<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12688

Description mediator of RNA polymerase II transcription subunit 12 isoform X4
SequenceMQRYSATSSGDGVSSGTVGGSARDTARVDSSFSSSNFSLSSRRPSQLTSYKLKCDKEPLNCRLGPPDFYPQFPNCPEETLTREYVQYGYKETIEGLEEAREILLSQLITFSKPVALKCKEAIRKRLRAINESRAQKHKAGQVYGVPLSGSLLLKPGAFPEQKPCGEDSRKKWIEGLSQQHKCLHFLADNVPHGFRRKDLFEVLIRHNIPLLRATWFIKVSYLNQIRPLSVNVSSGTTDKTQLARTDLWTKDIVEYLQYLLDEFFSVNRDESPQILLAGSVHKGDSSLGLTESEEPSLYFKWWYMVRIIRWHHSEGLLYPSLVIDWVLNQLQDKESLETLQLLLPIIYGLIETIVLSQTYVHNLVEVAVRSIQESSSGSDLVDNSQKAYIASAMVEMLWYLIVAVPDTFVALDCFPLPLPVLSGVANRRFFLSKVSEDAEKTRNGAEELLTLYGEKRQVAHHHFLTFDYVVSSIQKRADNLVKAVSPVPQGHGVAKAVQALDKALTLGDLKRAYNFLFEDLCDGCIEEIWIAKVSPCLQSSLKWMGTVSFSFICSLFFLFEWATCDFRDFRTSLPCDLKFTGRKDFSQVYIAVLLLKMKIEDMHTSNQCKNGSTFGANNLGRDASHHDSFSGGVTGENVSIRKNKSKNLGGRIDSSDIFESPGPVHDIIVCWIDQHEVGKGEGFKRLQLLIMELICSGIFNPPAYARQLIVSGIMDRSETLVDLDRRRRHYFVLKQLPGAYMLDFLEVRIADISALEEALNVYSNERRLLLHGLLSDLTSHSRNGNDNNVNIDFQKQKNNPSSGQNAPGPLSGRNAKTKAQVAELKEAISILLHLPSSYSTLPDTRSDESQRSCKRSIWLIGKKMDVTEGTPGCKEYRRSKKQKSSEERSSYMQGFSPNPSNDEDSWWVRKVPKSIESFKVDPPLKSTKNTSRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNRISCPHHRTSIEGEASKPVDGMRATHLGDVVLIGKALKQLRLLEKRAITVWLMSLVRQLVEGSEKSAAKVGHRTGHLPPSDDKSSVRWKLSEDELSSILYLMDISSDLVSAVKFLLWLLPKVLSTPNSTHGGRSILMLPKNTESRSCEVGEAFLLSSIRRYESILVAADLIPEVLCASMVRAAAVMASNGRASGSAAFVYARNLLKKYGNMVSVEKWEKNFKATSDQRLLVELESGRSLDENLGFSLGVPAGVDDLDDYFRQKLSGRLTRPIPSMKEMVQKHVDEAMHSFFGKERKLFAAGTPKGPVIEKCDDGYRIAQQIVLGLIECTRQNSSTSQEVDPFIVASAVSAIVANVGPALAKMPDFTASGNYQSFPSPITSLNCARHILRIHIACLSLLKEAIGERQSRVFEIALSIEASSAVAAALAPGKGSRSQFQLSPEAHDSSTNLSNEMLTNYTKVFIGRATKAAAAVSALVIGAVVHGAASLERMVSALRLKEGLDILQFVRSAKSSSNGISRSVSAFKVDNSIEVYLHWFRLLVGNYRTVSDGLIVELLGEPYILALSRMQRMLPLSLVLPPAYSIFALMLWRPYVLNSNTITHDVQLNQSLASAIGEAITHQPFRDVCLRDTCAFYDLLASDVANSEFVAMLEMHGADKHMKTMAFVPLRARLFLNAILDCKIPQSMISQDDGVQVSGSAESKLQHTKSEIKLQDQLVHVLDTLQPAKFHWQWVELRLLLNEQALIEKIDTHNMSFVEAIRSLFPNSDNSVLSENENNFNEIILTRLLVRPDASPLYSEVVHLLGKSLEESLLLHAKWFLAGHDVLFGRKSIRQRLINVAQLRGLSTKIQFWKPWGWPHSAADLAASKGERKKFEVSSLEEGEVVEEGIDFKRLGRVTTQILDAEVFNSSQQYATERALIELVLPCIDRSSSWSSSFWD
Length1902
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.08
Grand average of hydropathy-0.192
Instability index48.37
Isoelectric point8.42
Molecular weight212215.45
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12688
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.74|      29|     270|    1152|    1221|       1
---------------------------------------------------------------------------
 1168- 1197 (44.53/76.03)	RNLLKKYGNMVSVEKwEKNFKATSDQRLLV
 1724- 1752 (49.20/ 9.37)	RSLFPNSDNSVLSEN.ENNFNEIILTRLLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.42|      53|     270|     829|     890|       2
---------------------------------------------------------------------------
  829-  890 (67.94/70.84)	SILLhLPSSystlPDTRSDESQR.....SCKR..SIwLIGKKMdVTEGTpgCKEYRRSKKQKSSEERSS
 1100- 1159 (78.48/47.30)	SILM.LPKN....TESRSCEVGEafllsSIRRyeSI.LVAADL.IPEVL..CASMVRAAAVMASNGRAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     295.55|      98|     270|      44|     190|       3
---------------------------------------------------------------------------
   44-  150 (154.49/117.66)	PSQLTSYKLK..CDKEPLNC.RLGPPDFYPQFPNCpeeTLTREYVQYGYKETIEGLEEAREilLSQLITFSKP..VALKCKEAIRKRLRAINESRAqkhkAGQVYGVP...LSGS
  319-  424 (141.06/10.79)	PSLVIDWVLNqlQDKESLETlQLLLPIIYGLIETI...VLSQTYVHNLVEVAVRSIQESSS..GSDLVDNSQKayIASAMVEMLWYLIVAVPDTFV....ALDCFPLPlpvLSGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.90|      22|      40|     655|     676|       4
---------------------------------------------------------------------------
  655-  676 (44.26/31.77)	SDIFESPGPVHDIIVCWI.DQHE
  696-  718 (35.64/23.96)	SGIFNPPAYARQLIVSGImDRSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.97|      28|    1478|     269|     304|       8
---------------------------------------------------------------------------
  269-  302 (43.03/41.75)	DESPqiLLAGSVHKGDSSLglteSEEPSLYFKWW
 1755- 1782 (49.94/24.72)	DASP..LYSEVVHLLGKSL....EESLLLHAKWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.50|      57|     584|    1229|    1287|      10
---------------------------------------------------------------------------
 1229- 1287 (88.72/66.89)	KLSGrLTRPIPSMKEMVQKHVDEAMHSFFGKERKLFAAGTPKGPVIEKCDD....GyRIAQQI
 1804- 1864 (94.78/61.58)	QLRG.LSTKIQFWKPWGWPHSAADLAASKGERKKFEVSSLEEGEVVEEGIDfkrlG.RVTTQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.71|      30|      40|     493|     522|      11
---------------------------------------------------------------------------
  493-  522 (51.16/30.66)	VAKAVQALDKALT.LGDLKRAYN....FLFE.DLCD
  530-  565 (39.55/22.10)	IAKVSPCLQSSLKwMGTVSFSFIcslfFLFEwATCD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.64|      20|     468|    1076|    1096|      14
---------------------------------------------------------------------------
 1076- 1096 (31.99/23.09)	SAVKFLLWlLPKVLSTPNSTH
 1547- 1566 (37.64/22.87)	SIFALMLW.RPYVLNSNTITH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12688 with Med12 domain of Kingdom Viridiplantae
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