<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12586

Description mediator of RNA polymerase II transcription subunit 15a isoform X4
SequenceMDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKSGTPLLSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSSSVNDSFWQLHCSEASELESTATSSVKRPRLEKNKNTN
Length1197
PositionTail
OrganismNicotiana sylvestris (Wood tobacco) (South American tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.02
Grand average of hydropathy-0.852
Instability index73.46
Isoelectric point9.79
Molecular weight131944.05
Publications
PubMed=23773524

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12586
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     256.65|      53|      55|     469|     521|       2
---------------------------------------------------------------------------
  309-  350 (55.67/ 9.23)	QQ............QQQQQQNLL.QP..TQIQSSQQT..MMQPSS..........MQS..TSLSNlqQNQQ
  397-  457 (55.75/ 9.26)	QQqliaqqanatnlQQNQLIG.Q.Q..NT.MPDVQQRIVGQQNNYSSLQ...QQQLLNQQNNLQN..MHQQ
  461-  519 (93.28/21.42)	SQ......sniagvQQQQLTGSQ.QPGNSGVPSNQHPIHMLQQSKVPLQ...QQMLQGGTTLLPS..QGQQ
  520-  574 (51.95/ 8.03)	SQ........sqpaQQQMMSQSQsQPGQL.....QPPLG.LQQQTNQLQremQQRLQTSGPLLQQ..QNVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.28|      21|      30|     745|     772|       3
---------------------------------------------------------------------------
  745-  772 (29.20/13.45)	QQNNITNLQHNslsgvptISNSQQHMVN
  858-  878 (33.08/ 6.37)	QQYHQRQMQQQ.......LYNRQQFMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     265.96|      52|      54|     956|    1007|       4
---------------------------------------------------------------------------
  774-  836 (56.98/15.87)	VQS....GSTVD..LGQ.........GNSLNSL.QQV...ATGSLQQ.NPVN.SPqqvniSSLNSQSG.TnpvqanlgSLQPNS.N
  919-  952 (43.26/10.03)	..............LQQ.........QQSVGQR.VGS...HHPQLK........P.....GISSPQIH.Q........AL...SPQ
  953- 1004 (86.36/28.37)	VTQ....HPSPQ..IDQ.........QNMLASL.TKS...GTPLLSASSPFV.VP.....SPSTPLAP.S........PMPGDSEK
 1005- 1058 (40.57/ 8.88)	VSAglalHTTAGniMHQ.........QATVASApAQSlaiGTPGISA.............SPL..LAEfT........SLDGTHAN
 1059- 1115 (38.79/ 8.13)	VSAavsgKSS....VEQplerlmkvvKNM.......S...PKALNSSVSDISsVV.....SMIDRIAG.S.........APGNGSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     276.13|      51|      55|     109|     159|       5
---------------------------------------------------------------------------
   14-   57 (54.49/17.93)	QAQGGGEG.AA......A...AGPPTGAMD..SG.DWRT..QL.....LP.....DS....RQ.......rivNKIMETL
   58-  116 (45.36/13.42)	KRHLPVSG.QE......GvqeLKKIAVRFE..EKIYTAAtsQQdylrkISLKMLTMET.K........sQ...NPINNSM
  117-  170 (86.30/33.64)	QPNAASSG.QN......A...LGPGSHSMQ..SQVNSQA..QQ.....LPVPMVANQT.QTRQ...pllQ...QNIQNNM
  171-  224 (35.72/ 8.66)	....ASTGlQNsasltpA...LPPVSNLTQ..AT..............MPNVMGQNANlQTMQnmqnvgQ...NSVGNAI
  225-  271 (54.26/17.82)	GQGMPS....N......M...VANSQRQMQgrQQVVSQQ..QQ............QQS.QTSQ..qylyQ...QQMHHQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.35|      17|      22|     697|     718|       6
---------------------------------------------------------------------------
  697-  718 (25.94/19.14)	LnsNRPR....KPTPPLQgqlP.QPSM
  720-  741 (26.41/ 7.51)	L..QQPQsldgQGNPPMQ...PvQGSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     180.19|      48|     496|     360|     410|       7
---------------------------------------------------------------------------
  360-  410 (79.11/27.27)	VLHQRSQSVMRQQQAPM...LHQ..........................QQSAMLQQ.PILPAQQHQqqQLiAQQANATNL
  613-  650 (39.18/ 8.14)	V.YQKIKS.MREMYLPElndLYQ..........................KIAAKVQQhDSLP.QRPQ..............
  837-  906 (61.90/17.76)	VLQQ...SLPKQHEQQM...L.QnqqlrqqyhqrqmqqqlynrqqfmqqQQAKQQQT.AQLPAHQMS..QL.HQMNDANDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12586 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQ
2) LSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
3) MDGNNWRAAQAQAQAQGGGEGAAAAGPPTGAMDSGDWRTQLLPDS
4) SFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKS
5) SLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEV
6) TSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQ
97
978
1
694
438
257
252
1013
45
973
613
404










Molecular Recognition Features






MoRF SequenceStartStop




NANANA