1
---------------------------------------------------------------------------
 2074- 2101 (37.05/32.13)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2104- 2132 (44.81/27.92)	G.YFV.STAKAENLpqwFWSSCPQARNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.78|      16|      16|     623|     638|       2
---------------------------------------------------------------------------
  623-  638 (33.11/19.40)	PSY.TESSDKWWQGFRL
  640-  656 (25.68/13.12)	PSEdTEFRPPELQGDRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.85|      22|      25|    1014|    1035|       5
---------------------------------------------------------------------------
 1014- 1028 (21.23/ 6.15)	...........................TPQMNTPVTLNSTAP
 1029- 1056 (33.67/14.31)	ASNSGAG..............vlpspaTPRFSVPTPRTPRTP
 1057- 1096 (24.95/ 8.59)	RTPRGGGtasgqgsvkydstdqgspasTPSTTRP..LNSVEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.56|      31|     109|     432|     462|       6
---------------------------------------------------------------------------
  432-  462 (60.34/31.04)	KRCTIGPSRTP..TVS..QPGFSAGP..PSSSSLPPP
  538-  574 (43.11/19.53)	KQMNLNPMDSPhsPISplPPTLSPQPrgQEAESLDPP
 1582- 1603 (26.11/ 8.18)	.....GPSGSS..TAS..APGITQMN..TTSSS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.76|      34|     546|     684|     744|       7
---------------------------------------------------------------------------
  703-  737 (56.91/41.10)	QQPGDTLGEVNDPYTfEDGDIKYIFTANKKCKQGP
  841-  874 (62.85/17.78)	ERPPGKEGRAAGPYP.PIADLQRMFPTPPSLEQHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.83|      16|      16|    1223|    1238|       8
---------------------------------------------------------------------------
 1223- 1238 (27.34/20.17)	SLLLLL..QNQHTQPFAS
 1240- 1257 (24.49/17.03)	SFLDYIssNSRHALPCVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.89|      24|     634|     242|     302|       9
---------------------------------------------------------------------------
  242-  265 (44.22/68.15)	FYPMVLRKKEESREEAE........LGYDDDF
 1361- 1392 (38.68/ 6.09)	FHKMAGRGTYGSEESPEplpiptllVGYDKEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.33|      19|      28|     363|     381|      10
---------------------------------------------------------------------------
  363-  381 (36.57/28.63)	KRSRKIPPKLHNHMVHR..VW
  392-  412 (29.76/21.43)	KRSQVSTPTREEEPAHNpaAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.28|      28|      28|    1123|    1150|      11
---------------------------------------------------------------------------
 1123- 1150 (54.86/39.48)	KDRNFDSCCICACNMNIK.GADVGLYIPD
 1153- 1181 (48.42/33.85)	KEDQYRCTCGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1265|     156|     189|      12
---------------------------------------------------------------------------
  156-  189 (52.23/40.95)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1424- 1455 (59.04/37.06)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.84|      18|      26|    1691|    1716|      13
---------------------------------------------------------------------------
 1696- 1714 (32.24/36.54)	WLLSLMRCYTeMLDHL.PEH
 1719- 1737 (29.60/ 7.92)	FILQIVPCQY.MLQTMkDEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.54|      16|      16|    1607|    1622|      14
---------------------------------------------------------------------------
  340-  353 (22.84/ 9.34)	GGV..QSAASHLSSQD
 1607- 1622 (31.82/16.38)	GGVGGQNPSAGGSSAD
 1626- 1639 (18.89/ 6.24)	GNVACGDTEPGQSS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|      28|    2025|    2047|      19
---------------------------------------------------------------------------
 2025- 2047 (25.52/26.32)	SPNNDdmfvDLPFPDDmDNDIGI
 2056- 2073 (34.86/17.79)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.17|       8|      17|    1640|    1649|      22
---------------------------------------------------------------------------
 1640- 1649 (11.77/11.49)	TQPsqDGQDS
 1660- 1667 (15.41/ 6.77)	TEP..DSADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.52|      20|      23|      65|      84|      23
---------------------------------------------------------------------------
   65-   84 (38.38/25.79)	QANLLCVWRRDVKPDCKELW
   91-  110 (35.14/22.94)	EPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12799 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CTIGPSRTPTVSQPGFSAGPPSSSSLPPPASSKHKTAERQEKGDKLQKRPLVPFHHRPSVAEELCMEQDASGQKLGLAGIDASLEV
2) FKIWQDEQPQVQPLPFLDPSPLSQQPGDTLGEVNDP
3) FRLPPSEDTEFRPPELQGDRFDTKLDVNPESTALQR
4) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) KMEQLPMPPAAASIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
6) KQGPEKDTLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSGSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKVPAVGTEERPPGKEGRAAGPYPPIADLQRMFPTPPSLEQHPAFSPVMNY
7) SGLLMPPKHQSPPAEAQGQATPGNAGSLPSNAGSVAPPAGSAFNPTSNSSANPAASSSSASSGPSGSSTASAPGITQMNTTSSSGFSGGVGGQNPSAGGSSADRAPGNVACGDTEPGQSSTQPSQDGQDSVTDRERIGIPTEPDSA
8) SSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESLDPPSVPVNPALY
9) TATSVGGHVTVGQQGLGNVKDPSNCGMPLTPPTSPEQVAIGESGGVQSAASHLSSQDGGMITMHSPKRSRKIPPKLH
434
680
636
2046
980
734
1520
521
297
519
715
671
2094
1100
882
1665
583
373










Molecular Recognition Features






MoRF SequenceStartStop




1) KRFKIWQ
678
684