<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12686

Description cyclin-dependent kinase E-1 isoform X2
SequenceMSAGSGNSSMSSRGSIGSSTHNNATATANSSSGSNSNSNKPAWLQQYDLIGKIGEGTYGLVFLARTKSNPNRGKCIAIKKFKQSKDGDGVSPTAIREIMLLREINHENVVKLVNVHINHADMSLYLAFDYAEHDLYEIIRHHREKVNHSINQYTIKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGEGEEQGVVKIADFGLARIYQAPLKPLSENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGAEVKATPNPFQLDQLDKIFKVLGHPTQEKWPTLVNLPHWQSDQQHIQGRKYDNPGLYSVVHLSQKSPPYDLLSKMLEYDPRKRITAAQALEHEYFRIDPLPGRNALVPGQPGEKVVNYPARPVDTSTDFEGTATVQPSQPVSSGNAVSGSVAAAPVVAARSVPRPMPMVGMQQRVQPPPGMTAFNLASQAGMGGGMNPGSSIPMRAAAAQAHQQQQLRRKDAGMGMPGYPPPQKRRY
Length499
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.406
Instability index42.33
Isoelectric point9.43
Molecular weight54858.91
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12686
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.84|      32|      38|     366|     399|       1
---------------------------------------------------------------------------
  366-  399 (52.05/39.45)	NALVPGQPGEKVVnyPARPVDTSTDFEG.TATVQP
  407-  439 (51.78/32.11)	NAVSGSVAAAPVV..AARSVPRPMPMVGmQQRVQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.59|      11|      29|     452|     465|       4
---------------------------------------------------------------------------
  452-  465 (15.40/15.25)	AGMggGMnPGSSIP
  484-  494 (27.19/12.58)	AGM..GM.PGYPPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12686 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPGRNALVPGQPGEKVVNYPARPVDTSTDFEGTATVQPSQPVSSGNAVSGS
2) MSAGSGNSSMSSRGSIGSSTHNNATATANSSSGSNSN
3) SVPRPMPMVGMQQRVQPPPGMTAFNLASQAGMGGGMNPGSSIPMRAAAAQAHQQQQLRRKDAGMGMPGYPPPQKRRY
362
1
423
412
37
499










Molecular Recognition Features






MoRF SequenceStartStop




1) KCIAIKKF
2) MRAAAAQAHQQQQLRRKDAGMGMPGYPPPQKRRY
74
466
81
499