<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12590

Description mediator of RNA polymerase II transcription subunit 15a isoform X1
SequenceMDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKSGTPLLSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSSSVNDSFWQLHCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDEGVDPSAVASATEGGEGITVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1356
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.751
Instability index71.44
Isoelectric point9.38
Molecular weight149044.24
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12590
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.12|      15|      15|     283|     297|       1
---------------------------------------------------------------------------
  283-  297 (31.12/ 8.85)	QSMMQSHMQQQQQQQ
  301-  315 (28.01/ 6.90)	QQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.65|      52|      55|     469|     521|       2
---------------------------------------------------------------------------
  397-  457 (53.66/ 9.65)	QQqliaqqanatnlQQNQLIG.Q.Q..NT.MPDVQQRIVGQQNNYSSLQ...QQQLLNQQNNLQNMHQQ
  461-  519 (85.93/22.75)	SQ......sniagvQQQQLTGSQ.QPGNSgVPSNQHPIHMLQQSKVPLQ...QQMLQGGTTLLPSQGQQ
  520-  574 (51.05/ 8.77)	SQ........sqpaQQQMMSQSQsQPGQL.....QPPLG.LQQQTNQLQremQQRLQTSGPLLQQQNVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.99|      28|      30|     745|     772|       3
---------------------------------------------------------------------------
  244-  273 (32.27/ 6.18)	QQVVSQQQQQQSQTSQQYLYQQQMHhqMMK
  745-  772 (48.67/13.95)	QQNNITNLQHNSLSGVPTISNSQQH..MVN
  858-  878 (33.05/ 6.54)	QQYHQRQMQQQ.......LYNRQQF..MQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.54|      42|      45|     879|     923|       4
---------------------------------------------------------------------------
  328-  380 (43.63/14.70)	QQTmMqpSSMQStslsnlQQnQQSTVQQSTQSVLH.QRSQsVMRQQQAPMLHQQ
  785-  825 (50.78/11.01)	GNS.L..NSLQQ......VA.TGSLQQNPVNSPQQvNISS.LNSQSGTNPV..Q
  879-  909 (41.12/ 6.87)	.....................QQAKQQQTAQLPAH.QMSQ.LHQMNDANDLKMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.24|      34|      38|     985|    1018|       5
---------------------------------------------------------------------------
  950-  984 (31.84/13.02)	...SPQVTQHPSPqidqqnMLASLTK..SG..TP....LLSASSPF
  985- 1018 (56.99/29.53)	VVPSPSTPLAPSP......MPGDSEKVSAG..LA....LHTTAGNI
 1025- 1059 (29.49/11.48)	VASAPAQSLAIG.......TPG....ISASplLAeftsLDGTHANV
 1062- 1095 (42.92/20.29)	AVSGKSSVEQPLE......RLMKVVKNMSP..KA....LNSSVSDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.00|      16|      17|     109|     125|       6
---------------------------------------------------------------------------
  124-  141 (21.92/ 6.40)	GQnaLGPGSHSMQSQVNS
  728-  743 (28.07/ 6.94)	GQ..GNPPMQPVQGSMAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.51|      17|      17|     611|     627|       7
---------------------------------------------------------------------------
  611-  627 (30.13/20.23)	EEVYQKI..KSMREMYLPE
  629-  647 (24.74/15.08)	NDLYQKIaaKVQQHDSLPQ
  651-  664 (16.64/ 7.35)	TEQIEKL..KVFK.MTL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.47|      21|      39|     147|     178|       9
---------------------------------------------------------------------------
  147-  167 (41.18/10.01)	P.VPMVANQTQTRQP.LLQQN..IQ
  183-  207 (25.30/14.42)	PaLPPVSNLTQATMPnVMGQNanLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.82|      18|      21|    1268|    1285|      12
---------------------------------------------------------------------------
 1268- 1285 (33.59/26.55)	VPANYPNCSPVLLDKFPV
 1287- 1304 (29.23/22.03)	VSKEYEDLSMKAKSRFSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.43|      13|      21|      72|      88|      13
---------------------------------------------------------------------------
   72-   88 (15.33/23.00)	LKKIAVrfeeKIYTAAT
   94-  106 (22.09/16.35)	LRKISL....KMLTMET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      19|      23|     670|     688|      15
---------------------------------------------------------------------------
  670-  688 (33.19/21.14)	FLRLNK.HDIQPSHKEKLLQ
  696-  715 (30.88/18.98)	FLNSNRpRKPTPPLQGQLPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12590 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQ
2) LSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
3) MDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDS
4) SFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKS
5) SLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEV
6) TSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQ
97
978
1
694
438
257
252
1013
45
973
613
404










Molecular Recognition Features






MoRF SequenceStartStop




NANANA