<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12666

Description mediator of RNA polymerase II transcription subunit 8 isoform X5
SequenceMLRMLQVRISSLTLVLPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVASQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFADSSGTYLKNTPPFSSSNVNSQGALLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
Length439
PositionHead
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.634
Instability index63.23
Isoelectric point9.99
Molecular weight48102.70
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12666
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.25|      17|      17|     211|     227|       1
---------------------------------------------------------------------------
  211-  227 (35.06/ 9.60)	NMMNTPSPQQQSLQQQQ
  230-  246 (28.29/ 6.42)	QQQQQQLQQQQQLQQRQ
  247-  263 (29.90/ 7.17)	KIMQLPQHQQQLLAQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.48|      31|      64|      25|      88|       3
---------------------------------------------------------------------------
   25-   60 (46.76/85.74)	LPEMEVEDNAK...REQLLHSMQNLSvasqiEKLKVRID
   90-  123 (47.72/19.18)	LPTIDKAQAAKiqeQESLLRTAVNHG.....EGLRVPGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.59|      17|      64|     342|     362|       4
---------------------------------------------------------------------------
  342-  358 (27.63/17.52)	SQMISNMSAMMTSQTLL
  366-  382 (25.96/ 6.97)	SGGTRNLAAANLSDQMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.05|      35|     120|     282|     316|       5
---------------------------------------------------------------------------
  144-  164 (26.34/ 7.13)	..............GPQ......SFADSSGTYLKNTPPFSS
  165-  193 (27.93/ 8.02)	SNVN...SQGALLQASG...vlrAAASPSGTTSFD......
  269-  299 (45.34/17.78)	...MPGLGQ..LHGQPQ.....mQFSQPLGAQQFQGRQLAS
  300-  337 (46.44/18.40)	GAIHHGMGQSQLNQGNQlnrhlnQFSSPMNTALFNSAQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.29|      11|      16|     405|     415|       6
---------------------------------------------------------------------------
  405-  415 (19.71/ 7.33)	NMSQNTQNLQQ
  422-  432 (21.58/ 8.63)	NTPQTHPSFQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12666 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLQASGVLRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQLQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLLPRTQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
173
439










Molecular Recognition Features






MoRF SequenceStartStop




NANANA