<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12738

Description mediator of RNA polymerase II transcription subunit 12-like isoform X2
SequenceMQRYSATSCGGVSSTAVGGASARDSARADPSFSSSNFSLNTRRPLQLNPYKLKCDKEPLNCRLGPPDFYPQSPNCPEETLTREYVQSGYKETIEGLEEARELILSQLTTFTKPVIIKCKEAIRKRLRAINDSRAQKRKAGQVYGVPLSGSLLLKPGVFPEQRACGEDSRKKWIEGLSQQHKRLRALADHVPHGFRRKALFEVLIRHNVPLLRATWFIKVTYLNQVRPVSANVSSGATDKTQLNRSDLWTKDIIEYLQYLLDEYISKDGSLGRDQSPQMLLAGSVHKGDSTPTLTDDEEPSLHFKWWYMVRILQWHHAEGLVLPSHIIEWVLSQLQDKESLETLQLLLPIIYAMIETIVLSQTYVRNLVEVAVRSIQEPSSGGSDLVDNSRRAYTASAVIEMLRYLIVAVPDTFVALECFPLAPSVISGVTNGRSFFSKASEDSEKTHYGPGELITMYGDRRQDAHNQFLSFDYLVSSIQKRADNLGKAVSPGLQGHGVAKAVQALDKALTLGDLRGAYNFLFENLCDGNIEEVWIAEVSPCLYSSMKWMGMVSFSFICSLFFLFEWATCDFRDCRTSLPLDLKFTGRKDFSQVYIAVLLLKMKMEDMCNSIQSKNGSTLGAGIFSGGTTGENVFVSKNKSKSLGGRIDSSDIFQSPGPVHDIIVCWIDQHDVGKGEGFKRLQLLIIELIRSGIFYPPAYVRQLIVSGIMDRSETLVDLDRRKRHYHVLKQLPGAYMLDSLEEAQIADVPVLEEALHVYANERRLLLLGLLGDHTSHSKNGNDVSFFSPKQKDNPSSGRNAASPSLEHLKNLRSASNPLSGRDAKMKVQVSEVKAAISMLLHLPSSYSAASDTRSDESQWSCKRSIGPISNKMDVTEGTPGCEECRRSKKQKLSEDRSSYTHGFLQNPSDDEDSWWVRKGPKSMESFKVDPPLKSTKHASRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNKISCPHHRTGTEGDVSKPSDGMRTAHLGDVVSIGKALKQLRLLEKRAITVWLITSVRQLIEGFEKSISKVGQCTGPLPSSIDDKNSVRWKLTEDELSAILYLMDISFDLVSAVKFLLWLLPKIPSTTNSNIHSGRSILMLPKNTECYSCEVGEAFLLSSIRRYENIIVAADLLHETLSATMHRAATVMTTNGRASGSAAFVYARNLLKKYCNVPSVAKWEKNFRATSDQRLLAELESGRALDGEFGFPLAVPAGVEDLDDYFRQKISGRLSRPTPGMKEIVQKHIDEAMHYFYSKERKLFTAGAPKGPSLEKCDDGYQMAQQIVLGLMECIRQNNNAPQEVDPFVVASAVSAIVGNVVSALVKMPDFTTSSNYPNFPSPINSLNCARRIVHIHIACLCLLKEALGERQSRVFEIALATEASSAVATALAPGKGSRSQFQLSPEAHDSNSSLSNEMLNTAKVFLGRATKAAAAVSSLVVGAVVHGAASLERMISVLRLKEGLDIIQFVRSARTSSNGISRSIGALKVDNLIEVYLHWFRLLVGNCRMVSDGLVVELLGEPYILALSRMQRMLPLSLVLPPAYSIFALVIWRPYILNSNIVIREDVQLHQSLASTINDVIRHQPFRDVCLRDTHAFYDILASDVGDSEFAAMLEMHGTDKHMKTMAFVPLRARLFLNAILDCKLPHSMSSHDDGTRVSGHGELKVQRAESETKLQDQLLHVLDTLQPAKFHWQWVELRFLLNEQALIEKIDTHNMSLAEAIRSLSPSADNSVLSENESNFNEIILTRLLVRPDASPLYSEVVHLLGKSLEESLLLQTKWFLGGNDVLFGRKSIRQRLVNIAQIRGLSTKIQFWKPWGWPHSAADLAVIRGEKKKFEVASLEEGEVVEEGVDFKRSGRLTSQTFDSEGFNCGQQYATERSLVELVLPCIDRSSSESRNAFASDLIKQMNGIEQQINAVTRGTGKQAGAVPSGIEGGTNKGSSRKGIRGGSPGLGRRSTGPTDSALPSSAALRASMWLRLKLLLRLFPLIYADRNMRLLLSSAILRLLGSRVVHEDADLSYPTQRSSPSKREVESPIEPSAVISLDLCGDSLFDWLLAMLHGLLSSCKPSWLKPKSVSKSTVKSPRDISVFDREAVESLQNELDRMQLPESIRWRLQAAMPILPPCSSFSISCQMPAVSTAALALLQSSFSVPMFQHGTSNLPQKNQVPSARTPASIPGKSKPLPSQDQDMEIDPWTLLEDGTSSGPSSNNCSLGATADHSNLKACSWLRGAVRVRRTDLTYIGAVDDDS
Length2260
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.227
Instability index53.98
Isoelectric point8.55
Molecular weight250200.21
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12738
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     345.74|     110|     345|     326|     442|       1
---------------------------------------------------------------------------
  209-  297 (109.92/73.42)	.......................PL.LRA...TWFIKVTYL.N....QVRPVsANVSSGATDKTQLNRSDLWTKDIIEYLQYLL....DEYISKDgslGRDQSPQmLLAGsVHKGDSTPTLTDDE
  326-  442 (169.54/138.57)	IIEWV.LSQLQDKESLETLQLLlPI.IYAMIETIVLSQTYVRNLVevAVRSI.QEPSSGGSDLVDNSRRAYTASAVIEMLRYLIvavpDTFVALE...CFPLAPS.VISG.VTNGRSFFSKASED
  663-  721 (66.29/39.69)	IVCWIdQHDVGKGEGFKRLQLL...iIELIRSGIFYPPAYVRQLI...VSGI.MDRSET...LVDLDRR........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     458.10|     146|     345|     843|    1007|       2
---------------------------------------------------------------------------
  846- 1007 (236.79/206.11)	YSAASDTRSDESQWSCKRSIGPISNKMDVtegtP.GCEECRRSKKQKLSEDRSSYTHG...FLQNPSDDEDSWWVRK........GPKSmesfkvdPPLKSTKHASRGRQKIV.......RKTQSLAQLAAARIEGSqgaSTSHVCDNKIS....CPHHRTGTE.GDVSKPSDGMRTAHlgDVVSI
 1197- 1366 (221.31/148.73)	FRATSDQRLLAELESGRALDGEFGFPLAV....PaGVEDLDDYFRQKISGRLSRPTPGmkeIVQKHIDEAMHYFYSKerklftagAPKG.......PSLEKCDDGYQMAQQIVlglmeciRQNNNAPQEVDPFVVAS...AVSAIVGNVVSalvkMPDFTTSSNyPNFPSPINSLNCAR..RIVHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.02|      43|     343|    1424|    1480|       3
---------------------------------------------------------------------------
 1424- 1480 (58.51/76.73)	SLSNEMLNTAKVFLGRATkaaaavsslvvgaVVHGAASL.ERMISVLRLKeGLDI.IQF
 1780- 1824 (65.51/50.39)	SLEESLLLQTKWFLGGND.............VLFGRKSIrQRLVNIAQIR.GLSTkIQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.69|      15|      17|     478|     492|       4
---------------------------------------------------------------------------
  459-  472 (18.47/ 9.64)	.DRRQDAHNQFLSFD
  478-  492 (24.26/15.23)	IQKRADNLGKAVSPG
  498-  512 (20.96/12.05)	VAKAVQALDKALTLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.40|      22|     208|     513|     542|       5
---------------------------------------------------------------------------
  513-  542 (29.19/41.99)	DLRGAYnflfenLCDgNIEEVWIAEVsPCL
  730-  751 (40.22/25.07)	QLPGAY......MLD.SLEEAQIADV.PVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.74|      14|      17|     772|     785|       6
---------------------------------------------------------------------------
  772-  785 (25.43/15.87)	DHTSHSKNGNDVSF
  792-  805 (24.31/14.79)	DNPSSGRNAASPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.06|      66|     989|    1065|    1135|       9
---------------------------------------------------------------------------
 1065- 1135 (100.05/81.76)	LTEDELsaILYLMDISFDLVSAVKfLLWLLPKipSTTNSNIHSGRSILMLPKNT.ECYSCEVGEAFLLSSIR
 2057- 2123 (113.02/73.90)	LCGDSL..FDWLLAMLHGLLSSCK.PSWLKPK..SVSKSTVKSPRDISVFDREAvESLQNELDRMQLPESIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      16|      17|      27|      42|      11
---------------------------------------------------------------------------
   27-   42 (27.00/16.00)	RADP.SFSSSNFSLNTR
   46-   62 (25.25/14.43)	QLNPyKLKCDKEPLNCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.45|      15|      17|      69|      85|      12
---------------------------------------------------------------------------
   69-   85 (24.97/21.23)	YPQSPNCPEEtlTREYV
   89-  103 (24.49/13.72)	YKETIEGLEE..ARELI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.72|      19|     360|    1645|    1665|      13
---------------------------------------------------------------------------
 1645- 1665 (30.81/25.60)	RLFL.NAILdcKLPHSMSSHDD
 2007- 2026 (27.91/15.07)	RLLLsSAIL..RLLGSRVVHED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.34|      36|     143|    1551|    1588|      15
---------------------------------------------------------------------------
 1551- 1588 (54.49/48.50)	LPPAYSIFALVIWRpYILNSNIVIrEDVQLH.QSLASTI
 1697- 1733 (60.85/42.68)	LQPAKFHWQWVELR.FLLNEQALI.EKIDTHnMSLAEAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12738 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESQWSCKRSIGPISNKMDVTEGTPGCEECRRSKKQKLSEDRSSYTHGFL
2) GNDVSFFSPKQKDNPSSGRNAASPSLEHLKNLRSASNPLSGRDAKMK
3) HGTSNLPQKNQVPSARTPASIPGKSKPLPSQDQDMEIDPWTLLEDG
4) TRGTGKQAGAVPSGIEGGTNKGSSRKGIRGGSPGLGRRSTGPTDSA
856
780
2167
1930
904
826
2212
1975










Molecular Recognition Features






MoRF SequenceStartStop




1) WWVRK
914
918