<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12647

Description ATP-dependent DNA helicase Q-like 4A isoform X3
SequenceMSKDKLPKVNWTQHATAHENFSCQDKFLTSNFLFSLPTQKPCVREQMNARSMACQVRSVTKLETEKAWKLLNSLKLSSKSYTRPGKTLPLTKENKTFSQHSHNTHVPRASDVNYASARCTPLHQGVDENSEYSDTTRYAGNRFPSHSSGVAETGNVVNRQNGADTSVGNNSHSRGIVGISSNHAIGVSKTRESDSTYADGTEEDDILQNIDIDQIVEHYQTNCTPQPSVSRCPPITPVTDSKCLAGSGETNLPPELSLNCNHGLKLGLCPEALDHLQEMKDRLINISNDLLDNVSELSLEQVEMLRQERSQLKLQIQHLEKFLQTASGNEERRMSQFSASTQTSAFQYETPRAVPSRIDPIRLDTQFHGYNESGGFGNWNSSSLSFDVTGGYGLSTAPVEREPYIPKYLDVKYTEGSNDKKWSSRDFPWTKKLEADNKKVFGNPSFRPNQREVINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMHLLQVNIPAAYLSSNMEWTEQQEILRELNSDVCKYKFLYVTPEKVAKSDVLLRHLESLHTRESLARIVIDEAHCVSQWGHDFRPDYQGLGILKQKFPTVPVLALTATATMSVKEDVVQALGLANCIIFRQSFNRPNLRYSVIPKTKKCLEDIDNFIKKFHFDQCGIIYCLSRMDCERVAEKLQEYGHKAAFYHGSMEGAQRANIQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGLPSSCVLYYSYSDYIRVKHMISQGTVDQNSFGSGYGRSNVAASGRILETNVENLLRMVSYCENDVDCRRLLQLIHFGEKFESTNCRKTCDNCSKIQKCIEKDVTEVAKQLVELVKMTGQKFSSAHVLEVYRGSLSQYVKKHRHESLRLHGAGKHLAKGEASRVLRHLVTEDILVEDVKKSDLYGSVSSVLKVNESKAYNLFSGAQTMRLRLPSSVTQSKLGKFEATPAKGSLTSGKQSPPRTDPSAVPQSPVDTNLSAKLYTALRRLRTLLVKEAGDGVMAYHIFGDATMQQISIKVPRTTDELLDINGIGKVKITKYGDRVLETIEATINEHYKSAKTNSSGNDNTDSGKKRRNSINVQNANSKDEEDFTGSTGRSKKRVLKKQNKNPEVIDYRDLGYFDECMDGDIDFDESMMP
Length1176
PositionUnknown
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.541
Instability index42.33
Isoelectric point8.32
Molecular weight131699.32
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IEA:InterPro
ATP binding	GO:0005524	IEA:UniProtKB-KW
hydrolase activity	GO:0016787	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
DNA recombination	GO:0006310	IEA:InterPro
DNA repair	GO:0006281	IEA:InterPro
DNA replication	GO:0006260	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP12647
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.48|      19|      35|     960|     978|       1
---------------------------------------------------------------------------
  960-  978 (33.83/21.14)	LFSGAQTMRLRLPSSVTQS
  992- 1010 (35.65/22.69)	LTSGKQSPPRTDPSAVPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.50|      12|      35|     222|     233|       2
---------------------------------------------------------------------------
  222-  233 (25.48/19.18)	NCTPQPSVSRCP
  259-  270 (24.02/17.55)	NCNHGLKLGLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.76|      16|      28|     134|     150|       3
---------------------------------------------------------------------------
  114-  126 (18.26/ 8.35)	....YASARCTPLHQGV
  134-  150 (27.72/23.54)	DTTrYAGNRFPSHSSGV
  164-  176 (23.78/13.92)	DTS.V.GNN..SHSRGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.73|      35|      39|     805|     842|       4
---------------------------------------------------------------------------
  805-  842 (56.97/42.67)	RileTNVENLLRMVSYCENDVD..CRRLLQLIHF.GEKFES
  846-  883 (51.76/31.43)	R...KTCDNCSKIQKCIEKDVTevAKQLVELVKMtGQKFSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.26|      11|      23|     918|     930|       5
---------------------------------------------------------------------------
  918-  930 (13.88/15.07)	GEASRVLRhlVTE
  944-  954 (18.38/10.82)	GSVSSVLK..VNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.02|      15|      39|     617|     631|       6
---------------------------------------------------------------------------
  617-  631 (25.97/19.72)	EDV...VQALGLANC.IIF
  653-  671 (19.05/12.30)	EDIdnfIKKFHFDQCgIIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.92|      18|      40|     370|     406|       7
---------------------------------------------------------------------------
  370-  389 (30.00/49.41)	YNESGGFGNWnsSSLSFDVT
  413-  430 (36.92/12.81)	YTEGSNDKKW..SSRDFPWT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.26|      42|     409|     679|     753|       8
---------------------------------------------------------------------------
  706-  753 (68.92/96.49)	NIQKQWSKDEINIICATvafgmGINKPDVrFVIHHSLPKSIE....GYHQEC
 1118- 1163 (69.34/32.38)	NVQNANSKDEEDFTGST.....GRSKKRV.LKKQNKNPEVIDyrdlGYFDEC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12647 with Med34 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQGVDENSEYSDTTRYAGNRFPSHSSGVAETGNVVNRQNGADTSVGNNSHSRGIVGISSNHAIGVSKTRESDSTYADGTEED
2) TINEHYKSAKTNSSGNDNTDSGKKRRNSINVQNANSKDEEDFTGSTGRSKKRVLKKQNK
3) YTRPGKTLPLTKENKTFSQHSHNTHVPRASDVNYASARCTP
123
1089
81
204
1147
121










Molecular Recognition Features






MoRF SequenceStartStop




1) KRVLKK
1139
1144