Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNATPLDKILHGSVGYLTPRSGGHLMNIKYYASPSDLLDDKTASPIILHEKNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSVTSANSVDLPACFFLKFPKPIPVSKTFVQKLQNCTGIPLFETPPTYVPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGQSLQGTLVSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTVLKEDTPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMATGNNPMSGTTTPTNTFPGGPITTLFNMSMSIRDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRVPPDKSKHQTEDDFQRELFSMDVDSQNPMFDVSMTADALDTPHITPAPSQCSTPPTTYPQTVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTNDDCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKSSGQADTVDFSIISVAGKALGPADIMEHHSGSQSPLMATGELGKEKTQKRVKEGNGTGGGSGSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSHSQYSSSGSVSSSGSKSHHSHSSSSSSSSSASTSGKMKSSKSEGSSSSKLSGSMYSSQGSSGSSQSKNSSQTGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPCLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSSGPHMSGTSSSSGIKSSSGSGSSGSLSQKTPPASNSCTPSSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDSQMGVSTNSSSHPMSSKHNMSGGEFQSKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQIASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNVDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQTLSMTNNPILSADRPSRLSPDFMMGEEDDDLMDVALIGN |
Length | 1531 |
Position | Middle |
Organism | Mesocricetus auratus (Golden hamster) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Mesocricetus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.674 |
Instability index | 53.15 |
Isoelectric point | 8.81 |
Molecular weight | 162378.32 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP12787 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 11| 888.32| 99| 100| 1059| 1157| 1 --------------------------------------------------------------------------- 547- 603 (46.29/ 6.43) ......................SKV..........................SQNPIL........TS......LLQ..ITG..NGGSTIG..SSPT...PPHH...TPPPVSSMAGN.....TK.NHP..........................MLMN..LLKDN........................... 605- 701 (52.53/ 8.31) .....................AQDFS.....................TLY...GSS.........PL......ERQ..NSS....SGSP...........RME...MCSGSNKTKKKkssrvPP.DKSKhqteddfqrelfsmdvdsqnpmfdvSMTADALDTPHI...TPAP.S...QcstPP.......T 713- 815 (70.65/13.78) SIQRMVRLSSSD..SIGP..DVTDILsdiaeeasklpstnddcppiGTPVRDSSSSG........HS......QSAlfDSDvfQTNN...........................NEN.....PY.TDPA.........................DLIADAAGSPSS..dSPTN.H...F...FPDGVD.... 816- 909 (55.25/ 9.14) ........................FN....................PDLLNSQSQSGfgeeyfdeSS......QSG..DND..DFKG.FA..SQAL...NTLGvpmLGGDNGETKFK.....SS.GQAD..................tvdfsiiSVAGKALGPADI...MEHH.S..........GSQSplM 910- 981 (68.15/13.03) ATGELGKEKTQKrvKEGN..GT........................G......GGSG........SG......PGL..DS.......KPG..K..............RSRTPSNDGK.....SK.DKP..............................PKRKKADTegkSPSH.SssnR...P......... 983- 1055 (75.73/15.31) ........TPPT..STG.............................GS..KSPGSSG......................RS..QTP..PGvaTPPI...PKIT...IQIPKGTVMV.........GKPS.........................H..SQYSSSGSV...SSSG.S...K.shHSHSSSS..S 1059- 1157 (176.10/45.58) SASTSGKMKSSK..SEGS..SSSKLS....................GSMYSSQGSSG........SS......QSK..NSS..QTGGKPG..SSPI...TKHG...LSSGSSSTKMK.....PQ.GKPS.........................SLMNPCLSKPNI...SPSH.S...R...PPGGSDK..L 1161- 1224 (86.29/18.49) MKPVPGTPPSSK..AKSP..IS.............................S.GSSG........PH......MSG..TSS..SSGIKSS..SGS.......G....SSGSLSQK..........TPPA.........................S..NSC.........TPSS.S...S............. 1226- 1296 (66.43/12.51) ................SS..SGS........................SMSSSQNQHG........SS......KGK..SPS..R.NKKPS..LTAVidkLKHG..vVTSG............PG.GE..............................DPMDSQMGV...STNS.S...S...HPMSSKH... 1298- 1388 (89.59/19.49) ...MSGGEFQSK..REKSdkDKSKVS....................TSGGSVDSSKK........TS......ESK..NVG..STG..VA..KIII...SKH.....DGGSPSIKAK.....VTlQKPG.........................ESSGEGL.RPQI...ASSK.N...Y......GSPL..I 1389- 1492 (101.31/23.03) SGSTPKHERGSP..SH.S..KSPAYT....................PQNVDSESESG........SSiaeksyQNS..PSS..DDGIRPL..PEYS...TEKH...KKHKKEKKKVK.....DR.DRDR.........................DKDRDKKKSHSI...KPENwS...K...SPISSDQ... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 101.83| 31| 48| 103| 134| 2 --------------------------------------------------------------------------- 103- 134 (49.82/34.91) KHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD 153- 185 (52.01/32.06) KILHGSVG.YLTPrsGGHLMNIKYYASPSDLLDD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 300.52| 84| 164| 189| 276| 3 --------------------------------------------------------------------------- 189- 275 (142.24/92.03) SPIIL.HEKNVPRSLGM...............NASVTIEGTSAMYKLPIAPL......IMGSHPVDNKWTPSFSSVTSANSVdlpACFFL.K.FPKPIPVSKT..FVQK.L...QNC 277- 324 (44.77/33.38) .............................................GIP..........LFETPPT...YVPLYELIT.........QFELsK.DPDPLPLNHNmrFYAA.LpgqQHC 345- 452 (113.51/65.04) SKITFqHPGRVPLILNMirhqvayntligscvKRTVLKEDTPGLLQFEVCPLsesrfsVSFQHPVNDSLVCVVMDVQDSTHV...SCKLY.KgLSDALICTDD..FIAKvV...QRC --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 59.45| 17| 20| 492| 509| 4 --------------------------------------------------------------------------- 492- 509 (28.30/18.80) PPASSPGYGMATGNNpMS 514- 530 (31.14/15.82) PTNTFPGGPITTLFN.MS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYFD 2) IKAKVTLQ 3) IPKITIQIPK 4) IRPLPEYSTEKHKKHKKEKKKVK 5) KPSLTAVIDKLKHGV 6) LRPQIA 7) RLSPDFMMGEEDDDLMDV 8) VAKIIISKH | 829 1356 1011 1438 1252 1373 1509 1341 | 835 1363 1020 1460 1266 1378 1526 1349 |
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