<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12683

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMQRYSATSSGDGVSSGTVGGSARDTARVDSSFSSSNFSLSSRRPSQLTSYKLKCDKEPLNCRLGPPDFYPQFPNCPEETLTREYVQYGYKETIEGLEEAREILLSQLITFSKPVALKCKEAIRKRLRAINESRAQKHKAGQVYGVPLSGSLLLKPGAFPEQKPCGEDSRKKWIEGLSQQHKCLHFLADNVPHGFRRKDLFEVLIRHNIPLLRATWFIKVSYLNQIRPLSVNVSSGTTDKTQLARTDLWTKDIVEYLQYLLDEFFSVNRDESPQILLAGSVHKGDSSLGLTESEEPSLYFKWWYMVRIIRWHHSEGLLYPSLVIDWVLNQLQDKESLETLQLLLPIIYGLIETIVLSQTYVHNLVEVAVRSIQESSSGSDLVDNSQKAYIASAMVEMLWYLIVAVPDTFVALDCFPLPLPVLSGVANRRFFLSKVSEDAEKTRNGAEELLTLYGEKRQVAHHHFLTFDYVVSSIQKRADNLVKAVSPVPQGHGVAKAVQALDKALTLGDLKRAYNFLFEDLCDGCIEEIWIAKVSPCLQSSLKWMGTVSFSFICSLFFLFEWATCDFRDFRTSLPCDLKFTGRKDFSQVYIAVLLLKMKIEDMHTSNQCKNGSTFGANNLGRDASHHDSFSGGVTGENVSIRKNKSKNLGGRIDSSDIFESPGPVHDIIVCWIDQHEVGKGEGFKRLQLLIMELICSGIFNPPAYARQLIVSGIMDRSETLVDLDRRRRHYFVLKQLPGAYMLDFLEVRIADISALEEALNVYSNERRLLLHGLLSDLTSHSRNGNDNNVNIDFQKQKNNPSSGQNAPGPLSGRNAKTKAQVAELKEAISILLHLPSSYSTLPDTRSDESQRSCKRSIWLIGKKMDVTEGTPGCKEYRRSKKQKSSEERSSYMQGFSPNPSNDEDSWWVRKVPKSIESFKVDPPLKSTKNTSRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNRISCPHHRTSIEGEASKPVDGMRATHLGDVVLIGKALKQLRLLEKRAITVWLMSLVRQLVEGSEKSAAKVGHRTGHLPPSDDKSSVRWKLSEDELSSILYLMDISSDLVSAVKFLLWLLPKVLSTPNSTHGGRSILMLPKNTESRSCEVGEAFLLSSIRRYESILVAADLIPEVLCASMVRAAAVMASNGRASGSAAFVYARNLLKKYGNMVSVEKWEKNFKATSDQRLLVELESGRSLDENLGFSLGVPAGVDDLDDYFRQKLSGRLTRPIPSMKEMVQKHVDEAMHSFFGKERKLFAAGTPKGPVIEKCDDGYRIAQQIVLGLIECTRQNSSTSQEVDPFIVASAVSAIVANVGPALAKMPDFTASGNYQSFPSPITSLNCARHILRIHIACLSLLKEAIGERQSRVFEIALSIEASSAVAAALAPGKGSRSQFQLSPEAHDSSTNLSNEMLTNYTKVFIGRATKAAAAVSALVIGAVVHGAASLERMVSALRLKEGLDILQFVRSAKSSSNGISRSVSAFKVDNSIEVYLHWFRLLVGNYRTVSDGLIVELLGEPYILALSRMQRMLPLSLVLPPAYSIFALMLWRPYVLNSNTITHDVQLNQSLASAIGEAITHQPFRDVCLRDTCAFYDLLASDVANSEFVAMLEMHGADKHMKTMAFVPLRARLFLNAILDCKIPQSMISQDDGVQVSGSAESKLQHTKSEIKLQDQLVHVLDTLQPAKFHWQWVELRLLLNEQALIEKIDTHNMSFVEAIRSLFPNSDNSVLSENENNFNEIILTRLLVRPDASPLYSEVVHLLGKSLEESLLLHAKWFLAGHDVLFGRKSIRQRLINVAQLRGLSTKIQFWKPWGWPHSAADLAASKGERKKFEVSSLEEGEVVEEGIDFKRLGRVTTQILDAEVFNSSQQYATERALIELVLPCIDRSSSESRNTFANELIKQMNNIEQQINAVTHGINKQAGAVPSGIEGSTSKSSSRKGTRHGSPGLGRRLIGLSDSAPPSSAALRASMWLRLQFLLRFLPLIYADRELSSRNMRQMLASIILRLLGSRVVHEDADLSYQIQSSPSKREVESPMEPAVIASLDLSGDSLFDRFLSILHGLLSSCKPRWLKPKSASKSTVKSPRDFSVFDREAAESLQNDLDHMQLPETIRWRLQAAMPMPPPPSFSITCQPPTISSAAIASLQSPVFQHGNSNLPQKNLLPSSRAPASILGKLKQSQTQDQVMEVDPWTLLEDGSGLGSSLNNNSGVGATGDHANLKACNWLKGAVRVRRTDLTYIGAVDDR
Length2249
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.217
Instability index51.02
Isoelectric point8.69
Molecular weight249914.97
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12683
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     616.41|     204|     991|    1007|    1220|       1
---------------------------------------------------------------------------
 1007- 1220 (308.22/239.67)	RLLEKRAITVWLMSLVRQLVeGSE..KSAAKVGHRTGHLP.......PSDDKSSVRWKLSEDELSSilYLMDISSDLVSAVKfLLWLLPKVlSTPNSTHGGRSILMLPKN.TESRSCEVGEAFLLSSIR.RYESilvAADLIP....EVLC.ASMVRAAAV..MASNGRASGSAAfVYARNLLKKYGNMVSVEKWEKNfKATSDQRLLVE....LESGRSLDENLGFSLGVPAGVD
 1994- 2219 (308.19/204.86)	RELSSRNMRQMLASIILRLL.GSRvvHEDADLSYQIQSSPskrevesPMEPAVIASLDLSGDSLFD..RFLSILHGLLSSCK.PRWLKPKS.ASKSTVKSPRDFSVFDREaAESLQNDLDHMQLPETIRwRLQA...AMPMPPppsfSITCqPPTISSAAIasLQSPVFQHGNSN.LPQKNLLPSSRAPASILGKLKQ.SQTQDQVMEVDpwtlLEDGSGLGSSLNNNSGVGATGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     267.56|      87|     140|     188|     278|       2
---------------------------------------------------------------------------
  188-  278 (141.40/117.02)	DNVPHGFRRKDLFEVLiRHNIPL...LRATWFIKVSYLNQIRPLSV....NVSSGT..TDKTQLArtdLWTKDIVEYLQYLL....DEFFSVNRDESPQILLAG
  324-  423 (126.17/91.49)	DWVLNQLQDKESLETL.QLLLPIiygLIETIVLSQTYVHNLVEVAVrsiqESSSGSdlVDNSQKA...YIASAMVEMLWYLIvavpDTFVALDCFPLPLPVLSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.90|      22|      40|     655|     676|       3
---------------------------------------------------------------------------
  655-  676 (44.26/28.19)	SDIFESPGPVHDIIVCWI.DQHE
  696-  718 (35.64/21.18)	SGIFNPPAYARQLIVSGImDRSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.79|      29|    1509|     122|     150|       4
---------------------------------------------------------------------------
  122-  150 (50.01/35.24)	IRKR..LRAINESRAQKHKAGQVYGVPLSGS
 1632- 1662 (45.78/31.54)	LRARlfLNAILDCKIPQSMISQDDGVQVSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.05|      26|      40|     493|     518|       6
---------------------------------------------------------------------------
  493-  518 (42.53/29.70)	VAKAVQALDKALT.LGDLKRAYN....FLFE
  530-  560 (35.52/23.40)	IAKVSPCLQSSLKwMGTVSFSFIcslfFLFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12683 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGAVPSGIEGSTSKSSSRKGTRHGSPGLGRRLI
2) GNDNNVNIDFQKQKNNPSSGQNAPGPLSGRNAKTK
3) GTPGCKEYRRSKKQKSSEERSSYMQGFSPNP
1927
784
869
1959
818
899










Molecular Recognition Features






MoRF SequenceStartStop




1) WVRKV
907
911