<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12708

Description mediator of RNA polymerase II transcription subunit 15a isoform X1
SequenceMDNNNWRPTQGEPAMPSMPTMDNSDWRSQLQPDSRQRIVNKIMDTLKKHLPISGPEGLQELKKIAVRFEEKIYTAASSQSDYLRKISLKMLTMESKSQPNVVPNSLPSNSAGSNPNPVDPASQSMQSQVRNQGQPLPISMPNQARQQMLSQTVQNNIAPAGVQNSSGLSSAHPSVSGLSQNTVPNVGGQNSNLPNMSGISQNSVSNPLGQSVTSNMFANSQRQMQGRQLQQQAIPQQLQQQPQNPQYIYHQQQQQLQQQFLKQKIQQGNLQQQPLMQPHIQQQQQQQQQQQQQQLLQPTQLQSSQQSLMHISSSLPSSQPPLQQTQSSVIQSTPHSSLQQNQQPSIQPSTASVLQQHPQSVHRQQQQPQQSLHQQAPVLLQQQTPMSQQTLLSSQQQQLIGQQTNATSIQQNQLVAQQNSVPDIQQPQQQQQQPQPQPPLQQSQQQQQQQQQRLLSQQSNLSNMQQMGSQSNVSGLQQQQQQRQQQLLASQSSVSNIHPNQHSVNMLQQVKVATQQQANQQTPAVLSSQGQQSQPQPQQQQIMSHLQPQSGQIQPQIGLQQQSNPLQRDMQQRLQTSGALLQPQNAIEQQKQLFQSQRMLPEASSTSIESTAQTGHANAIDLQEEVYQKIKSMKEMYLPEINEMYQKIALKCQQNDSLPQPQKSDHVDRLRMFRTMLERIIQFLSVAKTTCLLYKDKLPLLEKQIVGVLNTNRPKKPVPSQLQGQQQLQPPGALLHSIQPQQQQQQQQPQPQIPHLKQQQHDNQMHPQVQPINLQSSVTSMQPTSVPTMQHSSIPPVSNHLAVTNAQPNVMTSLQSSSNLEPGQGNAPNSLQQGAVGSLQQSTMSTTQQTNITTLSQSSVNTLQPSIGSLQPNTNMLQHQHLKQQQEQQLIQSQQLKQQFQQRPVHQQLLQQQKQQILQQQQQQQQQFQQQQQPQQQVHQQKPQQSSQLPVHQMPQLHMNEVNDLKVRQGMGVKPGIFQQHHSASQRPAYHQQLKAGASFPISSPQLLQAASPQISQHSSPQIDQQSLLSSLTKAGTPLQSANSPFVVPSPSPPLAPSPIPGDSEKQTSAVSSLSTAGNIGHPQTSVAIAPAQSLAIGTPGISASPLLAEFTGPDGNQGTASTMISGKSVVTEQPLERLIKVVKSMSTKALCASVSDIGSVVCMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFISQDGSSATKKMRRYTIAMPLNAVSSAGSVNDSFKQLNGLETSDLESTATSRIKRPRVEANHALLEEIRETNQRLIDTVVDISDEDIDPTTGAAVVEGGEGTIVKCSFSAVALSPNLKSQYASAQMSPILPIRLLVPTNYPKCSPILLDRLPVELSKEYEDLSVKAKSRFSASLRSLSQPMSLWEMAKTWDICARAVVSEYAQQSGGGSFSSRYGTWENCVSAS
Length1422
PositionTail
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.03
Grand average of hydropathy-0.757
Instability index81.13
Isoelectric point9.41
Molecular weight156919.05
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12708
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     177.48|      31|      31|     882|     912|       1
---------------------------------------------------------------------------
  229-  264 (43.08/ 6.67)	LQQQAIPQQ.LQQQpqnpqyI...YHQQQQQ.L.QQQFLKQ.K
  265-  298 (44.85/ 7.33)	IQQGNLQQQpLMQP.......hiqQQQQQQQ.QQQQQQLLQ.P
  738-  766 (41.48/ 6.08)	IQPQ..QQQ.QQQQ......P...QPQIP.H.LKQQQHDNQmH
  900-  927 (48.07/ 8.52)	FQQRPVHQQ.LLQQ.............QKQQiLQQQQQQQQ.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.72|      31|      31|     433|     463|       2
---------------------------------------------------------------------------
  434-  463 (54.28/13.14)	.PQPQPPLQQSQQQQQQ.QQQRLLSQQSN.LSN
  466-  496 (49.13/10.93)	QMGSQSNVSGLQQQQQQ.RQQQLLASQSS.VSN
  536-  568 (38.32/ 6.31)	QPQQQQIMSHLQPQSGQiQPQIGLQQQSNpLQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     442.25|      81|      81|     975|    1055|       5
---------------------------------------------------------------------------
  344-  422 (87.17/16.36)	...........PSIqpstasvLQQHpqsvHRQQQQPqqSLHQQ..........APV......LLQQQTP.MSQQtllSS................................QQQQLIGQQT....NA.T..SIQ..QNQLVAQQNSVP
  718-  796 (69.58/11.61)	V..........P.............................SQL..............QGQQQLQ..PPGALLH...S.iqpqqqqqqqqpqpqiphlkqqqhdnqmhPQVQPINLQSSV........T..SMQPTSVPTMQHSSIPP
  797-  862 (70.53/11.87)	VsnhlavtnaqPNV.......M.........TSLQ...S.SSNLEPG......QG...NAPNSLQQGAVGSLQQ...ST.............................MSTTQQ......T....NI.T..TLS..QSSVNT......
  975- 1054 (138.69/30.28)	...........PGI.......FQQH....HSASQRP..AYHQQLKAG......ASFPISSPQLLQAASPQISQH...SS.............................PQIDQQSLLSSLT....KAGT..PLQSANSPFVVPSPSPP
 1055- 1138 (76.27/13.42)	L.....apspiPG................DSEKQTS..AVSSLSTAGnighpqTSVAIAPAQSLAIGTPGIS.....AS.............................P......LLAEFTgpdgNQGTasTMISGKS.VVTEQPLER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.90|      30|      83|     104|     134|       7
---------------------------------------------------------------------------
  104-  134 (54.04/34.57)	NS...........................LPsNSAGSNPNPV.DPASQSM......QSQVRNQGQ
  164-  227 (28.86/11.09)	NSsglssahpsvsglsqntvpnvggqnsnLP.NMSGISQNSVsNPLGQSVtsnmfaNSQRQMQGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.16|      19|      54|     516|     534|       8
---------------------------------------------------------------------------
  516-  534 (29.17/11.38)	QQANQQTPAVLSSQGQQSQ
  571-  589 (29.34/11.51)	QQRLQTSGALLQPQNAIEQ
  590-  608 (25.65/ 8.79)	QKQLFQSQRMLPEASSTSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.42|      14|      16|    1325|    1338|       9
---------------------------------------------------------------------------
 1325- 1338 (27.08/25.04)	SPILPIRLLV..PTNY
 1342- 1357 (21.33/17.44)	SPILLDRLPVelSKEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.93|      12|      17|       1|      13|      10
---------------------------------------------------------------------------
    1-   13 (22.17/17.70)	MDNNNWRpTQGEP
   21-   32 (25.75/14.57)	MDNSDWR.SQLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.76|      15|      55|      86|     103|      12
---------------------------------------------------------------------------
   71-   85 (23.61/17.82)	KIYTAASSQSDYLRK
   89-  103 (25.15/ 9.89)	KMLTMESKSQPNVVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.52|      53|     120|    1151|    1204|      13
---------------------------------------------------------------------------
 1151- 1204 (84.71/62.91)	LcASVSDIGSVVCMIDRIAG........SAPGNGSRAAVGEDLVAMTKCRLQA....RNFISQDGS
 1219- 1274 (57.08/36.01)	L.NAVSSAGSVNDSFKQLNGletsdlesTATSRIKRPRVEANHALLEEIRETN....QRLI.....
 1276- 1321 (56.73/35.44)	...TVVDISD..EDIDPTTG........AAVVEG.....GEG..TIVKCSFSAvalsPNLKSQYAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.56|      16|      17|     624|     640|      14
---------------------------------------------------------------------------
  625-  640 (29.88/24.16)	EVYQKI..KSMKEMYLPE
  643-  660 (26.68/14.23)	EMYQKIalKCQQNDSLPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.44|      12|     161|     701|     712|      17
---------------------------------------------------------------------------
  677-  690 (14.72/10.24)	LERiiQFLSVAKTT
  701-  712 (19.72/17.01)	LEK..QIVGVLNTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.92|      15|      21|     931|     945|      20
---------------------------------------------------------------------------
  931-  945 (28.76/12.20)	QQQPQ...QQVHQQKPQQ
  952-  969 (22.15/ 7.22)	HQMPQlhmNEVNDLKVRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12708 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FQQQQQPQQQVHQQKPQQSSQLPVHQMPQLHMNEVNDLKVRQGMGVKPGIFQQHHSASQRPAYHQQLKAGASFPISSPQLLQAASPQISQHSSPQIDQQSLLSSLTKAG
2) LLASQSSVSNIHPNQHSVNMLQQVKVATQQQANQQTPAVLSSQGQQSQPQPQQQQIMSHLQPQSGQIQPQIGLQQQSNPLQRDMQQRLQTSGALLQ
3) LQSANSPFVVPSPSPPLAPSPIPGDSEKQTSAVSSLSTA
4) MDNNNWRPTQGEPAMPSMPTMDNSDWRSQLQPDSRQRIVNKIMDTLKKHLPISGPEGLQEL
5) QQQQLLQPTQLQSSQQSLMHISSSLPSSQPPLQQTQSSVIQSTPHSSLQQNQQPSIQPSTASVLQQHPQSVHRQQQQPQQSLHQQAPVLLQQQTPMS
6) QQRLLSQQSNLSNMQQMGSQSNVSGLQQQQQQ
7) SIQQNQLVAQQNSVPDIQQPQQQQQQPQPQPPLQQSQQQQQQ
8) TMESKSQPNVVPNSLPSNSAGSNPNPVDPASQSMQSQVRNQGQPLPISMPNQARQQMLSQTVQNNIAPAGVQNSSGLSSAHPSVSGLSQNTVPNVGGQNSNLPNMSGISQNSVSNPLGQSVTSNMFANSQRQMQGRQLQQQAIPQQLQQQPQNPQYIYHQQ
9) VLNTNRPKKPVPSQLQGQQQLQPPGALLHSIQPQQQQQQQQPQPQIPHLKQQQHDNQMHPQVQPINLQSSVTSMQPTSVPTMQHSSIPPVSNHLAVTNAQPNVMTSLQSSSNLEPGQGNAPNSLQQGAVGSLQQSTMSTTQQTNITTLSQSSVNTLQPSIGSLQPNTNMLQHQHLKQQQEQQLI
928
487
1039
1
291
451
408
92
708
1036
582
1077
61
387
482
449
252
891










Molecular Recognition Features






MoRF SequenceStartStop




1) KISLKMLT
85
92