<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12669

Description mediator of RNA polymerase II transcription subunit 8 isoform X1
SequenceMEGAQDQQQQQPPRVAEGLNPAVQQQLNLESVKTRAISLFKAISRILEDFDAIARTNAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVASQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFADSSGTYLKNTPPFSSSNVNSQGALLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
Length528
PositionHead
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.606
Instability index59.24
Isoelectric point9.32
Molecular weight57954.62
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12669
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.58|      25|      27|     342|     366|       4
---------------------------------------------------------------------------
  345-  371 (43.42/15.12)	QQLLAQQ.QL......RQ.AS...MPGLGQLHGqpQMQ
  374-  404 (28.55/ 7.43)	QPLGAQQfQG......RQlASgaiHHGMGQSQL.nQGN
  500-  527 (34.61/10.56)	QNL...Q.QGmmplqnTP.QT...HPSFQQQRP..QGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.90|      16|      17|     420|     435|       5
---------------------------------------------------------------------------
  420-  433 (18.62/ 8.27)	.....ALFNSAQSTPNSQM
  434-  452 (20.55/ 9.95)	ISnmsAMMTSQTLLPRTQF
  454-  470 (19.73/ 9.24)	IS..gGTRNLAAANLSDQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.75|      14|      17|     274|     288|       7
---------------------------------------------------------------------------
  274-  288 (20.77/17.47)	SPSGTTSFdTTTASP
  294-  307 (26.97/17.27)	SPRSSANM.MNTPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.52|      35|      65|     162|     198|       9
---------------------------------------------------------------------------
  162-  198 (47.56/40.07)	IADTRKAyFGTRQGpTLLPTIDKAQAAKIQEQESLLR
  230-  264 (59.97/38.81)	ITDGPQS.FADSSG.TYLKNTPPFSSSNVNSQGALLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12669 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
262
528










Molecular Recognition Features






MoRF SequenceStartStop




NANANA