<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12691

Description mediator of RNA polymerase II transcription subunit 15a-like
SequenceMDNNNWRPAQGEPALPTMSTMDNTDWRAQLPLDARQRIANKIMETLKKHLPISGPDGLQELKKIAGRFEEKIYTAATSQADYLRKISLKMLTMETKSQPNIVPNSLPSNSAGGNPNPVDPASQSMQSQVHNQGMSLPISMPNQARQHMLPQTIQNNILPSGVQNSVSLPSVQSSVSGLTQNTIPNASGQSSNMPNVSGISQNPVSNPLAQGVPSSVFPTSQRQMPGRQLQQQVIPQQLQQQSQNSQQYIYPQKQLQQQILKPKIQQGNIQQQSLMQQHIQQQQQQQQRQQNLLQPTQLQSSQQSLMQVSSGLPSSQSSLQHTQPSVMQSAPHSVLQQNQQTSIQSSTSLVLQQHQQSVLGQQQQSQQSLHQQPPVLQHQTPLSQQTLLSSQQQQLIGQQPNATNMQQNQLVAQQNSVPHVQKTQQQQQTQPQPPLQQQQQQQQQQQQRLLSQQNNLSNMQQLGSQSYVPGLQQQQLLSPQSSVSNMQPNRHSVNMLQQVKLVAQKQQTQQTSLTVLPTQGQQSQSQPQQQQMMSHLPTQPGQLQQQLGLQQQSNSLQRDMQQRIQTSSALPHSQNAIEPPKQLFQSQRMLPEASSTSIDSAAQPGHANADLQEEVYEKIKAMKEMYLPEINEMYQKIALKCHQNDSLPQPPNSEHINRLKMFKNVLERIINFLQVPKANCLFYKDKMAGFEKQITNILNTNRPKKPVPSQLQGQQQSHPPGVLPNSMHQQLQTHIPQLQQQPQISQLQQQHDPQIQPINLQGSVTSMQSTAVTSMPHGSLPPSSTHLPNVRPNVMNSLQSSSNLESGQGNASSSLQQGAAGSLQESTVSMSQQSNISTLSHGSVNALQPNIGPIQPNANMLQQQHLKQQQEQQVMPSQQLKQQFQQRSMHTQLIQQQKQLMLQQQQQQHHLQLQQKFQQQQQQPPLHQQKQQPAQLQAHQMPQLHHMNEVGDLKGRQGMGAKSGNFQPHNSASQYPAYNHQPLKTGATFPTSSPQLLQASSPQISQHSSPQIDQKSLLTSLPKAGTPLQSANSPFVVPSPSPPLVPSPIPGDSEIQASTVASLSNAGNVGHPQTAVTLASAQSLAIGTPGISASPLLAEITSPDGNQGTSSIMISGKSSVIKQPLERLINVVKSVSPKVLSASVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKSRLQARNLISQDGSSATKKMRRYTSAMPLNIVSPDGSINDSFNQMNGLETSDLESTATSRIKKPRVEASHALLKEIDEINQQLIDTVVDVSDEDVEPTAGVAVESGEGTVVKCSFSAVALSPNVKSQYASAQMSPILPLRLLVPTNYPNCSPILLDRLPVELSKENDDLSLKAKSRFRISLRSLSHPMSLGDMAKTWDVCARAVVLEYAQKSGGRSFSSRYGTWESCVNAT
Length1410
PositionTail
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.03
Grand average of hydropathy-0.706
Instability index79.07
Isoelectric point9.47
Molecular weight154887.23
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12691
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     455.83|      56|      56|     352|     407|       1
---------------------------------------------------------------------------
  243-  283 (60.63/10.03)	QN....SQQY.IY..PQKQLQQ......QIL..........KPKIQ.QGN.IQQQSLM.......QQHIQQ.............QQ
  286-  345 (57.77/ 9.17)	QQ....RQQN.LLqpTQLQSSQ......QSLMQvssglpsSQSSLQH.....TQPSVMQSAP...HSVL.Q.QN.....QQTSIQS
  352-  407 (109.21/24.57)	QQ....HQQS.VL..GQQQQSQ......QSLHQ.......QPPVLQHQTP.LSQQTLLSSQQ...QQLIGQ.QP.....NATNMQQ
  413-  460 (60.97/10.13)	QQnsvpHVQ.......KTQQQQ......QT.QP.......QPP.LQQQQQ.QQQQ.....QQ...QRLLSQ.QN.....NLSNMQ.
  518-  569 (55.53/ 8.50)	TQ....GQQSqSQ..PQQQQMM......SHLPT.......QPGQLQQQLG.LQQQS..NSLQrdmQQRI.Q.TS.....SA.....
  704-  769 (57.41/ 9.07)	KK....PVPS.QL..QGQQQSHppgvlpNSMHQ.......Q...LQTHIPqLQQQPQISQLQ...QQHDPQiQPinlqgSVTSMQS
  816-  863 (54.31/ 8.14)	.......QQG.AA..GSLQEST......VSMSQ.......QSNI....ST.LSHGSV.NALQ...PNIGPI.QP.....NANMLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.65|      16|      16|    1313|    1328|       5
---------------------------------------------------------------------------
 1313- 1328 (30.58/21.03)	SPILPLRLLVPTNYPN
 1330- 1345 (28.08/18.61)	SPILLDRLPVELSKEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.38|      20|      56|     870|     889|       6
---------------------------------------------------------------------------
  472-  491 (26.83/ 6.99)	QQQQLLSPQ.SSVSNMQPNRH
  870-  889 (36.75/13.51)	QEQQVMPSQ.QLKQQFQQRSM
  890-  909 (27.59/ 7.49)	HTQLIQQQK.QLMLQQQQQQH
  929-  947 (26.21/ 6.59)	QKQQ..PAQlQAHQMPQLHHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.75|      14|     109|    1092|    1105|       7
---------------------------------------------------------------------------
 1037- 1051 (20.40/ 6.81)	VPSPSPPLVPSPiPG
 1092- 1105 (24.35/ 9.66)	SASPLLAEITSP.DG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.89|      18|      19|     176|     194|       9
---------------------------------------------------------------------------
  178-  198 (23.86/ 9.68)	LTQNtIPNASGQSSNMPnvSG
  790-  807 (25.04/ 7.15)	VRPN.VMNSLQSSSNLE..SG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.78|      17|      17|     613|     629|      11
---------------------------------------------------------------------------
  613-  629 (29.74/15.91)	EEVYEKI..KAMKEMYLPE
  631-  649 (25.04/12.19)	NEMYQKIalKCHQNDSLPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.88|      15|      19|    1057|    1072|      12
---------------------------------------------------------------------------
 1057- 1072 (22.22/17.04)	ASTVASlSNAGNVGHP
 1075- 1089 (24.66/13.96)	AVTLAS.AQSLAIGTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.32|      37|      43|    1191|    1233|      15
---------------------------------------------------------------------------
 1144- 1185 (42.20/22.94)	..VSDIGSVVSMIDRIAG...SAPG.NGSRAavgedlvamTKS..RLQAR
 1186- 1205 (28.86/ 9.98)	NLIS.....................qDGSSA.........TKKMRRYTSA
 1209- 1244 (39.26/33.92)	NIVSPDGSINDSFNQMNGletSDLEsTATSR.........IKKPR.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.57|      15|     462|     663|     677|      17
---------------------------------------------------------------------------
  663-  677 (26.65/14.41)	KNVLERIINFLQ..VPK
 1122- 1138 (21.91/10.71)	KQPLERLINVVKsvSPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.28|      16|     256|     773|     788|      20
---------------------------------------------------------------------------
  773-  788 (31.03/13.51)	TSMPHGSLPPSSTHLP
 1019- 1034 (24.25/ 8.81)	TSLPKAGTPLQSANSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12691 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLSSQQQQLIGQQPNATNMQQNQLVAQQNSVPHVQKTQQQQQTQPQPPLQQQQQQQQQ
2) LPSVQSSVSGLTQNTIPNASGQSSNMPNVSGISQNPVSNPLAQGVPSSVFPTSQRQMPGRQLQQQVIPQQ
3) MDNNNWRPAQGEPALPTMSTMDNTDWRAQLPLDA
4) METKSQPNIVPNSLPSNSAGGNPNPVDPASQSMQSQVHNQGMSLPISMPNQARQHMLPQTIQNNILPSGVQNSV
5) PLQSANSPFVVPSPSPPLVPSPIPGDSEIQASTVASLSNAGNV
6) QITNILNTNRPKKPVPSQLQGQQQSHPPGVLPNSMHQQLQTHIPQLQQQPQISQLQQQHDPQIQPINLQGSVTSMQSTAVTSMPHGSLPPSSTHLPNVRPNVMNSLQSSSNLESGQGNASSSLQQGAAGSLQESTVSMSQQSNISTLSHGSVNALQPNIGPIQPNANMLQQQHLKQQQEQQVMPSQQLKQQFQQRSMHTQLIQQQKQLMLQQQQQQHHLQLQQKFQQQQQQPPLHQQKQQPAQLQAHQMPQLHHMNEVGDLKGRQGMGAKSGNFQPHNSASQYPAYNHQPLKTGATFPTSSPQLLQASSPQISQHSSPQIDQKSLLTSLPKAG
7) QQTSLTVLPTQGQQSQSQPQQQQMMSHLPTQPGQLQQQLGLQQQSNSLQRDMQQRIQTSSALPHSQNAIEPPKQLFQSQRMLPEASSTSIDSAAQPGHANADLQEE
8) QSLMQVSSGLPSSQSSLQHTQPSVMQSAPHSVLQQNQQT
9) YVPGLQQQQLLSPQSSVSNMQPNRHSVNMLQQVKL
387
168
1
93
1027
693
509
303
467
444
237
34
166
1069
1025
614
341
501










Molecular Recognition Features






MoRF SequenceStartStop




NANANA