<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12698

Description mediator of RNA polymerase II transcription subunit 12 isoform X3
SequenceMQRYSATSSGDGVSSGTVGGSARDTARVDSSFSSSNFSLSSRRPSQLTSYKLKCDKEPLNCRLGPPDFYPQFPNCPEETLTREYVQYGYKETIEGLEEAREILLSQLITFSKPVALKCKEAIRKRLRAINESRAQKHKAGQVYGVPLSGSLLLKPGAFPEQKPCGEDSRKKWIEGLSQQHKCLHFLADNVPHGFRRKDLFEVLIRHNIPLLRATWFIKVSYLNQIRPLSVNVSSGTTDKTQLARTDLWTKDIVEYLQYLLDEFFSVNRDESPQILLAGSVHKGDSSLGLTESEEPSLYFKWWYMVRIIRWHHSEGLLYPSLVIDWVLNQLQDKESLETLQLLLPIIYGLIETIVLSQTYVHNLVEVAVRSIQESSSGSDLVDNSQKAYIASAMVEMLWYLIVAVPDTFVALDCFPLPLPVLSGVANRRFFLSKVSEDAEKTRNGAEELLTLYGEKRQVAHHHFLTFDYVVSSIQKRADNLVKAVSPVPQGHGVAKAVQALDKALTLGDLKRAYNFLFEDLCDGCIEEIWIAKFTGRKDFSQVYIAVLLLKMKIEDMHTSNQCKNGSTFGANNLGRDASHHDSFSGGVTGENVSIRKNKSKNLGGRIDSSDIFESPGPVHDIIVCWIDQHEVGKGEGFKRLQLLIMELICSGIFNPPAYARQLIVSGIMDRSETLVDLDRRRRHYFVLKQLPGAYMLDFLEVRIADISALEEALNVYSNERRLLLHGLLSDLTSHSRNGNDNNVNIDFQKQKNNPSSGQNAPGPLSGRNAKTKAQVAELKEAISILLHLPSSYSTLPDTRSDESQRSCKRSIWLIGKKMDVTEGTPGCKEYRRSKKQKSSEERSSYMQGFSPNPSNDEDSWWVRKVPKSIESFKVDPPLKSTKNTSRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNRISCPHHRTSIEGEASKPVDGMRATHLGDVVLIGKALKQLRLLEKRAITVWLMSLVRQLVEGSEKSAAKVGHRTGHLPPSDDKSSVRWKLSEDELSSILYLMDISSDLVSAVKFLLWLLPKVLSTPNSTHGGRSILMLPKNTESRSCEVGEAFLLSSIRRYESILVAADLIPEVLCASMVRAAAVMASNGRASGSAAFVYARNLLKKYGNMVSVEKWEKNFKATSDQRLLVELESGRSLDENLGFSLGVPAGVDDLDDYFRQKLSGRLTRPIPSMKEMVQKHVDEAMHSFFGKERKLFAAGTPKGPVIEKCDDGYRIAQQIVLGLIECTRQNSSTSQEVDPFIVASAVSAIVANVGPALAKMPDFTASGNYQSFPSPITSLNCARHILRIHIACLSLLKEAIGERQSRVFEIALSIEASSAVAAALAPGKGSRSQFQLSPEAHDSSTNLSNEMLTNYTKVFIGRATKAAAAVSALVIGAVVHGAASLERMVSALRLKEGLDILQFVRSAKSSSNGISRSVSAFKVDNSIEVYLHWFRLLVGNYRTVSDGLIVELLGEPYILALSRMQRMLPLSLVLPPAYSIFALMLWRPYVLNSNTITHDVQLNQSLASAIGEAITHQPFRDVCLRDTCAFYDLLASDVANSEFVAMLEMHGADKHMKTMAFVPLRARLFLNAILDCKIPQSMISQDDGVQVSGSAESKLQHTKSEIKLQDQLVHVLDTLQPAKFHWQWVELRLLLNEQALIEKIDTHNMSFVEAIRSLFPNSDNSVLSENENNFNEIILTRLLVRPDASPLYSEVVHLLGKSLEESLLLHAKWFLAGHDVLFGRKSIRQRLINVAQLRGLSTKIQFWKPWGWPHSAADLAASKGERKKFEVSSLEEGEVVEEGIDFKRLGRVTTQILDAEVFNSSQQYATERALIELVLPCIDRSSSESRNTFANELIKQMNNIEQQINAVTHGINKQAGAVPSGIEGSTSKSSSRKGTRHGSPGLGRRLIGLSDSAPPSSAALRASMWLRLQFLLRFLPLIYADRELSSRNMRQMLASIILRLLGSRVVHEDADLSYQIQSSPSKREVESPMEPAVIASLDLSGDSLFDRFLSILHGLLSSCKPRWLKPKSASKSTVKSPRDFSVFDREAAESLQNDLDHMQLPETIRWRLQAAMPMPPPPSFSITCQPPTISSAAIASLQSPVFQHGNSNLPQKNLLPSSRAPASILGKLKQSQTQDQVMEVDPWTLLEDGSGLGSSLNNNSGVGATGDHANLKACNWLKGAVRVRRTDLTYIGAVDDR
Length2203
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.232
Instability index51.21
Isoelectric point8.74
Molecular weight244571.76
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12698
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     237.54|      73|     556|    1118|    1373|       1
---------------------------------------------------------------------------
  344-  421 (116.11/15.94)	PIIYGLIETIVLSQTYVHNLVEVAvrsiQESSSGSDLVDNSQKAYIASAMVEMLWYLIVAVPDtFVA...LDCFPLPLPVL
 1226- 1301 (121.43/305.10)	PVIEKCDDGYRIAQQIVLGLIECT....RQNSSTSQEVDPFIVASAVSAIVANVGPALAKMPD.FTAsgnYQSFPSPITSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     610.05|     204|     993|     961|    1174|       2
---------------------------------------------------------------------------
  961- 1174 (307.67/208.08)	RLLEKRAITVWLMSLVRQLVeGSE..KSAAKVGHRTGHLP.......PSDDKSSVRWKLSEDELSSilYLMDISSDLVSAVKfLLWLLPKVlSTPNSTHGGRSILMLPKN.TESRSCEVGEAFLLSSIR.RYESilvAADLIP....EVLC.ASMVRAAAV..MASNGRASGSAAfVYARNLLKKYGNMVSVEKWEKNfKATSDQRLLVE....LESGRSLDENLGFSLGVPAGVD
 1948- 2173 (302.38/174.36)	RELSSRNMRQMLASIILRLL.GSRvvHEDADLSYQIQSSPskrevesPMEPAVIASLDLSGDSLFD..RFLSILHGLLSSCK.PRWLKPKS.ASKSTVKSPRDFSVFDREaAESLQNDLDHMQLPETIRwRLQA...AMPMPPppsfSITCqPPTISSAAIasLQSPVFQHGNSN.LPQKNLLPSSRAPASILGKLKQ.SQTQDQVMEVDpwtlLEDGSGLGSSLNNNSGVGATGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.34|      39|    1463|     210|     248|       3
---------------------------------------------------------------------------
  210-  248 (68.86/43.41)	LLRATWFI...KVSY.LNQIRPLSVNVSS..GTTDKTQLARTDLW
 1730- 1774 (59.47/36.45)	LLHAKWFLaghDVLFgRKSIRQRLINVAQlrGLSTKIQFWKPWGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.79|      29|    1463|     122|     150|       4
---------------------------------------------------------------------------
  122-  150 (50.01/37.88)	IRKR..LRAINESRAQKHKAGQVYGVPLSGS
 1586- 1616 (45.78/33.91)	LRARlfLNAILDCKIPQSMISQDDGVQVSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.01|      25|     556|    1348|    1373|       5
---------------------------------------------------------------------------
 1348- 1373 (42.30/29.80)	PGKGsRSQFQLSPEAHDSSTNLSNEM
 1906- 1930 (44.71/26.92)	PGLG.RRLIGLSDSAPPSSAALRASM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.72|      16|      39|     611|     626|       7
---------------------------------------------------------------------------
  611-  626 (32.53/23.77)	IFESPGPVHDIIVCWI
  652-  667 (29.19/20.41)	IFNPPAYARQLIVSGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.75|      15|     635|     699|     713|       8
---------------------------------------------------------------------------
  699-  713 (23.21/15.91)	LEV..RIADISALEEAL
 1308- 1322 (23.97/16.72)	LRI..HIACLSLLKEAI
 1330- 1346 (16.57/ 8.79)	FEIalSIEASSAVAAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.25|      30|    1169|     526|     555|      12
---------------------------------------------------------------------------
  526-  555 (51.11/41.44)	EEIWIAKFTGRKDFSQVYIAVL.LLKMKIED
 1697- 1727 (44.13/34.50)	NEIILTRLLVRPDASPLYSEVVhLLGKSLEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12698 with Med12 domain of Kingdom Viridiplantae
Unable to open file!