<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12604

Description U-box domain-containing protein 33 isoform X4
SequenceMIVGTKFNIDQLDVHQVRTYHEKERQDMHKILEKYVLICGRAGVRADKLVVEMDSIEKGIVELVSQRGIGKLVMGAAANKCYSKKMTDLRSKKAIYVRLQAPTFCCIWFVCKGNLVYTRESKSERPNTDSVSPSIPVSPENDTVLRSRSVTEGYNEQVGLRGPFNEYRRVASDNHRIIFSGPTSGGTLRANFPSMSSDRSPSVASRFSSSSYGEMVGDSPTISLARTEGNDTAIDSSTLHHFIPGHHQPSSPSIQAESLNDEPAGSMNDELLDRLEQYVAEAEDARREAFEESIKRRKAEKDAIEARRRAKASETIYADELRQRRDIEEALAKGKEEANQMKSKLNKMLADLQAAQAQTSSLEHQLLNSDTTVQELEQKMFSAVDLLQKYRKERDELQVERDDALNIAEALRKQHSNGSSTTSAFVLFAEFYFHEIEEATRRFDPALKIGEGGYGSIYRGLLRHTHVAIKMLHPHSSQGPSEFQQEVNILSKLRHPNIVTLIGACPEAWALVYEYLPNGSLEDRLTCKDNTPPLSWQTRIRVASELCSALIFLHSCTARGIIHGDLKPANILLDANFVSKLSDFGICRVLSEDEFSEKSTSLCYRTDPKGTFAYLDPEFLDTGELTPKSDVYSFGIILLRLLTGRPALGIKNEVQYALDKGNLKDLLDPTAGDWPFVQAKQLAHLAMNCCEKNGRLRPELSSEVWKVLEPMRASCGASSFRMGSEERCEIPSYFICPIFQETMQDPVVAADGFTYEAEALRGWLDSGHDTSPMTNLALSNTNLVPNHALRSAIQEWLQQH
Length800
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.455
Instability index49.81
Isoelectric point5.89
Molecular weight89614.22
Publications
PubMed=23773524

Function

Annotated function Functions as an E3 ubiquitin ligase. 
ECO:0000256	ARBA:ARBA00003861
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.18|      42|      87|     480|     521|       1
---------------------------------------------------------------------------
  480-  521 (73.75/50.57)	PSEFQQEVNILSKLRHPNIVTLIGA...CPEAWALVYEYLPNGSL
  568-  612 (66.43/44.80)	PANILLDANFVSKLSDFGICRVLSEdefSEKSTSLCYRTDPKGTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.73|      48|      49|     187|     235|       2
---------------------------------------------------------------------------
  133-  177 (52.44/29.05)	......PSIpvSPENDTVL.RSRSVTEGYNEQVGlRGPFNEYRRVASDNHRI
  187-  234 (81.20/56.13)	TLRANFPSM..SSDRSPSV.ASRFSSSSYGEMVG.DSPTISLARTEGNDTAI
  238-  276 (53.09/32.63)	TLHHFIPGH..HQPSSPSIqAESLNDEPAGSM.N.DEL...LDRLE......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.08|      46|      92|     279|     325|       3
---------------------------------------------------------------------------
  279-  319 (52.73/35.60)	...........VAEAEDARREAFEESIKRRKAEKDAIEARRR..AKASETIYAD
  320-  370 (55.89/40.43)	ELRQRrdieeaLAKGKEEANQ.MKSKLNKMLADLQAAQAQTS..SLEHQLLNSD
  375-  424 (49.45/33.21)	ELEQK..mfsaVDLLQKYRKERDELQVERDDALNIA.EALRKqhSNGSSTTSA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.88|      22|      24|      27|      50|       4
---------------------------------------------------------------------------
   27-   50 (33.17/30.73)	DMHKILEKYVLICGRAGVraDKLV
   52-   73 (35.71/25.53)	EMDSIEKGIVELVSQRGI..GKLV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12604 with Med32 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEDARREAFEESIKRRKAEKDAIEARRRAKASETIYAD
2) AIDSSTLHHFIPGHHQPSSPSIQAESLNDEPAGSMNDELLDRLEQY
3) SKSERPNTDSVSPSIPVSPENDTVLRSRSVTE
282
233
121
319
278
152










Molecular Recognition Features






MoRF SequenceStartStop




NANANA