<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12685

Description mediator of RNA polymerase II transcription subunit 8 isoform X3
SequenceMEGAQDQQQQQPPRVAEGLNPAVQQQLNLESVKTRAISLFKAISRILEDFDAIARTNAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVASQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFADSSGTYLKNTPPFSSSNVNSQGALLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
Length510
PositionHead
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.625
Instability index59.92
Isoelectric point9.16
Molecular weight55962.28
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12685
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     395.06|     128|     150|     204|     352|       1
---------------------------------------------------------------------------
  204-  352 (196.44/98.68)	GEGlRVPGD.QRHITSALpghlvdvltitdGPQSFAD...SSGTYLKNtppFSSSNVNsQGALLQASgvLRAAASPSGTTSFDTTTASPLPHV....NSPR..SSANM......MNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQrqKIMQL...PQ.H...QQQLLAQQQ
  360-  510 (198.62/70.86)	GLG.QLHGQpQMQFSQPL............GAQQFQGrqlASGAIHHG...MGQSQLN.QGNQLNRH..LNQFSSPMNTALFNSAQSTPNSQMfgisGGTRnlAAANLsdqmfnMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQ..GMMPLqntPQtHpsfQQQRPQGQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.80|      58|      64|      64|     127|       3
---------------------------------------------------------------------------
   70-  127 (93.84/73.88)	SMVNLELFNIVEDIK....KVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAK.REQ
  131-  193 (84.97/53.19)	SMQNLSVASQIEKLKvridMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKiQEQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12685 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
262
510










Molecular Recognition Features






MoRF SequenceStartStop




NANANA