<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12710

Description mediator of RNA polymerase II transcription subunit 15a isoform X2
SequenceMDNNNWRPTQGEPAMPSMPTMDNSDWRSQLQPDSRQRIVNKIMDTLKKHLPISGPEGLQELKKIAVRFEEKIYTAASSQSDYLRKISLKMLTMESKSQPNVVPNSLPSNSAGSNPNPVDPASQSMQSQVRNQGQPLPISMPNQARQQMLSQTVQNNIAPAGVQNSSGLSSAHPSVSGLSQNTVPNRQMQGRQLQQQAIPQQLQQQPQNPQYIYHQQQQQLQQQFLKQKIQQGNLQQQPLMQPHIQQQQQQQQQQQQQQLLQPTQLQSSQQSLMHISSSLPSSQPPLQQTQSSVIQSTPHSSLQQNQQPSIQPSTASVLQQHPQSVHRQQQQPQQSLHQQAPVLLQQQTPMSQQTLLSSQQQQLIGQQTNATSIQQNQLVAQQNSVPDIQQPQQQQQQPQPQPPLQQSQQQQQQQQQRLLSQQSNLSNMQQMGSQSNVSGLQQQQQQRQQQLLASQSSVSNIHPNQHSVNMLQQVKVATQQQANQQTPAVLSSQGQQSQPQPQQQQIMSHLQPQSGQIQPQIGLQQQSNPLQRDMQQRLQTSGALLQPQNAIEQQKQLFQSQRMLPEASSTSIESTAQTGHANAIDLQEEVYQKIKSMKEMYLPEINEMYQKIALKCQQNDSLPQPQKSDHVDRLRMFRTMLERIIQFLSVAKTTCLLYKDKLPLLEKQIVGVLNTNRPKKPVPSQLQGQQQLQPPGALLHSIQPQQQQQQQQPQPQIPHLKQQQHDNQMHPQVQPINLQSSVTSMQPTSVPTMQHSSIPPVSNHLAVTNAQPNVMTSLQSSSNLEPGQGNAPNSLQQGAVGSLQQSTMSTTQQTNITTLSQSSVNTLQPSIGSLQPNTNMLQHQHLKQQQEQQLIQSQQLKQQFQQRPVHQQLLQQQKQQILQQQQQQQQQFQQQQQPQQQVHQQKPQQSSQLPVHQMPQLHMNEVNDLKVRQGMGVKPGIFQQHHSASQRPAYHQQLKAGASFPISSPQLLQAASPQISQHSSPQIDQQSLLSSLTKAGTPLQSANSPFVVPSPSPPLAPSPIPGDSEKQTSAVSSLSTAGNIGHPQTSVAIAPAQSLAIGTPGISASPLLAEFTGPDGNQGTASTMISGKSVVTEQPLERLIKVVKSMSTKALCASVSDIGSVVCMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFISQDGSSATKKMRRYTIAMPLNAVSSAGSVNDSFKQLNGLETSDLESTATSRIKRPRVEANHALLEEIRETNQRLIDTVVDISDEDIDPTTGAAVVEGGEGTIVKCSFSAVALSPNLKSQYASAQMSPILPIRLLVPTNYPKCSPILLDRLPVELSKEYEDLSVKAKSRFSASLRSLSQPMSLWEMAKTWDICARAVVSEYAQQSGGGSFSSRYGTWENCVSAS
Length1386
PositionTail
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.03
Grand average of hydropathy-0.764
Instability index82.04
Isoelectric point9.41
Molecular weight153270.15
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12710
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.31|      31|      31|     846|     876|       1
---------------------------------------------------------------------------
  212-  242 (43.38/ 7.87)	IYHQQQQQL.QQQFLKQKIQQGNLQQQpLMQP
  686-  712 (41.56/ 7.10)	LQGQ..QQLQPPGALLHSIQPQ..QQQ.QQQQ
  846-  876 (56.37/13.31)	LKQQQEQQLIQSQQLKQQFQQRPVHQQ.LLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     184.96|      32|      32|     396|     427|       2
---------------------------------------------------------------------------
  178-  209 (43.24/ 7.09)	LSQ....NTVPNRQMQGRQLQQQAIPQQ.LQ.........QQPQNP
  244-  285 (47.30/ 8.70)	IQQ....QQQQQQQQQQQQLLQPTQLQSsQQslmhissslPSSQPP
  404-  436 (52.08/10.59)	LQQ....SQQQQQQQQQRLLSQQSNLSNmQQ.........MGSQSN
  471-  506 (42.34/ 6.74)	LQQvkvaTQQQANQQTPAVLSSQGQQSQ.PQ.........PQQQQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     415.19|      55|      55|     295|     349|       3
---------------------------------------------------------------------------
  311-  364 (90.55/19.44)	QPS..TASVLQQHPQSVHRQQQ............................................QP..QQSLHQQAPVLLQQQT.PmsQQTLL..................................SS................QQQQLI
  366-  448 (49.29/ 6.77)	QQT..NATSIQQN.QLVAQQNS............................................VPdiQQP..QQ.....QQQQ.PqpQPP..lqqsqqqqqqqqqrllsqqsnlsnmqqmgsqsnvSGLQQ.............QQQQRQ
  449-  538 (60.64/10.25)	QQL..LAS..QSSVSNIHPNQHsvnmlqqvkvatqqqanqqtpavlssqgqqsqpqpqqqqimshlQP...QSGQIQPQIGLQQ......QSNP.....................................LQR.............DMQQRL
  714-  774 (57.33/ 9.24)	QPQ..IPHLKQQQ....HDNQM............................................HP..Q....VQP.INLQSSV.TsmQPTSV..................................PTMQHssippvsnhlavtNAQPNV
  775-  827 (57.28/ 9.22)	MTS..L.....QSSSNLEPGQG............................................NA..PNSLQQGAVGSLQQSTmSttQQTNI..................................TTLSQ.............SSVNTL
  828-  898 (52.43/ 7.73)	QPS..IGS.LQPN.TNMLQHQH.............lkqqqeqqliqsqqlkqqfqqrpvhqqllqqQK..QQILQQQQ....QQ......QQ........................................QF.............QQQQQP
  956-  996 (47.67/ 6.27)	QQLkaGASFPISSPQLL..QAA............................................SP..QISQHSSPQI..DQ......QS.LL..................................SSL.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     151.35|      39|     121|      10|      54|       4
---------------------------------------------------------------------------
    1-   19 (31.84/ 9.47)	.MDNNNWRP....................tQGEP.....AMP.SMP
   20-   48 (41.38/20.95)	TMDNSDWRSQLQPDSRQRIVNKIMDTLKK.................
   79-  110 (28.63/ 7.77)	...........QSDYLRKISLKMLTMESK..SQPnvvpnSLP.SNS
  111-  141 (49.50/18.83)	AGSNPN...PVDPAS.QSMQSQVRN.....QGQP......LPiSMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.51|      19|     110|    1137|    1159|       5
---------------------------------------------------------------------------
 1137- 1159 (27.05/35.58)	PGNGsrAAV...GEDlvAMTKCRLQA
 1251- 1272 (30.46/22.77)	PTTG..AAVvegGEG..TIVKCSFSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.31|      18|      37|    1011|    1028|       7
---------------------------------------------------------------------------
 1011- 1028 (33.01/15.03)	VVPSPSPPLAPSPIPGDS
 1076- 1093 (27.30/11.01)	TGPDGNQGTASTMISGKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.42|      14|      16|    1289|    1302|       8
---------------------------------------------------------------------------
 1289- 1302 (27.08/17.04)	SPILPIRLLV..PTNY
 1306- 1321 (21.33/11.84)	SPILLDRLPVelSKEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.96|      16|      21|     589|     604|       9
---------------------------------------------------------------------------
  589-  604 (28.30/15.73)	EVYQKI..KSMKEMYLPE
  607-  624 (23.66/11.70)	EMYQKIalKCQQNDSLPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.69|      12|      22|     640|     653|      10
---------------------------------------------------------------------------
  640-  653 (15.38/15.80)	MLERiiQFLSVAKT
  664-  675 (19.30/11.74)	LLEK..QIVGVLNT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12710 with Med15 domain of Kingdom Viridiplantae
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