<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12667

Description cyclin-dependent kinase E-1
SequenceMGDGNTSSRGGNSNSSNRPEWLQHYDLIGKIGEGTYGLVFLAKIKANRSKSIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINQADMSLYLAFDYAEHDLYEIIRHHRDKVNQAINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEEHGVIKIADFGLARIYQAPLKPLAENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKGTPNPFQLDQLDKIFKVLGHPTPEKWPTLVNLPHWQSDVQRIQGHKYDNPALYSVLHLTPKSPAYDLLSKMLEYDPRKRITAAQALEHEYFRMEPLPGRNALVPPQPGEKIVNYPTRPVDTTTDFEGTISLQPPQPVSSGNAASGGMQGPHVMPNRSVPRPMPMVNMQRMPQGMSAYNLASQAGMGAGMNPGNMPIQRGVASQAHQQQMRRKDPGMGMPGYPPQQKSRRF
Length472
PositionKinase
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.08
Grand average of hydropathy-0.458
Instability index41.42
Isoelectric point9.35
Molecular weight52853.10
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12667
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.87|      28|      31|     410|     440|       1
---------------------------------------------------------------------------
  376-  398 (35.24/17.12)	...PQPVSSGNAAS.GGMqG....PHVMP.NR
  410-  440 (46.11/37.48)	QRMPQGMSAYNLASqAGM.GaGMnPGNMPIQR
  452-  468 (35.53/17.32)	RRKDPGM..............GM.PGYPPQQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.20|      18|      31|      77|      95|       2
---------------------------------------------------------------------------
   77-   95 (27.27/25.99)	LREITHENVVKlVNVHINQ
  111-  128 (32.92/25.72)	LYEIIRHHRDK.VNQAINQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.80|      25|      42|     300|     329|       3
---------------------------------------------------------------------------
  300-  329 (32.14/37.43)	LTPKSPAydllSKMLEYdPRKRITAAQALE
  344-  368 (45.66/32.05)	LVPPQPG....EKIVNY.PTRPVDTTTDFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.70|      18|      20|     183|     200|       5
---------------------------------------------------------------------------
  183-  200 (33.03/23.21)	YQAP..LKPLAENGVVVTIW
  201-  220 (27.68/18.24)	YRAPelLLGAKHYTSAVDMW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.28|      17|      22|     258|     276|       6
---------------------------------------------------------------------------
  258-  276 (26.99/19.56)	KVLGHPTPEkwPTLVNLPH
  283-  299 (31.30/15.52)	RIQGHKYDN..PALYSVLH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12667 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPLPGRNALVPPQPGEKIVNYPTRPVDTTTDFEGTISLQPPQPVSSGNAASGGMQGPHVMPNRSVPRPMPMVNMQRMPQGMSAYNLASQAGMGAGMNPGNMPIQRGVASQAHQQQMRRKDPGMGMPGYPPQQKSRRF
336
472










Molecular Recognition Features






MoRF SequenceStartStop




1) GMPGYPPQQKSRRF
2) KSIAIKKFK
3) QQMRRKDP
459
50
449
472
58
456