<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12792

Description cyclin-dependent kinase 19 isoform X3
SequenceMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPTAPPQQTAAPPQAPPPQQSGAQTNGTSGGAAAAAAGAGAGLQHSQDSSLNQVPPNKKPRMGPSGASSGGPVVPTDYQHSSSRLNYQSSVQGSSQSQSTLGYASSQQSTQYHPSHQTHRY
Length328
PositionKinase
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.09
Grand average of hydropathy-0.763
Instability index63.29
Isoelectric point6.59
Molecular weight36470.30
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12792
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.66|      17|      17|     200|     216|       1
---------------------------------------------------------------------------
  200-  216 (34.94/16.87)	PQQQNPHQQPTAPPQQT
  219-  235 (33.73/16.01)	PPQAPPPQQSGAQTNGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.74|      26|      32|     256|     286|       2
---------------------------------------------------------------------------
  256-  286 (41.12/27.80)	SSLN.....QVPPNKKPRMGPSGASSGgpvvpTDYQ
  290-  320 (38.62/16.56)	SRLNyqssvQGSSQSQSTLGYASSQQS.....TQYH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.52|      16|      17|     146|     161|       3
---------------------------------------------------------------------------
  146-  161 (28.65/15.70)	DPTKRITSEQALQDPY
  165-  180 (30.88/17.40)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12792 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQPQQQNPHQQPTAPPQQTAAPPQAPPPQQSGAQTNGTSGGAAAAAAGAGAGLQHSQDSSLNQVPPNKKPRMGPSGASSGGPVVPTDYQHSSSRLNYQSSVQGSSQSQSTLGYASSQQSTQYHPSHQTHRY
180
328










Molecular Recognition Features






MoRF SequenceStartStop




1) LNYQS
2) NKKPRMG
292
264
296
270