<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12597
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MWTNVFKIGGLHQISWFQFLPHESDVSSLVDKSVKLDKKDAATWLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGQHSSVVEKAQSAVSKLRVLASGLWVAPGDSEEVAAALSQALRNCMERKLRGLSYVRYGDVFTRHHPFSQNEELFRKGQPVVEFIFSATEEAIFVHVIISAKHIRALSSGDIDKISEDTSNVSGERLPVIVSPHGMRGRLTGCCPADLVKQVYLSSCKFSASNGIVGLPCNVSRSGYQLKGQNCYVEVSLGCTTPGNNNIKESSRMLIYPPEAILVPVVQTACARSSLKRFWLQNWIGPSLSFTSSFMHCFDFNSDAKVNSTDGSWLDANITRSNRHYNSSSNSNSSSVSSVSTSSSDSDYKISGAGDLEADADSLMCRPSGLSSVDQSQNDNLKAGFKRSRTGISESFSQAGAVINPSTSDYASMEVNNSAITGGNDQTGLQWGWDDDDRGVGMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMFPAADSADVGSSPCPSMMDVQDQMLLPVGFPSFDSFNQPPPPASLDDSLGKQQEVIKSTAVTNQVNNASAAIAGEFDHLIKAEALMTFAPEYGAVETPTGEKPHSIFRNPYLPKSREVDTSNSSSNSYVYSATPPLSPCFDACEEKSGVTVNLKTGAGKRDTSSIIQSKRYYTHIESGKQKNDGKLCGSDHSCATREAQVAQSPFYGFNSTNSVKSIHNKTQKANEVLLKADSFGQSMKTVLATEVECLMCQAFMCKIRHTLLSSSSYLPVGASRMSGSTIINQPQGEAVVTVDNLSSKSEMKKKEIIPVRIAGDIDGGLLDGTLNAPVGVWRSVGVSKGMKQPSSALEACHSVQHNSFIEESMLAYGLRQPLQELLDGMALLVQQATSLVDVALDADNNDGPYGWLALQEQWRRGFSCGPSMVHAGCGGVLASCHSLDIAGVELIDPLSADVQASFTLTLLQNDIKTAMKSAFGTMEGPLSVVDWCKGRSQSNDGGISGDGFSAESTASASECRDSSSTISFSVGEPISPSQSSAGGSSLKDGIRVDEASERRLSQDTCLSESEQLPGSRLRPTLSAVPYPAILVGYQDDWLKTSPSSLQLWEKAPFEPYAMPKHMSYYVVCPDINALTTAATDFFQQLGTVYETCKLGTHSPQCMGNEMEIDSGKNVSSGFVLIDCPQSMKIDSSSTSMLGSISDYFLSLSNGWDLESYLKSLSKVLRNLKLSSCMTMNPKEGSTGPCTVIYVVCPFPEPLAVLQTVVESSIAVGSVVLSSDKERRSTLQNQVGKALSYSAAVDESLSNVLTLSGFCIPKLVLQIVTVDAIFRVTSPALSELLVLKEIAFTVYNKARRISRGSSSDMVQSSSMSGRSHPVLMQMTSPVPGMWKDCVGPRSIGTSLQREAELDASLRSGSWDNWQTSRGGSLGCDPNRIGDFSIQDEVRYLFEPLYILAEPGSLDRGLSFPMSGNLMAESSKLLLDDGTSGNFMQSSASSGGGDTGPNTQSETSEPDGSGSAHQKSLPSLHCCYGWTEDWRWLVCIWTDSRGELLDNYIYPFGGISSRQDTKGLQSLFVQILQQGCQILQACPPESAIAKPRDFVIARIGSFFELECQEWQKALYAIGGSEVKKWSLQLRRSVPDGMSASSNGASLQQQEIGGMGQPSTRKQLIGGQGMVDNSRGLLQWVQSISFVSVSIDHSLQLMFQADIVSHGTSQSSGVVSQPGYLEGYTPVKSLGSTSTSYILIPSPNMRFLPPVGLQLRTCLTAESPPLAHLLHSKGCAIPLSTGFVVSKAVPTMRRDARGISKEEWPSVLSVGLVDYYGGSNIIQEKFLKGVGKVGGRGASSETRDVEVETHLILENIAAELHALSWMTVSPAYLERRSALPFHCDMVLRLRRLLHFADKEVSRQPEKTQV |
Length | 1930 |
Position | Kinase |
Organism | Nicotiana sylvestris (Wood tobacco) (South American tobacco) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae>
Nicotiana.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.216 |
Instability index | 53.05 |
Isoelectric point | 5.42 |
Molecular weight | 208669.81 |
Publications | PubMed=23773524
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP12597
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 561.98| 231| 827| 656| 1037| 1
---------------------------------------------------------------------------
500- 685 (145.74/153.98) .................................................................................................................................FFENDVLPFG..EP.PGTAESQALMFPAA....DSA.DVGSSPCP.SMMDVQDQMllPVGFPSFDSFNQppppASLDDSLGKQQEVikSTAVTNQVNNASAAIAGEFD.HLIKAEALMTFAPEYGAVETP...........tgekphsifrnpylpksrevdtsnsssnsyvysatpPLSPcfdaCEEKSGVTvNLKTGAgKRDTSS
752- 1072 (311.83/285.07) ADSFGQSMKTVLATeveC.LMCQAFMCkirhtlLSSSSYLPVGASRMSGSTIINQPQGeavVTVDNlSSKSEMKKKEIIPVRIAGDIDgglLDGTLNAPVGVWRSVGVSKGMkqpssaleachsvqhnsFIEESMLAYGlrQPlQELLDGMALLVQQAtslvDVAlDADNNDGPyGWLALQEQW..RRGFSCGPSMVH....AGCGGVLASCHSL..DIAGVELIDPLSADVQASFTlTLLQNDIKTAMKSAFGTMEGPlsvvdwckgrsqsndggisgdgfsaestasasecrdssstisfsvgePISP....SQSSAGGS.SLKDGI.RVDEAS
1154- 1249 (104.41/20.63) ATDFFQQLGTVYET...CkLGTHSPQC......MGNEMEIDSGKNVSSGFVLIDCPQS...MKIDS.SSTSMLGSISDYFLSLSNGWD...LESYLKSLSKVLRNLKLSSCM................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 285.16| 86| 122| 1375| 1469| 2
---------------------------------------------------------------------------
1375- 1469 (144.50/98.24) GSSSDMVQSSSMSGRSHpvlmqmtsPVPGMWKDCVGPRSIGTSLQRE.AELDASL.RSGSWD....NWQTSRGGSLGCDPNRIGDFSIQDEVRYLfEPLYI
1500- 1591 (140.66/77.78) GTSGNFMQSSASSGGGD........TGPNTQSETSEPDGSGSAHQKSlPSLHCCYgWTEDWRwlvcIWTDSRGELLDNYIYPFGGISSRQDTKGL.QSLFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.60| 24| 831| 1005| 1037| 3
---------------------------------------------------------------------------
386- 409 (43.20/16.78) SSDSDYKISGAG.DLEADADSLMCR
1012- 1036 (38.40/19.75) SQSNDGGISGDGfSAESTASASECR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 110.62| 33| 976| 300| 333| 5
---------------------------------------------------------------------------
301- 333 (62.23/41.11) PEAILVPVVQTACARSSL.......KRFWLQNWIGPSLSF
1273- 1312 (48.40/25.41) PLAVLQTVVESSIAVGSVvlssdkeRRSTLQNQVGKALSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 125.08| 36| 1108| 620| 655| 6
---------------------------------------------------------------------------
620- 655 (63.42/33.29) TGEKPHSIFRNPYLPKSREVDTSNSSSNSYVYSATP
1729- 1764 (61.66/32.16) TSQSSGVVSQPGYLEGYTPVKSLGSTSTSYILIPSP
---------------------------------------------------------------------------
|