<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12723
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MDGNMEISLDKLPIKRLDAIEENGIERFPPDIGHDEKRLSLIRRIDFAWAVEKDTKKQKTSKETTTPWPWQSLVENLQLAHQELSVIIDLINTVEANDAVTVAGMIRPKQLPNEILSDLSVSAATKLQCFRNLGRYFKQSAKGLEQQVAREARFYGALIRLQQNWKVKRQRLPVPAPGSEGFTIDLFDNSLSDPGAIFRPPSISTVRVDHDSAGMLAVHLPQKSCHSLHFGFLGGQSGHKPGKSSKVKIYASDVHQSEEIKKETMSEQDVDQCVKETHSVLREVHRAIFDEQVFDLVSREAFNSSSGVNVIGLRENYLQLRIGQGASVYISLVPSGQDADQTVDNASSDNLGNADSSVDMFEGVKMAEEKYVTPKRKSRFPNPVSCEIYLQQIFHENMFIRAKDRRHSVRRIQASGQPVTDVFGLLGHFCMTLAHRIFANKVLAELEILASRVSYLHLLSHPTWHSRTSSWSLSMKVPQSILHAGHRTRPSDMRSTKSAVRSQFITKVVVNDDCINIEGEGAPNVVGLFKGSAEDICSMNSYDCNLPDLPVILLQQVASQVVRWLHEEALLVGMKASRDFLCLSFELDQGETLGLVAHVDPEDIQGCISWWLVMDDGLMEEGKLHTDFSSDASDTRRFLGHLSLEALYSTLMDLVTLCNSSGSHMFV |
Length | 667 |
Position | Head |
Organism | Nelumbo nucifera (Sacred lotus) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.277 |
Instability index | 48.46 |
Isoelectric point | 6.01 |
Molecular weight | 74606.97 |
Publications | PubMed=23663246
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP12723
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 35.78| 14| 15| 243| 256| 1
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239- 254 (17.07/10.00) HKpgKSSKVKIYASDV
255- 270 (18.71/11.60) HQseEIKKETMSEQDV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 307.45| 100| 239| 73| 174| 2
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73- 174 (162.15/108.67) LVEN.LQL.AHQELSVIIDLINTveANDAVTVAGMIRPKQLPNEILS.DL..SVS.AATKLQCFRNLGRYFKQ.SAKGLEQQVAREARFYGALIRLQQNWKVKRQRLPV
313- 419 (145.30/91.83) LRENyLQLrIGQGASVYISLVPS..GQDADQTVDNASSDNLGNADSSvDMfeGVKmAEEKYVTPKRKSRFPNPvSCEIYLQQIFHENMFIRAKDRRHSVRRIQASGQPV
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