<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12790

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASASDPMNALQSLTGGPTPGTAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQHLQQQQQHLIKLHHQSQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQAPQLPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQQQAAVQTAQAAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSVCVGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIMSPVVCSRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGAVHLICKLDDKDLPSVPPLEISVPADYPAQSPMWIDHQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length757
PositionTail
OrganismMesocricetus auratus (Golden hamster)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus.
Aromaticity0.03
Grand average of hydropathy-0.653
Instability index88.17
Isoelectric point9.42
Molecular weight82886.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12790
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.44|      16|      17|     187|     203|       2
---------------------------------------------------------------------------
  187-  203 (26.85/ 6.29)	QQQQQHLiKLHHQSQQQ
  223-  238 (31.59/ 6.20)	QQQQQAL.QAQPPMQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     237.36|      43|      44|     392|     434|       3
---------------------------------------------------------------------------
  242-  281 (58.67/14.39)	QPPPPPS..Q......ALPQQLQQMHHPQ.............HHQPPPQ...AQQSPVAQnqaP
  392-  434 (83.80/24.44)	QPTAQVS..QSSLTMLSSPSPGQQVQTPQ.............SMPPPPQ...PSPQPGSQ...P
  443-  481 (53.92/12.49)	AP....S..PSSF..LPSPSP.QPSQSPV.............TARTPQNfsvPSPGPLNT...P
  527-  584 (40.97/ 7.31)	DRKKDLSkmKSLLDILTDPSKRCPLKTLQkceialeklkndmAVPTPPP...PPVLPTKQ...Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.05|      16|      26|      74|      98|       4
---------------------------------------------------------------------------
   57-   77 (25.16/ 7.19)	NALQSLT........GGPTPgtagiGMPP
   79-  104 (23.90/15.92)	GPGQSLGgmgglgamGQPMP...lsGQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.02|      17|      36|     169|     185|       6
---------------------------------------------------------------------------
  169-  185 (31.97/ 7.94)	QQNAMQQQFQAVVQQQH
  205-  221 (29.05/ 6.52)	QQQQLQRMAQLQLQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.79|      11|      27|     715|     725|       7
---------------------------------------------------------------------------
  715-  725 (23.12/12.83)	NPFLQSVHR.CM
  743-  754 (18.67/ 9.07)	NTWAQSIHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.20|      18|      27|     651|     668|       8
---------------------------------------------------------------------------
  651-  668 (32.82/20.58)	VARLDPKFLVNLDPSHCS
  676-  693 (32.38/20.19)	ICKLDDKDLPSVPPLEIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.82|      14|      27|     589|     602|       9
---------------------------------------------------------------------------
  589-  602 (24.17/15.89)	PLLDAVLA....NIRSPV
  610-  627 (21.65/13.37)	TFVPAMMAihgpPIMSPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12790 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHNKKSQASASDPMNALQSLTGGPTPGTAGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
2) QPQVQPQVQQVQPQVQQQAAVQTAQAAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSVCVGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQAPQLPPQSQSQPLVSQAQALPG
43
322
222
122
507
301










Molecular Recognition Features






MoRF SequenceStartStop




NANANA