<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12738

Description mediator of RNA polymerase II transcription subunit 12-like isoform X2
SequenceMQRYSATSCGGVSSTAVGGASARDSARADPSFSSSNFSLNTRRPLQLNPYKLKCDKEPLNCRLGPPDFYPQSPNCPEETLTREYVQSGYKETIEGLEEARELILSQLTTFTKPVIIKCKEAIRKRLRAINDSRAQKRKAGQVYGVPLSGSLLLKPGVFPEQRACGEDSRKKWIEGLSQQHKRLRALADHVPHGFRRKALFEVLIRHNVPLLRATWFIKVTYLNQVRPVSANVSSGATDKTQLNRSDLWTKDIIEYLQYLLDEYISKDGSLGRDQSPQMLLAGSVHKGDSTPTLTDDEEPSLHFKWWYMVRILQWHHAEGLVLPSHIIEWVLSQLQDKESLETLQLLLPIIYAMIETIVLSQTYVRNLVEVAVRSIQEPSSGGSDLVDNSRRAYTASAVIEMLRYLIVAVPDTFVALECFPLAPSVISGVTNGRSFFSKASEDSEKTHYGPGELITMYGDRRQDAHNQFLSFDYLVSSIQKRADNLGKAVSPGLQGHGVAKAVQALDKALTLGDLRGAYNFLFENLCDGNIEEVWIAEVSPCLYSSMKWMGMVSFSFICSLFFLFEWATCDFRDCRTSLPLDLKFTGRKDFSQVYIAVLLLKMKMEDMCNSIQSKNGSTLGAGIFSGGTTGENVFVSKNKSKSLGGRIDSSDIFQSPGPVHDIIVCWIDQHDVGKGEGFKRLQLLIIELIRSGIFYPPAYVRQLIVSGIMDRSETLVDLDRRKRHYHVLKQLPGAYMLDSLEEAQIADVPVLEEALHVYANERRLLLLGLLGDHTSHSKNGNDVSFFSPKQKDNPSSGRNAASPSLEHLKNLRSASNPLSGRDAKMKVQVSEVKAAISMLLHLPSSYSAASDTRSDESQWSCKRSIGPISNKMDVTEGTPGCEECRRSKKQKLSEDRSSYTHGFLQNPSDDEDSWWVRKGPKSMESFKVDPPLKSTKHASRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNKISCPHHRTGTEGDVSKPSDGMRTAHLGDVVSIGKALKQLRLLEKRAITVWLITSVRQLIEGFEKSISKVGQCTGPLPSSIDDKNSVRWKLTEDELSAILYLMDISFDLVSAVKFLLWLLPKIPSTTNSNIHSGRSILMLPKNTECYSCEVGEAFLLSSIRRYENIIVAADLLHETLSATMHRAATVMTTNGRASGSAAFVYARNLLKKYCNVPSVAKWEKNFRATSDQRLLAELESGRALDGEFGFPLAVPAGVEDLDDYFRQKISGRLSRPTPGMKEIVQKHIDEAMHYFYSKERKLFTAGAPKGPSLEKCDDGYQMAQQIVLGLMECIRQNNNAPQEVDPFVVASAVSAIVGNVVSALVKMPDFTTSSNYPNFPSPINSLNCARRIVHIHIACLCLLKEALGERQSRVFEIALATEASSAVATALAPGKGSRSQFQLSPEAHDSNSSLSNEMLNTAKVFLGRATKAAAAVSSLVVGAVVHGAASLERMISVLRLKEGLDIIQFVRSARTSSNGISRSIGALKVDNLIEVYLHWFRLLVGNCRMVSDGLVVELLGEPYILALSRMQRMLPLSLVLPPAYSIFALVIWRPYILNSNIVIREDVQLHQSLASTINDVIRHQPFRDVCLRDTHAFYDILASDVGDSEFAAMLEMHGTDKHMKTMAFVPLRARLFLNAILDCKLPHSMSSHDDGTRVSGHGELKVQRAESETKLQDQLLHVLDTLQPAKFHWQWVELRFLLNEQALIEKIDTHNMSLAEAIRSLSPSADNSVLSENESNFNEIILTRLLVRPDASPLYSEVVHLLGKSLEESLLLQTKWFLGGNDVLFGRKSIRQRLVNIAQIRGLSTKIQFWKPWGWPHSAADLAVIRGEKKKFEVASLEEGEVVEEGVDFKRSGRLTSQTFDSEGFNCGQQYATERSLVELVLPCIDRSSSESRNAFASDLIKQMNGIEQQINAVTRGTGKQAGAVPSGIEGGTNKGSSRKGIRGGSPGLGRRSTGPTDSALPSSAALRASMWLRLKLLLRLFPLIYADRNMRLLLSSAILRLLGSRVVHEDADLSYPTQRSSPSKREVESPIEPSAVISLDLCGDSLFDWLLAMLHGLLSSCKPSWLKPKSVSKSTVKSPRDISVFDREAVESLQNELDRMQLPESIRWRLQAAMPILPPCSSFSISCQMPAVSTAALALLQSSFSVPMFQHGTSNLPQKNQVPSARTPASIPGKSKPLPSQDQDMEIDPWTLLEDGTSSGPSSNNCSLGATADHSNLKACSWLRGAVRVRRTDLTYIGAVDDDS
Length2260
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.227
Instability index53.98
Isoelectric point8.55
Molecular weight250200.21
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12738
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     345.74|     110|     345|     326|     442|       1
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  209-  297 (109.92/73.42)	.......................PL.LRA...TWFIKVTYL.N....QVRPVsANVSSGATDKTQLNRSDLWTKDIIEYLQYLL....DEYISKDgslGRDQSPQmLLAGsVHKGDSTPTLTDDE
  326-  442 (169.54/138.57)	IIEWV.LSQLQDKESLETLQLLlPI.IYAMIETIVLSQTYVRNLVevAVRSI.QEPSSGGSDLVDNSRRAYTASAVIEMLRYLIvavpDTFVALE...CFPLAPS.VISG.VTNGRSFFSKASED
  663-  721 (66.29/39.69)	IVCWIdQHDVGKGEGFKRLQLL...iIELIRSGIFYPPAYVRQLI...VSGI.MDRSET...LVDLDRR........................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     458.10|     146|     345|     843|    1007|       2
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  846- 1007 (236.79/206.11)	YSAASDTRSDESQWSCKRSIGPISNKMDVtegtP.GCEECRRSKKQKLSEDRSSYTHG...FLQNPSDDEDSWWVRK........GPKSmesfkvdPPLKSTKHASRGRQKIV.......RKTQSLAQLAAARIEGSqgaSTSHVCDNKIS....CPHHRTGTE.GDVSKPSDGMRTAHlgDVVSI
 1197- 1366 (221.31/148.73)	FRATSDQRLLAELESGRALDGEFGFPLAV....PaGVEDLDDYFRQKISGRLSRPTPGmkeIVQKHIDEAMHYFYSKerklftagAPKG.......PSLEKCDDGYQMAQQIVlglmeciRQNNNAPQEVDPFVVAS...AVSAIVGNVVSalvkMPDFTTSSNyPNFPSPINSLNCAR..RIVHI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.02|      43|     343|    1424|    1480|       3
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 1424- 1480 (58.51/76.73)	SLSNEMLNTAKVFLGRATkaaaavsslvvgaVVHGAASL.ERMISVLRLKeGLDI.IQF
 1780- 1824 (65.51/50.39)	SLEESLLLQTKWFLGGND.............VLFGRKSIrQRLVNIAQIR.GLSTkIQF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.69|      15|      17|     478|     492|       4
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  459-  472 (18.47/ 9.64)	.DRRQDAHNQFLSFD
  478-  492 (24.26/15.23)	IQKRADNLGKAVSPG
  498-  512 (20.96/12.05)	VAKAVQALDKALTLG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.40|      22|     208|     513|     542|       5
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  513-  542 (29.19/41.99)	DLRGAYnflfenLCDgNIEEVWIAEVsPCL
  730-  751 (40.22/25.07)	QLPGAY......MLD.SLEEAQIADV.PVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.74|      14|      17|     772|     785|       6
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  772-  785 (25.43/15.87)	DHTSHSKNGNDVSF
  792-  805 (24.31/14.79)	DNPSSGRNAASPSL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.06|      66|     989|    1065|    1135|       9
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 1065- 1135 (100.05/81.76)	LTEDELsaILYLMDISFDLVSAVKfLLWLLPKipSTTNSNIHSGRSILMLPKNT.ECYSCEVGEAFLLSSIR
 2057- 2123 (113.02/73.90)	LCGDSL..FDWLLAMLHGLLSSCK.PSWLKPK..SVSKSTVKSPRDISVFDREAvESLQNELDRMQLPESIR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      16|      17|      27|      42|      11
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   27-   42 (27.00/16.00)	RADP.SFSSSNFSLNTR
   46-   62 (25.25/14.43)	QLNPyKLKCDKEPLNCR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.45|      15|      17|      69|      85|      12
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   69-   85 (24.97/21.23)	YPQSPNCPEEtlTREYV
   89-  103 (24.49/13.72)	YKETIEGLEE..ARELI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.72|      19|     360|    1645|    1665|      13
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 1645- 1665 (30.81/25.60)	RLFL.NAILdcKLPHSMSSHDD
 2007- 2026 (27.91/15.07)	RLLLsSAIL..RLLGSRVVHED
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.34|      36|     143|    1551|    1588|      15
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 1551- 1588 (54.49/48.50)	LPPAYSIFALVIWRpYILNSNIVIrEDVQLH.QSLASTI
 1697- 1733 (60.85/42.68)	LQPAKFHWQWVELR.FLLNEQALI.EKIDTHnMSLAEAI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12738 with Med12 domain of Kingdom Viridiplantae
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