<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12683

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMQRYSATSSGDGVSSGTVGGSARDTARVDSSFSSSNFSLSSRRPSQLTSYKLKCDKEPLNCRLGPPDFYPQFPNCPEETLTREYVQYGYKETIEGLEEAREILLSQLITFSKPVALKCKEAIRKRLRAINESRAQKHKAGQVYGVPLSGSLLLKPGAFPEQKPCGEDSRKKWIEGLSQQHKCLHFLADNVPHGFRRKDLFEVLIRHNIPLLRATWFIKVSYLNQIRPLSVNVSSGTTDKTQLARTDLWTKDIVEYLQYLLDEFFSVNRDESPQILLAGSVHKGDSSLGLTESEEPSLYFKWWYMVRIIRWHHSEGLLYPSLVIDWVLNQLQDKESLETLQLLLPIIYGLIETIVLSQTYVHNLVEVAVRSIQESSSGSDLVDNSQKAYIASAMVEMLWYLIVAVPDTFVALDCFPLPLPVLSGVANRRFFLSKVSEDAEKTRNGAEELLTLYGEKRQVAHHHFLTFDYVVSSIQKRADNLVKAVSPVPQGHGVAKAVQALDKALTLGDLKRAYNFLFEDLCDGCIEEIWIAKVSPCLQSSLKWMGTVSFSFICSLFFLFEWATCDFRDFRTSLPCDLKFTGRKDFSQVYIAVLLLKMKIEDMHTSNQCKNGSTFGANNLGRDASHHDSFSGGVTGENVSIRKNKSKNLGGRIDSSDIFESPGPVHDIIVCWIDQHEVGKGEGFKRLQLLIMELICSGIFNPPAYARQLIVSGIMDRSETLVDLDRRRRHYFVLKQLPGAYMLDFLEVRIADISALEEALNVYSNERRLLLHGLLSDLTSHSRNGNDNNVNIDFQKQKNNPSSGQNAPGPLSGRNAKTKAQVAELKEAISILLHLPSSYSTLPDTRSDESQRSCKRSIWLIGKKMDVTEGTPGCKEYRRSKKQKSSEERSSYMQGFSPNPSNDEDSWWVRKVPKSIESFKVDPPLKSTKNTSRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNRISCPHHRTSIEGEASKPVDGMRATHLGDVVLIGKALKQLRLLEKRAITVWLMSLVRQLVEGSEKSAAKVGHRTGHLPPSDDKSSVRWKLSEDELSSILYLMDISSDLVSAVKFLLWLLPKVLSTPNSTHGGRSILMLPKNTESRSCEVGEAFLLSSIRRYESILVAADLIPEVLCASMVRAAAVMASNGRASGSAAFVYARNLLKKYGNMVSVEKWEKNFKATSDQRLLVELESGRSLDENLGFSLGVPAGVDDLDDYFRQKLSGRLTRPIPSMKEMVQKHVDEAMHSFFGKERKLFAAGTPKGPVIEKCDDGYRIAQQIVLGLIECTRQNSSTSQEVDPFIVASAVSAIVANVGPALAKMPDFTASGNYQSFPSPITSLNCARHILRIHIACLSLLKEAIGERQSRVFEIALSIEASSAVAAALAPGKGSRSQFQLSPEAHDSSTNLSNEMLTNYTKVFIGRATKAAAAVSALVIGAVVHGAASLERMVSALRLKEGLDILQFVRSAKSSSNGISRSVSAFKVDNSIEVYLHWFRLLVGNYRTVSDGLIVELLGEPYILALSRMQRMLPLSLVLPPAYSIFALMLWRPYVLNSNTITHDVQLNQSLASAIGEAITHQPFRDVCLRDTCAFYDLLASDVANSEFVAMLEMHGADKHMKTMAFVPLRARLFLNAILDCKIPQSMISQDDGVQVSGSAESKLQHTKSEIKLQDQLVHVLDTLQPAKFHWQWVELRLLLNEQALIEKIDTHNMSFVEAIRSLFPNSDNSVLSENENNFNEIILTRLLVRPDASPLYSEVVHLLGKSLEESLLLHAKWFLAGHDVLFGRKSIRQRLINVAQLRGLSTKIQFWKPWGWPHSAADLAASKGERKKFEVSSLEEGEVVEEGIDFKRLGRVTTQILDAEVFNSSQQYATERALIELVLPCIDRSSSESRNTFANELIKQMNNIEQQINAVTHGINKQAGAVPSGIEGSTSKSSSRKGTRHGSPGLGRRLIGLSDSAPPSSAALRASMWLRLQFLLRFLPLIYADRELSSRNMRQMLASIILRLLGSRVVHEDADLSYQIQSSPSKREVESPMEPAVIASLDLSGDSLFDRFLSILHGLLSSCKPRWLKPKSASKSTVKSPRDFSVFDREAAESLQNDLDHMQLPETIRWRLQAAMPMPPPPSFSITCQPPTISSAAIASLQSPVFQHGNSNLPQKNLLPSSRAPASILGKLKQSQTQDQVMEVDPWTLLEDGSGLGSSLNNNSGVGATGDHANLKACNWLKGAVRVRRTDLTYIGAVDDR
Length2249
PositionKinase
OrganismNelumbo nucifera (Sacred lotus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Proteales> Nelumbonaceae> Nelumbo.
Aromaticity0.07
Grand average of hydropathy-0.217
Instability index51.02
Isoelectric point8.69
Molecular weight249914.97
Publications
PubMed=23663246

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12683
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     616.41|     204|     991|    1007|    1220|       1
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 1007- 1220 (308.22/239.67)	RLLEKRAITVWLMSLVRQLVeGSE..KSAAKVGHRTGHLP.......PSDDKSSVRWKLSEDELSSilYLMDISSDLVSAVKfLLWLLPKVlSTPNSTHGGRSILMLPKN.TESRSCEVGEAFLLSSIR.RYESilvAADLIP....EVLC.ASMVRAAAV..MASNGRASGSAAfVYARNLLKKYGNMVSVEKWEKNfKATSDQRLLVE....LESGRSLDENLGFSLGVPAGVD
 1994- 2219 (308.19/204.86)	RELSSRNMRQMLASIILRLL.GSRvvHEDADLSYQIQSSPskrevesPMEPAVIASLDLSGDSLFD..RFLSILHGLLSSCK.PRWLKPKS.ASKSTVKSPRDFSVFDREaAESLQNDLDHMQLPETIRwRLQA...AMPMPPppsfSITCqPPTISSAAIasLQSPVFQHGNSN.LPQKNLLPSSRAPASILGKLKQ.SQTQDQVMEVDpwtlLEDGSGLGSSLNNNSGVGATGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     267.56|      87|     140|     188|     278|       2
---------------------------------------------------------------------------
  188-  278 (141.40/117.02)	DNVPHGFRRKDLFEVLiRHNIPL...LRATWFIKVSYLNQIRPLSV....NVSSGT..TDKTQLArtdLWTKDIVEYLQYLL....DEFFSVNRDESPQILLAG
  324-  423 (126.17/91.49)	DWVLNQLQDKESLETL.QLLLPIiygLIETIVLSQTYVHNLVEVAVrsiqESSSGSdlVDNSQKA...YIASAMVEMLWYLIvavpDTFVALDCFPLPLPVLSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.90|      22|      40|     655|     676|       3
---------------------------------------------------------------------------
  655-  676 (44.26/28.19)	SDIFESPGPVHDIIVCWI.DQHE
  696-  718 (35.64/21.18)	SGIFNPPAYARQLIVSGImDRSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.79|      29|    1509|     122|     150|       4
---------------------------------------------------------------------------
  122-  150 (50.01/35.24)	IRKR..LRAINESRAQKHKAGQVYGVPLSGS
 1632- 1662 (45.78/31.54)	LRARlfLNAILDCKIPQSMISQDDGVQVSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.05|      26|      40|     493|     518|       6
---------------------------------------------------------------------------
  493-  518 (42.53/29.70)	VAKAVQALDKALT.LGDLKRAYN....FLFE
  530-  560 (35.52/23.40)	IAKVSPCLQSSLKwMGTVSFSFIcslfFLFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12683 with Med12 domain of Kingdom Viridiplantae
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