<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12733

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLQQISWFQFLPYESDLSPLPEKSVKADQKDAATLLVLSSHLQLQQEGLLSAWTNSFVGPWDPSQGMHNPDEKIKLWLFLPGRHSSVVEHAQAAVSRLRVVGTGLWLAPGDSEEVAAALSQALRNCIERSIRGLSYVRFGDVFSRCLPFLRAEKLFRRVQPTVEFVFAATEEAIFVHVIISAKHVRPLSCDDMESVLRHLSSNNTGERLPVIIAPHGMRGKLTGCCPSDLVKQVYFSKARTSNGFTVLGLPSQAVQASSCQLRGQNCHVEITLGCTGKGVALAKVGLKQGPGHHYPVLQRTFIYPAEAVLVPVMHTVFAKSSLKRIWVQNWVGTSLFGSSFFMHCLGLGSTGKMESLDGQGIDSSGIHTLHSNNSSSNSNSSSNNSISNTSSESDYRNTTRGSDLEADADSLTCRQSGLSSSDQLENDGLKLASKRPRTSMTDSFGQTGTVINETMQDPYKSEYNSIEVNNSATAGVANDQVGPLWVWDDEDRATGMDIQTLLSEFGDFGDFFENDALPFGEPPGTAESQALLFPVDGGDGSSSPCTMGIDVTDQMLLPALGFPSFEGFNQLPKDVTEEFNSKNQEIQSSGPGSNSLAPSTGESDHLSKVEAMMIFAPEYRAIEASISELPSSIFRSPYLPRSRKENSSHSSSNVYVYGARPPCSPCLDVSDGKPSIAVNSETVPGGCEANSILNLKKYYTYVETEKEKLDRGSLACNNSIISSEVVTSSCEGVAPSFSGLTSTHAVKSVQRNKNGSMFEAGNFLLSSKTVLAADIECIMFQAAMCRMRHLLLSSTNLDSSGLGKFSGGVVSTQLPGGTSTVTDKFSSRYDVKKKESIPVRIAGDVEGGMLDGPLNAPVGVWRSVGVPKGAKSASSPSIDGAPPMPHNSLNEEGTFVYGQKRPLQGLLDSMPLLVQQATSFVDVALDADYGDGPYGWLALEEQRRRGFSCGPSNIHAGCGGILASCHSLDIAGMELLDPLSANVNVASMLSLLQSDIKTALKSAFGNLDGPLSILDWCKGRSQSSDTGSVANGYLVESTSSDLKDSSSTVAVAAGEPVSPPQSSTVSSAGLKVSSATDGVRVDENFQRRSNQEICGSESDQRLRPTPTVLPLPAILVGYQDDWLKTSANSLQLWEKAPLEPYALPKPMSYYVICPDIDPLTSAAADFFQQLGTVYEACKLGNHAPQTMESQTELPSGRWLSSGFVIMDCPQTMKIESSNASFVGSISDYLLSLSNGWELTSFLKSLSKVLKSLKLSSSSTMSQKEGVADPCTVIYVVCPYPEPIAVLQTVVESSAAIGSIIHASDKERRSMLHTQVGKALSCSTAVDEASTSNVPTISGFSIPKLVLQIITVDAIFRVTSPALHELVLLKEIAFTVYNKARRISRVSCSDLGQSLGISGRPQSTLMHIASPVPGMWKDSVTRITGPSLSRDNELDSGLRPGTWDNSWQTSRTGGINCDPNRSGDILLQDDTRYLFEPLFILAEPGSVEHGISPTMSGSVALESSRPADDNGGGSFMQNTSSLGSADIGPGSLLDGSDLGVLGSSYQKAPSLHCCYGWTEDWRWLISIWTDSRGELLDNHIFPFGGISSRQDTKGLQCLFVQVLQQGCQILSCSPPEIAPAKTRDIVITRIGCFYELECQEWQKAIYTVGGNEVKKWLQLRGSVSDGIPGSSNGTTLQQQEMGLIQERALPSSPSPSLYSPHTKSSGFIKGGIVQNSTRKQLMGGQTTVDSSRGLFQWVQSISLIGVCVDHSLQLAFQPDAPFPGGGTQGGSGNAPSVYLEGFSSIKSVGSVSASYIITPSPSMRFLLPMPLQLPTCLTAESPPLAHLLHSKGSAIPLRTGFVVSKAASSIRKDSRSNAKEEWPSVLSVSLVDYYGTSNITQKIVRGSGTQARTIDNKDGELETHLILESVAAELHSLSWMTVSPAYLERRTALPFHCDMLLRLRRLLHYADKELTQQRETLQV
Length1972
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.186
Instability index53.18
Isoelectric point5.57
Molecular weight212257.03
Publications
PubMed=23663246

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP12733
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1225.51|     351|     378|     365|     734|       1
---------------------------------------------------------------------------
  365-  692 (492.38/376.57)	...................................................SLDGQGID...........SSGIHTL.............................HSNNS.SSNSNSS...SNNSI..SNTSSESDYRNTTRGSDLEADADSLTCRQSGLSSSDQLENDGLKLASKRPRTSMTDSFGQ........TGTV.....INETMQDPY.KSEYNSIEVNNSA.TAGVANDQvgPLWVWddedrATGMDIQTLLSEFGDF....GDFFEndALPFG.EPPGTAESQALLfPvdGGDGSSS.......PCTMGIDVTDQMLLPALGFPSFEG...FNQLP...KDVTEEFNSKNQEIQS.SGPGSNSLAPSTGESDHLSKVEAMMIFAPEYRAIEASISELPSSIFRSPYLPRSRKENSSHS.............SSNVYVYGARPPCSPCLDvsDGKPSIAVNSET
  693-  929 (275.69/200.32)	VPGGCEANsilNLKKYYTYVETEkEKLDRGsLACNNSIISSE.....vvtsSCEGVAPS...........FSGLTST.............................HAVKSvQRNKNGSmfeAGNFLlsSKTVLAADIECIMFQAAM.CRMRHL......LLSSTNLDSSGL................................................................................................................................................................GKFSGgvvSTQLPggtSTVTDKFSSR.YDVKK.....KESI.PVRIAGD....VEGGMLDGP........LNA.PVGVWRSVGVPKGAKSASSPSidgappmphnslnEEGTFVYGQKRPLQGLL...DSMPLLVQQATS
  931- 1336 (457.44/313.04)	VDVALDAD...YGDGPYGWLALE.EQRRRG.FSCGPSNIHAGcggilaschSLDIAGMElldplsanvnvASMLSLLqsdiktalksafgnldgplsildwckgrsQSSDT.GSVANGY...LVEST..SSDLKDSSSTVAVAAGEPVSPPQSSTVSSAGLKVSS..ATDGVRVDENFQRRSNQEICGSesdqrlrpTPTVlplpaILVGYQDDWlKTSANSLQLWEKApLEPYALPK..PMSYY.....VICPDIDPLTSAAADFfqqlGTVYE..ACKLGnHAPQTMESQTEL.P..SGRWLSSgfvimdcPQTMKIESSNASFVGSISDYLLSL...SNGW.....ELTSFLKSLSKVLKSlKLSSSSTMSQKEGVADPCTVIYVVCPY.PEPIAVLQTVVESSAAI..GSIIHASDKERRSML.............HTQV...GKALSCSTAVD..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.36|      11|      63|    1362|    1372|       3
---------------------------------------------------------------------------
 1362- 1372 (19.55/13.97)	DAIFRVTSPAL
 1427- 1437 (19.82/14.31)	DSVTRITGPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.54|      28|      63|     135|     166|       4
---------------------------------------------------------------------------
  135-  166 (41.23/36.79)	C..IERSIRGLSYVRFGDvfsRcLPFLRAEKLFR
  199-  228 (47.31/27.65)	CddMESVLRHLSSNNTGE...R.LPVIIAPHGMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     335.72|     105|     137|    1438|    1550|       5
---------------------------------------------------------------------------
 1438- 1550 (171.74/135.16)	SRDNELDSGLRPGTWDNSWQTSRtgGINCDPNRsgdiLLQDDTRYL.FEPLFIlaEPGSVEHGISPTMSGSVALESS..RPADDNGGGSFMQNTSSL.GSADIG.PGS....LLDGSDLGVL
 1580- 1693 (163.98/108.29)	SRGELLDNHIFPFGGISSRQDTK..GLQCLFVQ....VLQQGCQILsCSPPEI..APAKTRDIVITRIGCFYELECQewQKAIYTVGGNEVKKWLQLrGSVSDGiPGSsngtTLQQQEMGLI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12733 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISPTMSGSVALESSRPADDNGGGSFMQNTS
2) LDGQGIDSSGIHTLHSNNSSSNSNSSSNNSISNTSSESDYRNTTRGSDLEADADSLT
3) LENDGLKLASKRPRTSMTDSFGQTGTVINETMQDPYKSEYNSIEVNNSATA
1500
366
434
1529
422
484










Molecular Recognition Features






MoRF SequenceStartStop




NANANA