<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12603

Description U-box domain-containing protein 33 isoform X1
SequenceMALESPVPEIRQSPVRYPEVDLSGLNLNEEIESPLTPPARVAVDMIYVAVGKDLKESEPTLKWALHKSGGSRICILHVHTPAQKIPMMGTKFNIDQLDVHQVRTYHEKERQDMHKILEKYVLICGRAGVRADKLVVEMDSIEKGIVELVSQRGIGKLVMGAAANKCYSKKMTDLRSKKAIYVRLQAPTFCCIWFVCKGNLVYTRESKSERPNTDSVSPSIPVSPENDTVLRSRSVTEGYNEQVGLRGPFNEYRRVASDNHRIIFSGPTSGGTLRANFPSMSSDRSPSVASRFSSSSYGEMVGDSPTISLARTEGNDTAIDSSTLHHFIPGHHQPSSPSIQAESLNDEPAGSMNDELLDRLEQYVAEAEDARREAFEESIKRRKAEKDAIEARRRAKASETIYADELRQRRDIEEALAKGKEEANQMKSKLNKMLADLQAAQAQTSSLEHQLLNSDTTVQELEQKMFSAVDLLQKYRKERDELQVERDDALNIAEALRKQHSNGSSTTSAFVLFAEFYFHEIEEATRRFDPALKIGEGGYGSIYRGLLRHTHVAIKMLHPHSSQGPSEFQQEVNILSKLRHPNIVTLIGACPEAWALVYEYLPNGSLEDRLTCKDNTPPLSWQTRIRVASELCSALIFLHSCTARGIIHGDLKPANILLDANFVSKLSDFGICRVLSEDEFSEKSTSLCYRTDPKGTFAYLDPEFLDTGELTPKSDVYSFGIILLRLLTGRPALGIKNEVQYALDKGNLKDLLDPTAGDWPFVQAKQLAHLAMNCCEKNGRLRPELSSEVWKVLEPMRASCGASSFRMGSEERCEIPSYFICPIFQETMQDPVVAADGFTYEAEALRGWLDSGHDTSPMTNLALSNTNLVPNHALRSAIQEWLQQH
Length885
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.438
Instability index52.28
Isoelectric point5.89
Molecular weight98979.97
Publications
PubMed=23773524

Function

Annotated function Functions as an E3 ubiquitin ligase. 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12603
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.18|      42|      87|     565|     606|       1
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  565-  606 (73.75/52.29)	PSEFQQEVNILSKLRHPNIVTLIGA...CPEAWALVYEYLPNGSL
  653-  697 (66.43/46.34)	PANILLDANFVSKLSDFGICRVLSEdefSEKSTSLCYRTDPKGTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.73|      48|      49|     272|     320|       2
---------------------------------------------------------------------------
  218-  262 (52.44/22.89)	......PSIpvSPENDTVL.RSRSVTEGYNEQVGlRGPFNEYRRVASDNHRI
  272-  319 (81.20/44.26)	TLRANFPSM..SSDRSPSV.ASRFSSSSYGEMVG.DSPTISLARTEGNDTAI
  323-  361 (53.09/25.71)	TLHHFIPGH..HQPSSPSIqAESLNDEPAGSM.N.DEL...LDRLE......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.08|      46|      92|     364|     410|       3
---------------------------------------------------------------------------
  364-  404 (52.73/32.36)	...........VAEAEDARREAFEESIKRRKAEKDAIEARRR..AKASETIYAD
  405-  455 (55.89/36.77)	ELRQRrdieeaLAKGKEEANQ.MKSKLNKMLADLQAAQAQTS..SLEHQLLNSD
  460-  509 (49.45/30.17)	ELEQK..mfsaVDLLQKYRKERDELQVERDDALNIA.EALRKqhSNGSSTTSA.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12603 with Med32 domain of Kingdom Viridiplantae
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