<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12695

Description mediator of RNA polymerase II transcription subunit 12 isoform X2
SequenceMQRYSATSSGDGVSSGTVGGSARDTARVDSSFSSSNFSLSSRRPSQLTSYKLKCDKEPLNCRLGPPDFYPQFPNCPEETLTREYVQYGYKETIEGLEEAREILLSQLITFSKPVALKCKEAIRKRLRAINESRAQKHKAGQVYGVPLSGSLLLKPGAFPEQKPCGEDSRKKWIEGLSQQHKCLHFLADNVPHGFRRKDLFEVLIRHNIPLLRATWFIKVSYLNQIRPLSVNVSSGTTDKTQLARTDLWTKDIVEYLQYLLDEFFSVNRDESPQILLAGSVHKGDSSLGLTESEEPSLYFKWWYMVRIIRWHHSEGLLYPSLVIDWVLNQLQDKESLETLQLLLPIIYGLIETIVLSQTYVHNLVEVAVRSIQESSSGSDLVDNSQKAYIASAMVEMLWYLIVAVPDTFVALDCFPLPLPVLSGVANRRFFLSKVSEDAEKTRNGAEELLTLYGEKRQVAHHHFLTFDYVVSSIQKRADNLVKAVSPVPQGHGVAKAVQALDKALTLGDLKRAYNFLFEDLCDGCIEEIWIAKVSPCLQSSLKWMGTVSFSFICSLFFLFEWATCDFRDFRTSLPCDLKFTGRKDFSQVYIAVLLLKMKIEDMHTSNQCKNGSTFGANNLGRDASHHDSFSGGVTGENVSIRKNKSKNLGGRIDSSDIFESPGPVHDIIVCWIDQHEVGKGEGFKRLQLLIMELICSGIFNPPAYARQLIVSGIMDRSETLVDLDRRRRHYFVLKQLPGAYMLDFLEVRIADISALEEALNVYSNERRLLLHGLLSDLTSHSRNGNDNNVNIDFQKQKNNPSSGQNAPGPLSGRNAKTKAQVAELKEAISILLHLPSSYSTLPDTRSDESQRSCKRSIWLIGKKMDVTEGTPGCKEYRRSKKQKSSEERSSYMQGFSPNPSNDEDSWWVRKVPKSIESFKVDPPLKSTKNTSRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNRISCPHHRTSIEGEASKPVDGMRATHLGDVVLIGKALKQLRLLEKRAITVWLMSLVRQLVEGSEKSAAKVGHRTGHLPPSDDKSSVRWKLSEDELSSILYLMDISSDLVSAVKFLLWLLPKVLSTPNSTHGGRSILMLPKNTESRSCEVGEAFLLSSIRRYESILVAADLIPEVLCASMVRAAAVMASNGRASGSAAFVYARNLLKKYGNMVSVEKWEKNFKATSDQRLLVELESGRSLDENLGFSLGVPAGVDDLDDYFRQKLSGRLTRPIPSMKEMVQKHVDEAMHSFFGKERKLFAAGTPKGPVIEKCDDGYRIAQQIVLGLIECTRQNSSTSQEVDPFIVASAVSAIVANVGPALAKMPDFTASGNYQSFPSPITSLNCARHILRIHIACLSLLKEAIGERQSRVFEIALSIEASSAVAAALAPGKGSRSQFQLSPEAHDSSTNLSNEMLTNYTKVFIGRATKAAAAVSALVIGAVVHGAASLERMVSALRLKEGLDILQFVRSAKSSSNGISRSVSAFKVDNSIEVYLHWFRLLVGNYRTVSDGLIVELLGEPYILALSRMQRMLPLSLVLPPAYSIFALMLWRPYVLNSNTITHDVQLNQSLASAIGEAITHQPFRDVCLRDTCAFYDLLASDVANSEFVAMLEMHGADKHMKTMAFVPLRARLFLNAILDCKIPQSMISQDDGVQVSGSAESKLQHTKSEIKLQDQLVHVLDTLQPAKFHWQWVELRLLLNEQALIEKIDTHNMSFVEAIRSLFPNSDNSVLSENENNFNEIILTRLLVRPDASPLYSEVVHLLGKSLEESLLLHAKWFLAGHDVLFGRKSIRQRLINVAQLRGLSTKIQFWKPWGWPHSAADLAASKGERKKFEVSSLEEGEVVEEGIDFKRLGRVTTQILDAEVFNSSQQYATERALIELVLPCIDRSSSESRNTFANELIKQMNNIEQQINAVTHGINKQAGAVPSGIEGSTSKSSSRKGTRHGSPGLGRRLIGLSDSAPPSSAALRASMWLRLQFLLRFLPLIYADRNMRQMLASIILRLLGSRVVHEDADLSYQIQSSPSKREVESPMEPAVIASLDLSGDSLFDRFLSILHGLLSSCKPRWLKPKSASKSTVKSPRDFSVFDREAAESLQNDLDHMQLPETIRWRLQAAMPMPPPPSFSITCQPPTISSAAIASLQSPVFQHGNSNLPQKNLLPSSRAPASILGKLKQSQTQDQVMEVDPWTLLEDGSGLGSSLNNNSGVGATGDHANLKACNWLKGAVRVRRTDLTYIGAVDDR
Length2244
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.215
Instability index50.94
Isoelectric point8.69
Molecular weight249342.36
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12695
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.12|      46|     642|     824|     869|       1
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  824-  869 (79.91/49.02)	LKEAISILLHLPSSYSTLPDTRSDESQRSCKRSI.....W...LIGKKMDVTEG
 1462- 1515 (66.21/39.26)	LKEGLDILQFVRSAKSSSNGISRSVSAFKVDNSIevylhWfrlLVGNYRTVSDG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     267.56|      87|     140|     188|     278|       2
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  188-  278 (141.40/106.36)	DNVPHGFRRKDLFEVLiRHNIPL...LRATWFIKVSYLNQIRPLSV....NVSSGT..TDKTQLArtdLWTKDIVEYLQYLL....DEFFSVNRDESPQILLAG
  324-  423 (126.17/83.18)	DWVLNQLQDKESLETL.QLLLPIiygLIETIVLSQTYVHNLVEVAVrsiqESSSGSdlVDNSQKA...YIASAMVEMLWYLIvavpDTFVALDCFPLPLPVLSG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.90|      22|      40|     655|     676|       3
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  655-  676 (44.26/32.20)	SDIFESPGPVHDIIVCWI.DQHE
  696-  718 (35.64/24.21)	SGIFNPPAYARQLIVSGImDRSE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.79|      29|    1509|     122|     150|       4
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  122-  150 (50.01/29.88)	IRKR..LRAINESRAQKHKAGQVYGVPLSGS
 1632- 1662 (45.78/26.72)	LRARlfLNAILDCKIPQSMISQDDGVQVSGS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.07|      60|     639|    1031|    1090|       6
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 1031- 1090 (98.78/63.09)	KSAAKVGHRTG..HLPPSDDKSSVR..........WKLSEDELSSILYLMDISSDLVSAVKFLLWLLPKVLS
 1937- 1992 (75.24/45.97)	.STSKSSSRKGtrHGSPGLGRRLIG..........LSDSAPPSSAAL.....RASMWLRLQFLLRFLPLIYA
 2014- 2074 (69.05/41.47)	HEDADLSYQ.....IQSSPSKREVEspmepaviasLDLSGDSLFD..RFLSILHGLLSSCK.PRWLKPK...
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.11|      33|     582|    1164|    1197|       8
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 1164- 1197 (52.75/40.18)	FVYA.RNLLKKYGNMVSVEKwEKNFKATSDQRLLV
 1719- 1752 (52.36/33.42)	FVEAiRSLFPNSDNSVLSEN.ENNFNEIILTRLLV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.51|      57|     602|    1229|    1287|       9
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 1229- 1287 (91.03/59.48)	KLSGrLTRPIPSMKEMVQKHVDEAMHSFFGKERKLFAAGTPKGPVIEKCDD....GyRIAQQI
 1804- 1864 (93.49/52.58)	QLRG.LSTKIQFWKPWGWPHSAADLAASKGERKKFEVSSLEEGEVVEEGIDfkrlG.RVTTQI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.71|      30|      40|     493|     522|      10
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  493-  522 (51.16/35.33)	VAKAVQALDKALT.LGDLKRAYN....FLFE.DLCD
  530-  565 (39.55/25.38)	IAKVSPCLQSSLKwMGTVSFSFIcslfFLFEwATCD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12695 with Med12 domain of Kingdom Viridiplantae
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