<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12763

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSTLVRRAAEESFLSLKDLVEKSKSSEQSDSEKKISLLKYIVKTRQRMLRLNVLAKWCQQVPLVQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVLLTGNYQRLPKCVEDMGIQSTLTEDQQQPALKKLDTLVRSKLLEVTLLKEVSEIKVTDGTALLRVNGEFKVLLTLGYRGHLSLWRILHLELLVGERNGPVKLEESRRHALGDDLERRMSVAENPFMILYSILHELCVALIMDTVIRQVQAMRQGRWKEAIRFELISDGSTGQGGSGGSMQMTQDGEADSAGLKTPGVKIVYWLDIDKNTGGSDSGSCPFIKIEPVQDLQIKCLHNTFVIDPLTGKEAKLSLDQSCIDVEKLLLRAICCNRYTRLLEIHKELSRNGHICQAAGDVVLHCYSDESDADLKKRENKSSVREYGGNEVLRVRAYGSSYITLGINIRNGRFLLQSSRNILTPSALSDCEEALNQGSMSAAEVFASLRSKSILHLFESIGRFLGLKVYEQGLAAVKIPKTILNGSSLLLMGFPQCGSSYFLLMQLDKDFKPLFKLLETQPDPSGKSHTASDSSHVIRFNKIDIGQLQILEDEFNSSLLDWDRILSSLPNAVGPNQSSEHGLLSEFGLETSVQSSGCPHPSFSSVVDEVFELEKGALSPPFPVNNHLSSSFNASPFLGSLPMNHQGMKSGISSPKWEGGSQFSQINNVTKSTISGAHFNSPLYPSNNLKGIVQSSSVSSLSSSPVRSPSIQKLSTSKSDHDLTSLRSPHSVEISSSSMDDDQVKFLNESSKDVSGGRTSRLSSPLRPTGSRASAPNMKSNGLRNSPTGQIGVSVRASGSNMWTATPVSQAPEPGISQSTSYDIMPKHDRNPRKRTISDIVKLIPSVQGVEASTGSSKRRKTSESSGNHPPQVLYSSDFISRTEGYTYGNLLAEANKGNAPSNIYVIALLHVVRHCSLCIKHARLTSQMDALDIPYVEEVGLRTPSSNLWFRLPFARDDSWQHICLRLGRPGSMYWDVKINDRHFRDLWELQKGSNTTPWGSGVRIANTSDIDSHIRYDPEGVVLSYRSVEADSIKKLVADLRRLSNARSFALGMRKLLGVRPEDKLEENCANAENKAPVGGKGSVEVGDKVTDQMRRAFRIEAVGLMSLWFSFGPGVVARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLLSLAAATRPARAGPASGAPGVTANLSAIPKQNGFMPSQGLLPGGSSSNATQATSTTVGNPVASTGMGPLGSHSFHSVATLAVAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFAVDMRCFAGDQVWLQPATPPKGGPSFGGSLPCPQFRPFIMEHVAQELNGLEPNFSGGQQPVGLVNSSNLNPGSGAQLSAAGGSRVNLTASSPISRSTPMAGNQVAGLSRMGNALLTQNLAAVGSGLPLRRTPGTGVPVHVRGELNTAFIGLGDDGGYGGGWVPVVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNQANAQEELTQAEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKVIAWKKGLSQAQGGDIAPAQKPRIELCLENHAGSTMEENPKHSSTSKSNIHYDRPHNSVDFGLTVVLDPVHIPHINAAGGAAWLPYCVSVRLRYSFGENPHVSFLGMEGSHGGRACWLRLEDWEKCKQRVARTVELSATSAGDVAQGRLRVVADNVQRTLQGCLQGLRDGGGITGSSGAT
Length1831
PositionTail
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.06
Grand average of hydropathy-0.229
Instability index47.62
Isoelectric point8.53
Molecular weight199226.20
Publications
PubMed=23663246

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP12763
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     953.91|     298|     318|     637|     953|       1
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  642-  961 (463.82/352.24)	LETSVQSSGC.PH.......PSFSSVVD..EVFELEKGALSPPFPVNNHLSSSFNAS...PFLGSLPMNH.....QGMKSG.ISSPKWE...GGSQ.FSQINNVTKSTISGAHFNSPLYPSN..NLKGIVQ.SSSVSSLSSSPVRSPSIQKLSTsksdhDLTSLRSPHSVEISSSSM....DDDQVK..FLNESSKDVSGGRTSrLSSPLRPTGSRASAPNMKSNGLRnSPTGQIGVSVRASGSNMWtatpvsQAPEPGISQSTSYDIMPKHDRNPRK....RTISDIVKLIPSVQGVEASTGSSKR.RKTSESSGnhPPQVLYSSDFISRTEGY..TYGnLLAEANKGNA........................................psniyvIA
  963- 1322 (409.99/263.54)	LHVVRHCSLCiKH.......ARLTSQMDalDIPYVEEVGLRTP...SSNLWFRL......PFARDDSWQH.....ICLRLGrPGSMYWDvkiNDRH.FRDLWELQKGS.NTTPWGSGVRIANtsDIDSHIRyDPEGVVLSYRSVEADSIKKLVA.....DLRRLSNARSFALGMRKLlgvrPEDKLEenCANAENKAPVGGKGS.VEVGDKVTDQMRRAFRIEAVGLM.SLWFSFGPGVVARFVVEW......ESGKEGCTMHVSPDQLWPHTKFLEDfingAEVSSLLDCIRLTAGPLLSLAAATRpARAGPASG..APGVTANLSAIPKQNGFmpSQG.LLPGGSSSNAtqatsttvgnpvastgmgplgshsfhsvatlavagrggpgivpsslLP
 1323- 1451 (80.10/36.55)	IDVSVVLRG..PYwiriiyrKNFA..VD.mRCFAGDQVWLQPATPPKG..GPSFGGSlpcPQFRPFIMEHvaqelNGLE......PNFS...GGQQpVGLVNSSNLNPGSGAQLSAAGGSRV..NL...TA.SSPIS..RSTPMAGNQVAGLS......................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     351.94|     118|    1363|      91|     217|       2
---------------------------------------------------------------------------
   91-  217 (180.07/147.03)	FTQaadSLFFMHEGLQQARAPIYDVPSAIEVLLTGNYQRLPkcvEDMG.....IQSTLTEDQQQPALKKLDTL.VRSKLLEvtLLKEV..SEIKVTDGtALLRVNGEFKVL..LTLGYRGHLSLWRI.LHLELLVGER
 1458- 1586 (171.87/115.35)	LTQ...NLAAVGSGLPLRRTPGTGVPVHVRGELNTAFIGLG...DDGGygggwVPVVALKKVLRGILKYLGVLwLFAQLPD..LLKEIlgSILKDNEG.ALLNLDQEQPALrfFVGGYVFAVSVHRVqLLLQVLSVKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.59|      28|     996|     290|     318|       3
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  290-  318 (46.30/24.28)	STGQgGSGGSMQMTQDGEADSAGLKTPGV
 1288- 1315 (51.29/23.33)	STGM.GPLGSHSFHSVATLAVAGRGGPGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.74|      26|     248|     218|     243|       4
---------------------------------------------------------------------------
  218-  243 (46.77/26.59)	NGPVKLEESRR....HALGDDLER....RMSVAE
  464-  497 (34.97/18.03)	NGRFLLQSSRNiltpSALSDCEEAlnqgSMSAAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12763 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QSSSVSSLSSSPVRSPSIQKLSTSKSDHDLTSLRSPHSVEISSSSMDDDQVKFLNESSKDVSGGRTSRLSSPLRPTGSRASAPNMKSNGLRNSPTGQIGVSVRASGSNMWTATPVSQAPEPGISQSTSYDIMPKHDRNPRKRTISDI
747
893










Molecular Recognition Features






MoRF SequenceStartStop




NANANA