<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12625

Description mediator of RNA polymerase II transcription subunit 33A-like
SequenceMAAMVSSVQIQSNLWDGVMELTKSAQQKGTDPLMWAIQLSSNLNSAGLSMPSTDVANLLVSHICWANNVPIAWKFLEKALTLRVVPPMFVLALLSTRVIPARRSYPVAYRLYMELLKRYAFSLASLINGPNYQKIMEAINDTLHLYQIFGLQGSESGLIVVEFVFAIVWELLDASLDDEGLMELTAEKKSRWPITSQDMGLNNHDGFAGGRTEKHEGLCKMNTVMAIEIIGEFFRDKVTSAILYLARKNMPGHWESFTQNLRLLVSNSSALRNSKNISPEALLQLTSDNHVVLSRKRKTSSQKKFHAVVVSGSLASSADQCHGASPSVLWLPFDLFLEDTIDGSQVAATSAAETLTGLVKALQAVNSTTWQDTFLGLWIAALRLVNRERDPSEGPVPRLDTCLCLLLSITPLAIANLIEEEERNCSSTNQTKESSRKRHQDLLSTLQQLDDYEGLLTPPLPAAPLANQAAAKAMMFLSGLRVGSGYFEGMSLNDMPVNCAGNLRHLIVEACIARNILDTSAYLWPGYVKGRCDQVPRSVSGQMPGWSSLMKGSPLTPPMVSSLVSTPASSLAEIEKIYDIAVNGSDDDKISAATILCGASLARGWNIQEHTVLFITRLLSPPVSANYSGTESHLIGYARFLNVLLIGVSSIDCVQIVSLHGLVPQLAGALMPICEAFGSCAPNVTWIVMSEEISSHAIFSNAFTLLLKLWRFDQPPRENVMDVVPVGSRLTPEYLLLVRNSQLASSDDLQKDQSKIKRLSRLSSPLSGEPIFMDSFPKLKLWYRQHQACIGSPLSGLLPGTPVHQIVEALLNFMFRKINRTGQSLAPTTSGSSSSSGPGNEDVFLHLKLPAWDILEAVPFVLDAALTACAHGRLSPRELATGLKDLADFLPASLATIVSYFSAEVTRGIWKLASMNGTDWPSPAANLATVEQQIKKILAATGVNVPSLTVGGNSPATLPLPLAALVSLTITYKLDRSTDRFLNLMGPALSNLATACPWPCMPVMVALWAQKVKRWSDFLVFSASRTVFHHNSDAVVQLLRMCFAATLGLTTSSIASNGGVGALLGHGFGSHFSGGISPVAPGILYLRIHRAVRNAMFMTEEVVSLLMHFVRDIASSGLPAEKLEKLKKSKYGMRYGQVSLAAAMTRVKLAASLGASLVWITGGVALVQSLIKETLPSWFISAHGSEPSGGMSGGLVAMLGGYALAYFAVLSGTFAWGVDSSSPASKHRSIILGGHLEFLASALDGKISLGCNKATWRAYVSGFVSLMVGSTPGWMLEVDVDILKRLSMGLKQWNEEELALALLGSSGIGAMGTAAEMIIEGGFNFVR
Length1327
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy0.181
Instability index46.21
Isoelectric point7.57
Molecular weight143425.31
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12625
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.18|      12|      29|     760|     771|       1
---------------------------------------------------------------------------
  760-  771 (22.16/11.07)	SRLSSPLSGEPI
  792-  803 (23.02/11.81)	SPLSGLLPGTPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.48|      32|      34|    1184|    1217|       2
---------------------------------------------------------------------------
 1152- 1182 (21.42/ 8.03)	..SLGAS..LVWITGGVALvqsliketlpSWF...IS...A..
 1186- 1217 (59.97/44.04)	EPSGGMSGGLVAMLGGYAL..........AYFA.VLSGTFAWG
 1219- 1250 (47.08/26.08)	DSSSPASKHRSIILGGH.L..........EFLAsALDGKISLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.25|      27|      34|      51|      83|       3
---------------------------------------------------------------------------
   51-   77 (50.25/39.61)	PSTDVANLLVSHICWA.NNVPIAWK.FLE
   86-  114 (40.01/18.82)	PPMFVLALLSTRVIPArRSYPVAYRlYME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     360.70|      92|     246|     822|     913|       4
---------------------------------------------------------------------------
  822-  913 (153.14/90.71)	GQS...................LAPTTSGSSSSSGPGNEDVFLHLKL.....PAWDILEAV.....PFVLDAALTACAHGRLSP..RELATG................LKDLADFLPASLATIVSYFSAEVTRGIWKL..A
  916- 1044 (104.99/59.67)	NGTdwpspaanlatveqqikkiLAATGVNVPSLTVGGNSPATLPLPL.....AAL.VSLTI.....TYKLDRS.TDRFLNLMGPalSNLATAcpwpcmpvmvalwaqkVKRWSDFLVFSASRTVFHHNSDAVVQLLRMcfA
 1065- 1150 (102.56/58.10)	GHG...................FGSHFSGGISPVAPG....ILYLRIhravrNAMFMTEEVvsllmHFVRDIASSGLPAEKLEK.lKKSKYG................MR....YGQVSLA.......AAMTR..VKL..A
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.68|      11|      30|     338|     348|      11
---------------------------------------------------------------------------
  338-  348 (18.87/11.69)	EDTIDGSQVAA
  371-  381 (20.81/13.72)	QDTFLGLWIAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12625 with Med33 domain of Kingdom Viridiplantae
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