<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12681

Description mediator of RNA polymerase II transcription subunit 8 isoform X2
SequenceMEGAQDQQQQQPPRVAEGLNPAVQQQLNLESVKTRAISLFKAISRILEDFDAIARTNAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVASQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFADSSGTYLKNTPPFSSSNVNSQGALLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
Length524
PositionHead
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.605
Instability index59.82
Isoelectric point9.32
Molecular weight57519.15
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12681
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     304.09|      71|     164|     247|     318|       4
---------------------------------------------------------------------------
  247-  318 (125.29/46.28)	NTPP.....................FSSSNVNSQ..GALLQASGVLR..AAASPSGTTSFDTTTASPLPHVNSPRSSaNMMNTPS..PQQQSLQQQQQQ
  368-  447 (64.56/19.62)	FSQPlgaqqfqgrqlasgaihhgmgQSQLNQGNQlnRHLNQFS.........SPMNTALFNSAQSTPNSQMISNMSA..MMTSQTllPRTQ........
  451-  483 (44.26/11.50)	..........................................SGGTRnlAAANLSDQM.FNMGGNNP...........GMM..P........IQQ..QQ
  484-  521 (69.98/21.79)	QHGT.....................FGNMSQNTQ..N..LQQ.GMM......................P..........LQNTPQ...THPSFQQQRPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     180.84|      61|      64|      70|     132|       5
---------------------------------------------------------------------------
   44-   84 (27.80/18.01)	..........................SRILEDFDaiARTNAvpK...WQDILGQFSmvNLELFNIVEDIK
   85-  145 (95.70/58.30)	KVSKAFVVHPKNVNAENAAILPVMLSSKLLPEME..VEDNA..K...REQLLHSMQ..NLSVASQIEKLK
  150-  198 (57.34/31.71)	MIGAACESAEKVIADTRKAYFGTRQGPTLLPTID..KAQAA..KiqeQESLLR.................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12681 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
262
524










Molecular Recognition Features






MoRF SequenceStartStop




1) HPSFQQ
512
517