<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12672

Description mediator of RNA polymerase II transcription subunit 8 isoform X4
SequenceMEGAQDQQQQQPPRVAEGLNPAVQQQLNLESVKTRAISLFKAISRILEDFDAIARTNAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVASQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFADSSGTYLKNTPPFSSSNVNSQGALLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQCSIWAETILV
Length461
PositionHead
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.489
Instability index57.64
Isoelectric point8.83
Molecular weight50629.69
Publications
PubMed=23773524

Function

Annotated function 
ECO:0000256	RuleBase:RU364057
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP12672
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.32|      46|     308|       5|      71|       1
---------------------------------------------------------------------------
    5-   71 (66.75/47.41)	QDQQQQQPPRVAEGLN........PAVQQQLnLESVKTRAISLfkaisriledfdaiartnavPKWQDILGQFSM
  317-  370 (78.56/28.82)	QQQQQQQQLQQQQQLQqrqkimqlPQHQQQL.LAQQQLRQASM....................PGLGQLHGQPQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.10|      12|      18|     376|     392|       2
---------------------------------------------------------------------------
  382-  400 ( 7.05/13.74)	QGRQLASgaiHhgMgqSQL
  402-  413 (24.05/11.78)	QGNQLNR...H..L..NQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.27|      17|      18|     415|     432|       3
---------------------------------------------------------------------------
  415-  432 (26.00/16.79)	SPMnTALFNSAQSTPNSQ
  435-  451 (30.27/15.30)	SNM.SAMMTSQTLLPRTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.75|      14|      18|     274|     288|       4
---------------------------------------------------------------------------
  274-  288 (20.77/14.67)	SPSGTTSFdTTTASP
  294-  307 (26.97/14.51)	SPRSSANM.MNTPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.94|      32|      64|     113|     149|       5
---------------------------------------------------------------------------
  113-  149 (48.49/38.44)	LLPEMEVEDNAK...REQLLHSMQNLSvasqiEKLKVRID
  178-  212 (49.45/29.03)	LLPTIDKAQAAKiqeQESLLRTAVNHG.....EGLRVPGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12672 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAM
262
440










Molecular Recognition Features






MoRF SequenceStartStop




NANANA